U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Adgrf4 adhesion G protein-coupled receptor F4 [ Mus musculus (house mouse) ]

    Gene ID: 78249, updated on 26-Sep-2022

    Summary

    Official Symbol
    Adgrf4provided by MGI
    Official Full Name
    adhesion G protein-coupled receptor F4provided by MGI
    Primary source
    MGI:MGI:1925499
    See related
    Ensembl:ENSMUSG00000023918 AllianceGenome:MGI:1925499
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gpr115; 4632435A09Rik
    Summary
    Predicted to enable G protein-coupled receptor activity. Acts upstream of or within erythrocyte development; glomerular filtration; and pharyngeal arch artery morphogenesis. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in several structures, including genitourinary system; heart; lung; skin; and thymus. Orthologous to human ADGRF4 (adhesion G protein-coupled receptor F4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in frontal lobe adult (RPKM 1.5), stomach adult (RPKM 1.3) and 16 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Adgrf4 in Genome Data Viewer
    Location:
    17; 17 B3
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (42967099..43008460, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (42656208..42697569, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene serine palmitoyltransferase small subunit A pseudogene Neighboring gene patched domain containing 4 Neighboring gene opsin 5 Neighboring gene adhesion G protein-coupled receptor F2 Neighboring gene 40S ribosomal protein S2 pseudogene Neighboring gene CD2-associated protein

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Markers

    Homology

    Clone Names

    • MGC107333, MGC175941

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    adhesion G protein-coupled receptor F4
    Names
    G protein coupled receptor Gpr115
    G protein-coupled receptor 115
    probable G-protein coupled receptor 115

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289499.1NP_001276428.1  adhesion G protein-coupled receptor F4 precursor

      See identical proteins and their annotated locations for NP_001276428.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein.
      Source sequence(s)
      AK019508, BY714064, D18369
      Consensus CDS
      CCDS50113.1
      UniProtKB/Swiss-Prot
      Q9D2L6
      UniProtKB/TrEMBL
      A0A0D9SEG9
      Related
      ENSMUSP00000132890.2, ENSMUST00000167993.8
      Conserved Domains (3) summary
      cd14964
      Location:405429
      7tm_GPCRs; TM helix 1 [structural motif]
      pfam01825
      Location:351394
      GPS; GPCR proteolysis site, GPS, motif
      cl28897
      Location:402669
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    2. NM_001289500.1NP_001276429.1  adhesion G protein-coupled receptor F4 precursor

      See identical proteins and their annotated locations for NP_001276429.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein.
      Source sequence(s)
      AK019508, BY714064, D18369
      Consensus CDS
      CCDS50113.1
      UniProtKB/Swiss-Prot
      Q9D2L6
      UniProtKB/TrEMBL
      A0A0D9SEG9
      Related
      ENSMUSP00000133261.2, ENSMUST00000170723.8
      Conserved Domains (3) summary
      cd14964
      Location:405429
      7tm_GPCRs; TM helix 1 [structural motif]
      pfam01825
      Location:351394
      GPS; GPCR proteolysis site, GPS, motif
      cl28897
      Location:402669
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    3. NM_001289501.1NP_001276430.1  adhesion G protein-coupled receptor F4 precursor

      See identical proteins and their annotated locations for NP_001276430.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein.
      Source sequence(s)
      AK019508, BY142177, BY714064, D18369
      Consensus CDS
      CCDS50113.1
      UniProtKB/Swiss-Prot
      Q9D2L6
      UniProtKB/TrEMBL
      A0A0D9SEG9
      Conserved Domains (3) summary
      cd14964
      Location:405429
      7tm_GPCRs; TM helix 1 [structural motif]
      pfam01825
      Location:351394
      GPS; GPCR proteolysis site, GPS, motif
      cl28897
      Location:402669
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    4. NM_030067.2NP_084343.1  adhesion G protein-coupled receptor F4 precursor

      See identical proteins and their annotated locations for NP_084343.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3, and 4 encode the same protein.
      Source sequence(s)
      AK019508, D18369
      Consensus CDS
      CCDS50113.1
      UniProtKB/Swiss-Prot
      Q9D2L6
      UniProtKB/TrEMBL
      A0A0D9SEG9
      Related
      ENSMUSP00000024711.5, ENSMUST00000024711.11
      Conserved Domains (3) summary
      cd14964
      Location:405429
      7tm_GPCRs; TM helix 1 [structural motif]
      pfam01825
      Location:351394
      GPS; GPCR proteolysis site, GPS, motif
      cl28897
      Location:402669
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      42967099..43008460 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017317725.2XP_017173214.1  adhesion G protein-coupled receptor F4 isoform X1

      UniProtKB/Swiss-Prot
      Q9D2L6
      UniProtKB/TrEMBL
      A0A0D9SEG9
      Conserved Domains (3) summary
      cd14964
      Location:405429
      7tm_GPCRs; TM helix 1 [structural motif]
      pfam01825
      Location:351394
      GPS; GPCR proteolysis site, GPS, motif
      cl28897
      Location:402669
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily