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    Arhgap10 Rho GTPase activating protein 10 [ Mus musculus (house mouse) ]

    Gene ID: 78514, updated on 19-Mar-2019

    Summary

    Official Symbol
    Arhgap10provided by MGI
    Official Full Name
    Rho GTPase activating protein 10provided by MGI
    Primary source
    MGI:MGI:1925764
    See related
    Ensembl:ENSMUSG00000037148
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PSGAP; PS-GAP; PSGAP-m; PSGAP-s; A930033B01Rik
    Expression
    Ubiquitous expression in placenta adult (RPKM 13.3), bladder adult (RPKM 9.9) and 27 other tissues See more
    Orthologs

    Genomic context

    See Arhgap10 in Genome Data Viewer
    Location:
    8; 8 C1
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 8 NC_000074.6 (77250366..77517953, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (79774265..80041806, complement)

    Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene predicted gene 10649 Neighboring gene ribosomal protein L7A pseudogene Neighboring gene nuclear receptor subfamily 3, group C, member 2 Neighboring gene RIKEN cDNA 0610038B21 gene Neighboring gene protein arginine methyltransferase 9 Neighboring gene transmembrane protein 184C

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Chemically induced (ENU) (1) 
    • Endonuclease-mediated (1) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    GTPase activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytosol IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    rho GTPase-activating protein 10
    Names
    PH and SH3 domain-containing rhoGAP protein
    rho-type GTPase-activating protein 10

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001363417.1NP_001350346.1  rho GTPase-activating protein 10 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC109139, AC119248
      Conserved Domains (5) summary
      cd12065
      Location:710763
      SH3_GRAF2; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase 2
      cd01249
      Location:267372
      BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
      cl02570
      Location:367547
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
      cl12013
      Location:19225
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
      cl25496
      Location:553699
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    2. NM_001363418.1NP_001350347.1  rho GTPase-activating protein 10 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC109139, AC119248
      Conserved Domains (4) summary
      cd12065
      Location:681734
      SH3_GRAF2; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase 2
      cd04374
      Location:367569
      RhoGAP_Graf; RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences ...
      cd01249
      Location:267372
      BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
      cl12013
      Location:19225
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    3. NM_001363419.1NP_001350348.1  rho GTPase-activating protein 10 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC109139, AC119248
      Conserved Domains (5) summary
      cd12065
      Location:629682
      SH3_GRAF2; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase 2
      cd04374
      Location:264466
      RhoGAP_Graf; RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences ...
      cd01249
      Location:164269
      BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
      cl12013
      Location:1122
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
      cl25496
      Location:472618
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    4. NM_001363420.1NP_001350349.1  rho GTPase-activating protein 10 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC109139, AC119248
      Conserved Domains (5) summary
      cd12065
      Location:607660
      SH3_GRAF2; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase 2
      cd01249
      Location:164269
      BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
      cl02570
      Location:264444
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
      cl12013
      Location:1122
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
      cl25496
      Location:450596
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    5. NM_001363421.1NP_001350350.1  rho GTPase-activating protein 10 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC109139, AC119248
      Conserved Domains (4) summary
      cd12065
      Location:578631
      SH3_GRAF2; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase 2
      cd04374
      Location:264466
      RhoGAP_Graf; RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences ...
      cd01249
      Location:164269
      BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
      cl12013
      Location:1122
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    6. NM_030113.2NP_084389.2  rho GTPase-activating protein 10 isoform 1

      See identical proteins and their annotated locations for NP_084389.2

      Status: VALIDATED

      Source sequence(s)
      AC109139, AC119248, AK041867, BI736055, BU151977, CF106470, CN703944, CV783737
      Consensus CDS
      CCDS22425.1
      UniProtKB/Swiss-Prot
      Q6Y5D8
      UniProtKB/TrEMBL
      Q8C9L7
      Related
      ENSMUSP00000075658.4, ENSMUST00000076316.5
      Conserved Domains (5) summary
      cd12065
      Location:732785
      SH3_GRAF2; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase 2
      cd04374
      Location:367569
      RhoGAP_Graf; RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences ...
      cd01249
      Location:267372
      BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
      pfam00169
      Location:269367
      PH; PH domain
      cl12013
      Location:19225
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    RNA

