U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    EVI5 ecotropic viral integration site 5 [ Homo sapiens (human) ]

    Gene ID: 7813, updated on 17-Jun-2024

    Summary

    Official Symbol
    EVI5provided by HGNC
    Official Full Name
    ecotropic viral integration site 5provided by HGNC
    Primary source
    HGNC:HGNC:3501
    See related
    Ensembl:ENSG00000067208 MIM:602942; AllianceGenome:HGNC:3501
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NB4S; EVI-5
    Summary
    Enables GTPase activator activity and small GTPase binding activity. Involved in positive regulation of GTPase activity and retrograde transport, endosome to Golgi. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis (RPKM 3.8), placenta (RPKM 3.5) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See EVI5 in Genome Data Viewer
    Location:
    1p22.1
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (92508696..92792410, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (92353585..92637609, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (92974253..93257967, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 824, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1314 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1070 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:92948665-92949264 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:92949865-92950465 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:92951066-92951666 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1075 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1316 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1074 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1317 Neighboring gene growth factor independent 1 transcriptional repressor Neighboring gene succinate dehydrogenase assembly factor 3, mitochondrial-like Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1076 Neighboring gene Sharpr-MPRA regulatory region 13174 Neighboring gene high mobility group box 3 pseudogene 9 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:93158253-93158754 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:93189334-93189860 Neighboring gene RNA, U4 small nuclear 59, pseudogene Neighboring gene zinc finger AN1-type containing 1 pseudogene Neighboring gene NANOG hESC enhancer GRCh37_chr1:93239902-93240565 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1077 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1318 Neighboring gene cyclin J pseudogene 2 Neighboring gene H3 histone pseudogene 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1319 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:93297399-93298037 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:93298038-93298675 Neighboring gene small nucleolar RNA, C/D box 21 Neighboring gene divergent protein kinase domain 1A Neighboring gene small nucleolar RNA, H/ACA box 66 Neighboring gene ribosomal protein L5

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Biological, clinical and population relevance of 95 loci for blood lipids.
    EBI GWAS Catalog
    Discovery and refinement of loci associated with lipid levels.
    EBI GWAS Catalog
    Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
    EBI GWAS Catalog
    Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTPase activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables small GTPase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in activation of GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of GTPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT involved_in regulation of cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in retrograde transport, endosome to Golgi IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in spindle IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    ecotropic viral integration site 5 protein homolog
    Names
    dJ846D11.1 (ecotropic viral integration site 5)
    neuroblastoma stage 4S gene protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001308248.2NP_001295177.1  ecotropic viral integration site 5 protein homolog isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC104332, AC104456, AL133332, AL354890
      Consensus CDS
      CCDS76179.1
      UniProtKB/TrEMBL
      A0A9L9PXM6
      Related
      ENSP00000440826.2, ENST00000540033.3
      Conserved Domains (3) summary
      smart00164
      Location:160368
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      pfam07960
      Location:511606
      CBP4; CBP4
      cl11555
      Location:464504
      DUF1129; Protein of unknown function (DUF1129)
    2. NM_001350197.2NP_001337126.1  ecotropic viral integration site 5 protein homolog isoform 3

      Status: VALIDATED

      Source sequence(s)
      AA725529, AB209513, AB449875, AC104332, AC104456, BM835541, BP282704, BX369930, BX378682, CN334472
      Consensus CDS
      CCDS91002.1
      UniProtKB/TrEMBL
      A0A804HIC4, A0A9L9PXM6
      Related
      ENSP00000506999.1, ENST00000684568.2
      Conserved Domains (2) summary
      smart00164
      Location:116324
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      cl25732
      Location:349693
      SMC_N; RecF/RecN/SMC N terminal domain
    3. NM_001350198.2NP_001337127.1  ecotropic viral integration site 5 protein homolog isoform 4

