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    Asb8 ankyrin repeat and SOCS box-containing 8 [ Mus musculus (house mouse) ]

    Gene ID: 78541, updated on 31-Jan-2019

    Summary

    Official Symbol
    Asb8provided by MGI
    Official Full Name
    ankyrin repeat and SOCS box-containing 8provided by MGI
    Primary source
    MGI:MGI:1925791
    See related
    Ensembl:ENSMUSG00000048175
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AI788835; 4930539L19Rik; C430011H06Rik
    Expression
    Ubiquitous expression in testis adult (RPKM 37.0), heart adult (RPKM 27.0) and 28 other tissues See more
    Orthologs

    Genomic context

    See Asb8 in Genome Data Viewer
    Location:
    15; 15 F1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 15 NC_000081.6 (98134637..98165601, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (97965071..97996009, complement)

    Chromosome 15 - NC_000081.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 41395 Neighboring gene SUMO1/sentrin specific peptidase 1 Neighboring gene predicted gene, 26513 Neighboring gene phosphofructokinase, muscle Neighboring gene coiled-coil domain containing 184 Neighboring gene predicted gene, 33909 Neighboring gene olfactory receptor 288

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    biological_process ND
    No biological Data available
    more info
     
    intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    ankyrin repeat and SOCS box protein 8
    Names
    ASB-8
    ankyrin repeat and SOCS box-containing protein 8

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001170710.1NP_001164181.1  ankyrin repeat and SOCS box protein 8

      See identical proteins and their annotated locations for NP_001164181.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1-3 encode the same protein.
      Source sequence(s)
      AK016001, AK030168, AK087299, BY240190
      Consensus CDS
      CCDS27787.1
      UniProtKB/Swiss-Prot
      Q91ZT9
      UniProtKB/TrEMBL
      A0A0R4J1W1, Q8CDF0, Q9D4Y2
      Related
      ENSMUSP00000121383.1, ENSMUST00000123626.7
      Conserved Domains (4) summary
      PHA02884
      Location:1280
      PHA02884; ankyrin repeat protein; Provisional
      cd00204
      Location:56171
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd03727
      Location:245287
      SOCS_ASB8; SOCS (suppressors of cytokine signaling) box of ASB8-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB8 is highly transcribed in skeletal muscle and in lung carcinoma cell lines. The ...
      sd00045
      Location:5683
      ANK; ANK repeat [structural motif]
    2. NM_001170711.1NP_001164182.1  ankyrin repeat and SOCS box protein 8

      See identical proteins and their annotated locations for NP_001164182.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1-3 encode the same protein.
      Source sequence(s)
      AK016001, AK030168
      Consensus CDS
      CCDS27787.1
      UniProtKB/Swiss-Prot
      Q91ZT9
      UniProtKB/TrEMBL
      A0A0R4J1W1, Q8CDF0, Q9D4Y2
      Related
      ENSMUSP00000115813.1, ENSMUST00000143400.7
      Conserved Domains (4) summary
      PHA02884
      Location:1280
      PHA02884; ankyrin repeat protein; Provisional
      cd00204
      Location:56171
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd03727
      Location:245287
      SOCS_ASB8; SOCS (suppressors of cytokine signaling) box of ASB8-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB8 is highly transcribed in skeletal muscle and in lung carcinoma cell lines. The ...
      sd00045
      Location:5683
      ANK; ANK repeat [structural motif]
    3. NM_030121.4NP_084397.3  ankyrin repeat and SOCS box protein 8

      See identical proteins and their annotated locations for NP_084397.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shortest transcript. Variants 1-3 encode the same protein.
      Source sequence(s)
      AK016001, AK030168, BY240190
      Consensus CDS
      CCDS27787.1
      UniProtKB/Swiss-Prot
      Q91ZT9
      UniProtKB/TrEMBL
      A0A0R4J1W1, Q8CDF0, Q9D4Y2
      Related
      ENSMUSP00000057864.5, ENSMUST00000059112.11
      Conserved Domains (4) summary
      PHA02884
      Location:1280
      PHA02884; ankyrin repeat protein; Provisional
      cd00204
      Location:56171
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd03727
      Location:245287
      SOCS_ASB8; SOCS (suppressors of cytokine signaling) box of ASB8-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB8 is highly transcribed in skeletal muscle and in lung carcinoma cell lines. The ...
      sd00045
      Location:5683
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000081.6 Reference GRCm38.p4 C57BL/6J

      Range
      98134637..98165601 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011245775.2XP_011244077.1  ankyrin repeat and SOCS box protein 8 isoform X1

      See identical proteins and their annotated locations for XP_011244077.1

      UniProtKB/Swiss-Prot
      Q91ZT9
      UniProtKB/TrEMBL
      A0A0R4J1W1
      Related
      ENSMUSP00000119481.1, ENSMUST00000123922.1
      Conserved Domains (4) summary
      PHA02884
      Location:1280
      PHA02884; ankyrin repeat protein; Provisional
      cd00204
      Location:56171
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd03727
      Location:245287
      SOCS_ASB8; SOCS (suppressors of cytokine signaling) box of ASB8-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB8 is highly transcribed in skeletal muscle and in lung carcinoma cell lines. The ...
      sd00045
      Location:5683
      ANK; ANK repeat [structural motif]
    2. XM_006521542.3XP_006521605.1  ankyrin repeat and SOCS box protein 8 isoform X1

      See identical proteins and their annotated locations for XP_006521605.1

      UniProtKB/Swiss-Prot
      Q91ZT9
      UniProtKB/TrEMBL
      A0A0R4J1W1
      Conserved Domains (4) summary
      PHA02884
      Location:1280
      PHA02884; ankyrin repeat protein; Provisional
      cd00204
      Location:56171
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd03727
      Location:245287
      SOCS_ASB8; SOCS (suppressors of cytokine signaling) box of ASB8-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB8 is highly transcribed in skeletal muscle and in lung carcinoma cell lines. The ...
      sd00045
      Location:5683
      ANK; ANK repeat [structural motif]
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