    1. NR_156496.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC109139, AC119248

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000074.6 Reference GRCm38.p4 C57BL/6J

      Range
      77250366..77517953 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017313016.1XP_017168505.1  rho GTPase-activating protein 10 isoform X4

    2. XM_017313020.1XP_017168509.1  rho GTPase-activating protein 10 isoform X10

    3. XM_017313017.1XP_017168506.1  rho GTPase-activating protein 10 isoform X7

      UniProtKB/Swiss-Prot
      Q6Y5D8
      Conserved Domains (5) summary
      cd12065
      Location:629682
      SH3_GRAF2; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase 2
      cd04374
      Location:264466
      RhoGAP_Graf; RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences ...
      cd01249
      Location:164269
      BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
      cl12013
      Location:1122
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
      cl25496
      Location:472618
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    4. XM_017313015.1XP_017168504.1  rho GTPase-activating protein 10 isoform X3

    5. XM_011248553.2XP_011246855.1  rho GTPase-activating protein 10 isoform X5

      Conserved Domains (5) summary
      cd12065
      Location:688741
      SH3_GRAF2; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase 2
      cd04374
      Location:323525
      RhoGAP_Graf; RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences ...
      cd01249
      Location:223328
      BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
      pfam00169
      Location:225323
      PH; PH domain
      cl12013
      Location:9181
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    6. XM_006531500.2XP_006531563.1  rho GTPase-activating protein 10 isoform X7

      UniProtKB/Swiss-Prot
      Q6Y5D8
      Conserved Domains (5) summary
      cd12065
      Location:629682
      SH3_GRAF2; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase 2
      cd04374
      Location:264466
      RhoGAP_Graf; RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences ...
      cd01249
      Location:164269
      BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
      cl12013
      Location:1122
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
      cl25496
      Location:472618
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    7. XM_017313014.1XP_017168503.1  rho GTPase-activating protein 10 isoform X1

    8. XM_017313019.1XP_017168508.1  rho GTPase-activating protein 10 isoform X9

    9. XM_017313021.1XP_017168510.1  rho GTPase-activating protein 10 isoform X11

      Conserved Domains (4) summary
      cd12065
      Location:578631
      SH3_GRAF2; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase 2
      cd04374
      Location:264466
      RhoGAP_Graf; RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences ...
      cd01249
      Location:164269
      BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
      cl12013
      Location:1122
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    10. XM_017313018.1XP_017168507.1  rho GTPase-activating protein 10 isoform X8

      Conserved Domains (5) summary
      cd12065
      Location:607660
      SH3_GRAF2; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase 2
      cd01249
      Location:164269
      BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
      cl02570
      Location:264444
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
      cl12013
      Location:1122
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
      cl25496
      Location:450596
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    11. XM_006531498.3XP_006531561.1  rho GTPase-activating protein 10 isoform X6

      UniProtKB/Swiss-Prot
      Q6Y5D8
      Related
      ENSMUSP00000147485.1, ENSMUST00000210922.1
      Conserved Domains (4) summary
      cd12065
      Location:681734
      SH3_GRAF2; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase 2
      cd04374
      Location:367569
      RhoGAP_Graf; RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences ...
      cd01249
      Location:267372
      BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
      cl12013
      Location:19225
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    12. XM_006531495.3XP_006531558.1  rho GTPase-activating protein 10 isoform X2

      UniProtKB/Swiss-Prot
      Q6Y5D8
      Related
      ENSMUSP00000147493.1, ENSMUST00000210519.1
      Conserved Domains (5) summary
      cd12065
      Location:710763
      SH3_GRAF2; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase 2
      cd01249
      Location:267372
      BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
      cl02570
      Location:367547
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
      cl12013
      Location:19225
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
      cl25496
      Location:553699
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    13. XM_017313022.1XP_017168511.1  rho GTPase-activating protein 10 isoform X12

    RNA

    1. XR_001778487.1 RNA Sequence

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