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    Brd8 bromodomain containing 8 [ Mus musculus (house mouse) ]

    Gene ID: 78656, updated on 23-Jun-2021

    Summary

    Official Symbol
    Brd8provided by MGI
    Official Full Name
    bromodomain containing 8provided by MGI
    Primary source
    MGI:MGI:1925906
    See related
    Ensembl:ENSMUSG00000003778
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    S; p12; SMAP; 2610007E11Rik; 4432404P07Rik
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 21.2), CNS E14 (RPKM 15.8) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Brd8 in Genome Data Viewer
    Location:
    18; 18 B1
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (34731668..34757916, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (34598611..34624863, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 18 NC_000084.5 (34758269..34784464, complement)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene NME/NM23 family member 5 Neighboring gene BRD8 domain containing Neighboring gene predicted gene, 41688 Neighboring gene kinesin family member 20A Neighboring gene CDC23 cell division cycle 23 Neighboring gene nuclear encoded rRNA 5S 25 Neighboring gene glial cell line derived neurotrophic factor family receptor alpha 3 Neighboring gene predicted gene, 52376

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables nuclear receptor coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables thyroid hormone receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in cellular response to thyroid hormone stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within chromatin organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in histone H2A acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in histone H4 acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in histone acetylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of growth IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of NuA4 histone acetyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of NuA4 histone acetyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of Swr1 complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    bromodomain-containing protein 8

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289606.1NP_001276535.1  bromodomain-containing protein 8 isoform 2

      See identical proteins and their annotated locations for NP_001276535.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the coding region, compared to variant 1. This results in a shorter isoform (2), compared to isoform 1.
      Source sequence(s)
      AK032320, AK161689, AV322131, CD555707
      Consensus CDS
      CCDS70879.1
      UniProtKB/Swiss-Prot
      Q8R3B7
      Related
      ENSMUSP00000095229.4, ENSMUST00000097626.10
      Conserved Domains (1) summary
      cd05507
      Location:709812
      Bromo_brd8_like; Bromodomain, brd8_like subgroup. In mammals, brd8 (bromodomain containing 8) interacts with the thyroid hormone receptor in a ligand-dependent fashion and enhances thyroid hormone-dependent activation from thyroid response elements. Brd8 is thought to be ...
    2. NM_001289607.1NP_001276536.1  bromodomain-containing protein 8 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon in the coding region, compared to variant 1. This results in a shorter isoform (3), compared to isoform 1.
      Source sequence(s)
      AK032320, AK161689, AV322131, CD555707
      Consensus CDS
      CCDS70880.1
      UniProtKB/Swiss-Prot
      Q8R3B7
      UniProtKB/TrEMBL
      D3YZC7
      Related
      ENSMUSP00000111432.2, ENSMUST00000115766.8
      Conserved Domains (1) summary
      cd05507
      Location:712815
      Bromo_brd8_like; Bromodomain, brd8_like subgroup. In mammals, brd8 (bromodomain containing 8) interacts with the thyroid hormone receptor in a ligand-dependent fashion and enhances thyroid hormone-dependent activation from thyroid response elements. Brd8 is thought to be ...
    3. NM_001361136.1NP_001348065.1  bromodomain-containing protein 8 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an exon and its 3' terminal exon extends past a splice site that is used in variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 4 which is longer and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC074335
      Consensus CDS
      CCDS89217.1
      Related
      ENSMUSP00000111431.2, ENSMUST00000115765.2
      Conserved Domains (2) summary
      cd05507
      Location:782885
      Bromo_brd8_like; Bromodomain, brd8_like subgroup. In mammals, brd8 (bromodomain containing 8) interacts with the thyroid hormone receptor in a ligand-dependent fashion and enhances thyroid hormone-dependent activation from thyroid response elements. Brd8 is thought to be ...
      cl26464
      Location:176356
      Atrophin-1; Atrophin-1 family
    4. NM_030147.3NP_084423.2  bromodomain-containing protein 8 isoform 1

      See identical proteins and their annotated locations for NP_084423.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript.
      Source sequence(s)
      AK032320, AK161689, AV322131, CD555707
      Consensus CDS
      CCDS50248.1
      UniProtKB/Swiss-Prot
      Q8R3B7
      Related
      ENSMUSP00000003876.4, ENSMUST00000003876.10
      Conserved Domains (1) summary
      cd05507
      Location:782885
      Bromo_brd8_like; Bromodomain, brd8_like subgroup. In mammals, brd8 (bromodomain containing 8) interacts with the thyroid hormone receptor in a ligand-dependent fashion and enhances thyroid hormone-dependent activation from thyroid response elements. Brd8 is thought to be ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      34731668..34757916 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006526358.5XP_006526421.1  bromodomain-containing protein 8 isoform X1

      Conserved Domains (2) summary
      cd05507
      Location:712815
      Bromo_brd8_like; Bromodomain, brd8_like subgroup. In mammals, brd8 (bromodomain containing 8) interacts with the thyroid hormone receptor in a ligand-dependent fashion and enhances thyroid hormone-dependent activation from thyroid response elements. Brd8 is thought to be ...
      pfam08493
      Location:199415
      AflR; Aflatoxin regulatory protein
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