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    Uvrag UV radiation resistance associated gene [ Mus musculus (house mouse) ]

    Gene ID: 78610, updated on 4-Nov-2018

    Summary

    Official Symbol
    Uvragprovided by MGI
    Official Full Name
    UV radiation resistance associated geneprovided by MGI
    Primary source
    MGI:MGI:1925860
    See related
    Ensembl:ENSMUSG00000035354 Vega:OTTMUSG00000058912
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Uvrag1; Uvragl; AI648770; BB124205; 9530039D02Rik
    Expression
    Ubiquitous expression in spleen adult (RPKM 13.8), thymus adult (RPKM 12.8) and 28 other tissues See more
    Orthologs

    Genomic context

    See Uvrag in Genome Data Viewer
    Location:
    7; 7 E1
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (98886742..99141168, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (106035253..106289654, complement)

    Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 33770 Neighboring gene wingless-type MMTV integration site family, member 11 Neighboring gene predicted gene, 33827 Neighboring gene predicted gene 8149 Neighboring gene predicted gene, 39055 Neighboring gene predicted gene, 33882 Neighboring gene diacylglycerol O-acyltransferase 2 Neighboring gene monoacylglycerol O-acyltransferase 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    • Autophagy - animal, organism-specific biosystem (from KEGG)
      Autophagy - animal, organism-specific biosystemAutophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily cons...
    • Autophagy - animal, conserved biosystem (from KEGG)
      Autophagy - animal, conserved biosystemAutophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily cons...
    • Cellular responses to stress, organism-specific biosystem (from REACTOME)
      Cellular responses to stress, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Macroautophagy, organism-specific biosystem (from REACTOME)
      Macroautophagy, organism-specific biosystemcomputationally inferred pathway (not manually curated)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    SH3 domain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    SNARE binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    SNARE binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    DNA repair IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    DNA repair ISO
    Inferred from Sequence Orthology
    more info
     
    SNARE complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    SNARE complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    autophagy ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to DNA damage stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    centrosome cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    centrosome cycle ISO
    Inferred from Sequence Orthology
    more info
     
    chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    double-strand break repair via classical nonhomologous end joining ISO
    Inferred from Sequence Orthology
    more info
     
    maintenance of Golgi location ISO
    Inferred from Sequence Orthology
    more info
     
    receptor catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cytokinesis ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    retrograde vesicle-mediated transport, Golgi to ER ISO
    Inferred from Sequence Orthology
    more info
     
    spindle organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    viral entry into host cell IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    colocalizes_with DNA-dependent protein kinase complex ISO
    Inferred from Sequence Orthology
    more info
     
    centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
     
    early endosome ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    endosome IEA
    Inferred from Electronic Annotation
    more info
     
    late endosome ISO
    Inferred from Sequence Orthology
    more info
     
    lysosome ISO
    Inferred from Sequence Orthology
    more info
     
    midbody ISO
    Inferred from Sequence Orthology
    more info
     
    phagocytic vesicle IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    UV radiation resistance associated protein
    Names
    UV radiation resistance-associated gene protein

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_178635.3NP_848750.3  UV radiation resistance associated protein

      See identical proteins and their annotated locations for NP_848750.3

      Status: VALIDATED

      Source sequence(s)
      AK030814, AK078085, BB530952, BY024873
      Consensus CDS
      CCDS21476.1
      UniProtKB/Swiss-Prot
      Q8K245
      Related
      ENSMUSP00000045297.8, OTTMUSP00000075350, ENSMUST00000037968.9, OTTMUST00000144576
      Conserved Domains (2) summary
      cd00030
      Location:44118
      C2; C2 domain
      pfam10186
      Location:199394
      Atg14; Vacuolar sorting 38 and autophagy-related subunit 14

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000073.6 Reference GRCm38.p4 C57BL/6J

      Range
      98886742..99141168 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006508349.2XP_006508412.1  UV radiation resistance associated protein isoform X1

      Conserved Domains (2) summary
      pfam10186
      Location:156351
      Atg14; Vacuolar sorting 38 and autophagy-related subunit 14
      cl23720
      Location:169260
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
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