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    Acap2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 [ Mus musculus (house mouse) ]

    Gene ID: 78618, updated on 26-Sep-2022

    Summary

    Official Symbol
    Acap2provided by MGI
    Official Full Name
    ArfGAP with coiled-coil, ankyrin repeat and PH domains 2provided by MGI
    Primary source
    MGI:MGI:1925868
    See related
    Ensembl:ENSMUSG00000049076 AllianceGenome:MGI:1925868
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CNT-B2; Centb2; mKIAA0041; 4832442G16; 9530039J15Rik
    Summary
    Enables phosphatidylinositol-3,5-bisphosphate binding activity and small GTPase binding activity. Predicted to be involved in cellular response to nerve growth factor stimulus and endocytic recycling. Predicted to act upstream of or within actin filament-based process. Predicted to be located in ruffle. Predicted to be active in endosome membrane. Is expressed in several structures, including adipose tissue; brain; genitourinary system; liver; and spleen. Orthologous to human ACAP2 (ArfGAP with coiled-coil, ankyrin repeat and PH domains 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in bladder adult (RPKM 7.0), frontal lobe adult (RPKM 5.5) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Acap2 in Genome Data Viewer
    Location:
    16; 16 B2
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (30911230..31020105, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (31092412..31201285, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene xyloside xylosyltransferase 1 Neighboring gene predicted gene, 41440 Neighboring gene predicted gene, 46554 Neighboring gene zinc finger protein 161 pseudogene Neighboring gene predicted gene, 52237 Neighboring gene predicted gene, 41442 Neighboring gene protein phosphatase 1, regulatory inhibitor subunit 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatidylinositol-3,5-bisphosphate binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables small GTPase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within actin filament-based process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to nerve growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endocytic recycling ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in endosome membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in ruffle ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2
    Names
    centaurin, beta 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_030138.2NP_084414.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2

      See identical proteins and their annotated locations for NP_084414.1

      Status: VALIDATED

      Source sequence(s)
      AC090430, AK129041, BB465902, BY014253
      Consensus CDS
      CCDS49823.1
      UniProtKB/Swiss-Prot
      Q6ZQK5, Q9CTS8
      Related
      ENSMUSP00000154983.2, ENSMUST00000230614.2
      Conserved Domains (7) summary
      cd07638
      Location:18217
      BAR_ACAP2; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with Coiled-coil, ANK repeat and PH domain containing protein 2
      smart00105
      Location:402518
      ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
      cd00204
      Location:602718
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13250
      Location:269365
      PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
      pfam00169
      Location:267361
      PH; PH domain
      pfam12796
      Location:602696
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:630663
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      30911230..31020105 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006522747.5XP_006522810.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X4

      UniProtKB/TrEMBL
      A0A338P6P6
      Related
      ENSMUSP00000156077.2, ENSMUST00000229010.3
      Conserved Domains (7) summary
      PTZ00322
      Location:669753
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      cd07638
      Location:18217
      BAR_ACAP2; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with Coiled-coil, ANK repeat and PH domain containing protein 2
      COG5347
      Location:387624
      COG5347; GTPase-activating protein that regulates ARFs (ADP-ribosylation factors), involved in ARF-mediated vesicular transport [Intracellular trafficking and secretion]
      cd13250
      Location:269365
      PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
      sd00045
      Location:665698
      ANK; ANK repeat [structural motif]
      cd08851
      Location:399513
      ArfGap_ACAP2; ArfGAP domain of ACAP2 (ArfGAP with Coiled-coil, ANK repeat and PH domains 2)
      pfam13637
      Location:637688
      Ank_4; Ankyrin repeats (many copies)
    2. XM_006522746.5XP_006522809.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X3

      Conserved Domains (7) summary
      PTZ00322
      Location:673757
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      cd07638
      Location:18217
      BAR_ACAP2; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with Coiled-coil, ANK repeat and PH domain containing protein 2
      COG5347
      Location:391628
      COG5347; GTPase-activating protein that regulates ARFs (ADP-ribosylation factors), involved in ARF-mediated vesicular transport [Intracellular trafficking and secretion]
      cd13250
      Location:273369
      PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
      sd00045
      Location:669702
      ANK; ANK repeat [structural motif]
      cd08851
      Location:403517
      ArfGap_ACAP2; ArfGAP domain of ACAP2 (ArfGAP with Coiled-coil, ANK repeat and PH domains 2)
      pfam13637
      Location:641692
      Ank_4; Ankyrin repeats (many copies)
    3. XM_006522743.5XP_006522806.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X1

      Conserved Domains (7) summary
      PTZ00322
      Location:680764
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      cd07638
      Location:18217
      BAR_ACAP2; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with Coiled-coil, ANK repeat and PH domain containing protein 2
      COG5347
      Location:398635
      COG5347; GTPase-activating protein that regulates ARFs (ADP-ribosylation factors), involved in ARF-mediated vesicular transport [Intracellular trafficking and secretion]
      cd13250
      Location:273376
      PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
      sd00045
      Location:676709
      ANK; ANK repeat [structural motif]
      cd08851
      Location:410524
      ArfGap_ACAP2; ArfGAP domain of ACAP2 (ArfGAP with Coiled-coil, ANK repeat and PH domains 2)
      pfam13637
      Location:648699
      Ank_4; Ankyrin repeats (many copies)
    4. XM_006522749.5XP_006522812.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X6

      See identical proteins and their annotated locations for XP_006522812.1

      UniProtKB/TrEMBL
      D4AFX6
      Related
      ENSMUSP00000154852.2, ENSMUST00000231125.2
      Conserved Domains (6) summary
      PTZ00322
      Location:641725
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      cd07638
      Location:18217
      BAR_ACAP2; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with Coiled-coil, ANK repeat and PH domain containing protein 2
      cd13250
      Location:269372
      PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
      sd00045
      Location:637670
      ANK; ANK repeat [structural motif]
      cd08851
      Location:406520
      ArfGap_ACAP2; ArfGAP domain of ACAP2 (ArfGAP with Coiled-coil, ANK repeat and PH domains 2)
      pfam13637
      Location:609660
      Ank_4; Ankyrin repeats (many copies)
    5. XM_006522744.5XP_006522807.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X2

      Conserved Domains (7) summary
      PTZ00322
      Location:676760
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      cd07638
      Location:18217
      BAR_ACAP2; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with Coiled-coil, ANK repeat and PH domain containing protein 2
      COG5347
      Location:394631
      COG5347; GTPase-activating protein that regulates ARFs (ADP-ribosylation factors), involved in ARF-mediated vesicular transport [Intracellular trafficking and secretion]
      cd13250
      Location:269372
      PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
      sd00045
      Location:672705
      ANK; ANK repeat [structural motif]
      cd08851
      Location:406520
      ArfGap_ACAP2; ArfGAP domain of ACAP2 (ArfGAP with Coiled-coil, ANK repeat and PH domains 2)
      pfam13637
      Location:644695
      Ank_4; Ankyrin repeats (many copies)
    6. XM_006522748.5XP_006522811.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X5

      Conserved Domains (6) summary
      PTZ00322
      Location:645729
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      cd07638
      Location:18217
      BAR_ACAP2; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with Coiled-coil, ANK repeat and PH domain containing protein 2
      cd13250
      Location:273376
      PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
      sd00045
      Location:641674
      ANK; ANK repeat [structural motif]
      cd08851
      Location:410524
      ArfGap_ACAP2; ArfGAP domain of ACAP2 (ArfGAP with Coiled-coil, ANK repeat and PH domains 2)
      pfam13637
      Location:613664
      Ank_4; Ankyrin repeats (many copies)
    7. XM_017317162.2XP_017172651.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X7

      Conserved Domains (6) summary
      PTZ00322
      Location:638722
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      cd07638
      Location:18217
      BAR_ACAP2; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with Coiled-coil, ANK repeat and PH domain containing protein 2
      cd13250
      Location:273369
      PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
      sd00045
      Location:634667
      ANK; ANK repeat [structural motif]
      cd08851
      Location:403517
      ArfGap_ACAP2; ArfGAP domain of ACAP2 (ArfGAP with Coiled-coil, ANK repeat and PH domains 2)
      pfam13637
      Location:606657
      Ank_4; Ankyrin repeats (many copies)
    8. XM_017317163.3XP_017172652.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X8

      Conserved Domains (7) summary
      PTZ00322
      Location:489573
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      COG5347
      Location:207444
      COG5347; GTPase-activating protein that regulates ARFs (ADP-ribosylation factors), involved in ARF-mediated vesicular transport [Intracellular trafficking and secretion]
      cd13250
      Location:82185
      PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
      sd00045
      Location:485518
      ANK; ANK repeat [structural motif]
      cd08851
      Location:219333
      ArfGap_ACAP2; ArfGAP domain of ACAP2 (ArfGAP with Coiled-coil, ANK repeat and PH domains 2)
      pfam13637
      Location:457508
      Ank_4; Ankyrin repeats (many copies)
      cl12013
      Location:147
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    9. XM_036160182.1XP_036016075.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X8

      Conserved Domains (7) summary
      PTZ00322
      Location:489573
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      COG5347
      Location:207444
      COG5347; GTPase-activating protein that regulates ARFs (ADP-ribosylation factors), involved in ARF-mediated vesicular transport [Intracellular trafficking and secretion]
      cd13250
      Location:82185
      PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
      sd00045
      Location:485518
      ANK; ANK repeat [structural motif]
      cd08851
      Location:219333
      ArfGap_ACAP2; ArfGAP domain of ACAP2 (ArfGAP with Coiled-coil, ANK repeat and PH domains 2)
      pfam13637
      Location:457508
      Ank_4; Ankyrin repeats (many copies)
      cl12013
      Location:147
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    10. XM_017317164.3XP_017172653.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X9

      Conserved Domains (6) summary
      PTZ00322
      Location:443527
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      cd13250
      Location:78174
      PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
      sd00045
      Location:439472
      ANK; ANK repeat [structural motif]
      cd08851
      Location:208322
      ArfGap_ACAP2; ArfGAP domain of ACAP2 (ArfGAP with Coiled-coil, ANK repeat and PH domains 2)
      pfam13637
      Location:411462
      Ank_4; Ankyrin repeats (many copies)
      cl12013
      Location:147
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    RNA

    1. XR_384614.5 RNA Sequence

    2. XR_384613.5 RNA Sequence