      Status: VALIDATED

      Source sequence(s)
      AA725529, AB209513, AB449875, AC104332, AC104456, BM835541, BP282704, BX378682, CN334472
      UniProtKB/TrEMBL
      A0A9L9PXM6, A0A9L9PYE8
      Related
      ENSP00000516595.1, ENST00000706868.1
      Conserved Domains (2) summary
      smart00164
      Location:116324
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      cl25732
      Location:349693
      SMC_N; RecF/RecN/SMC N terminal domain
    4. NM_001377210.1NP_001364139.1  ecotropic viral integration site 5 protein homolog isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC104332, AC104456, AL354890
      UniProtKB/TrEMBL
      A0A9L9PXL1, A0A9L9PXM6
      Related
      ENSP00000516584.1, ENST00000706843.1
      Conserved Domains (2) summary
      smart00164
      Location:157365
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      COG1196
      Location:358631
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    5. NM_001377211.1NP_001364140.1  ecotropic viral integration site 5 protein homolog isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC104332, AC104456, AL354890
      Conserved Domains (2) summary
      smart00164
      Location:116324
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      TIGR02168
      Location:380673
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    6. NM_001377212.1NP_001364141.1  ecotropic viral integration site 5 protein homolog isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC104332, AC104456, AL354890
      UniProtKB/TrEMBL
      A0A9L9PXM6
      Conserved Domains (2) summary
      smart00164
      Location:116324
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      COG1196
      Location:317590
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    7. NM_001377213.1NP_001364142.1  ecotropic viral integration site 5 protein homolog isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC104332, AC104456, AL354890
      UniProtKB/TrEMBL
      A0A9L9PXE3, A0A9L9PXM6
      Related
      ENSP00000516594.1, ENST00000706867.1
      Conserved Domains (2) summary
      smart00164
      Location:143351
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      COG1196
      Location:376720
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    8. NM_005665.6NP_005656.4  ecotropic viral integration site 5 protein homolog isoform 2

      See identical proteins and their annotated locations for NP_005656.4

      Status: VALIDATED

      Source sequence(s)
      AA725529, AB209513, AC104332, AC104456, AF008915, AL133332, CN334472
      Consensus CDS
      CCDS30774.1
      UniProtKB/Swiss-Prot
      A6NKX8, B9A6J0, O60447, Q9H1Y9
      UniProtKB/TrEMBL
      A0A9L9PXM6
      Related
      ENSP00000359356.1, ENST00000370331.5
      Conserved Domains (3) summary
      smart00164
      Location:160368
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      pfam07960
      Location:500595
      CBP4; CBP4
      cl11555
      Location:453493
      DUF1129; Protein of unknown function (DUF1129)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      92508696..92792410 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047430054.1XP_047286010.1  ecotropic viral integration site 5 protein homolog isoform X11

      UniProtKB/TrEMBL
      A0A9L9PXM6
    2. XM_017002277.2XP_016857766.1  ecotropic viral integration site 5 protein homolog isoform X8

      UniProtKB/TrEMBL
      A0A9L9PXM6
    3. XM_024449686.2XP_024305454.1  ecotropic viral integration site 5 protein homolog isoform X7

      UniProtKB/TrEMBL
      A0A9L9PXM6
      Conserved Domains (2) summary
      smart00164
      Location:160368
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      cl25732
      Location:393737
      SMC_N; RecF/RecN/SMC N terminal domain
    4. XM_017002271.3XP_016857760.1  ecotropic viral integration site 5 protein homolog isoform X3

      UniProtKB/TrEMBL
      A0A9L9PXM6
    5. XM_024449689.2XP_024305457.1  ecotropic viral integration site 5 protein homolog isoform X13

      UniProtKB/TrEMBL
      A0A9L9PXM6
      Conserved Domains (2) summary
      smart00164
      Location:187395
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      cl25732
      Location:433745
      SMC_N; RecF/RecN/SMC N terminal domain
    6. XM_017002278.2XP_016857767.1  ecotropic viral integration site 5 protein homolog isoform X10

      UniProtKB/TrEMBL
      A0A9L9PXM6
    7. XM_017002272.2XP_016857761.1  ecotropic viral integration site 5 protein homolog isoform X5

      UniProtKB/TrEMBL
      A0A9L9PXM6
      Conserved Domains (2) summary
      smart00164
      Location:187395
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      COG1196
      Location:420764
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    8. XM_017002269.2XP_016857758.1  ecotropic viral integration site 5 protein homolog isoform X1

      UniProtKB/TrEMBL
      A0A9L9PXM6
    9. XM_017002282.2XP_016857771.1  ecotropic viral integration site 5 protein homolog isoform X15

    10. XM_017002286.3XP_016857775.1  ecotropic viral integration site 5 protein homolog isoform X16

      UniProtKB/TrEMBL
      A0A9L9PXM6
      Conserved Domains (2) summary
      smart00164
      Location:2187
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      COG1196
      Location:212556
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    11. XM_017002273.3XP_016857762.1  ecotropic viral integration site 5 protein homolog isoform X6

      UniProtKB/TrEMBL
      A0A9L9PXM6
      Conserved Domains (3) summary
      smart00164
      Location:143351
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      pfam07960
      Location:543638
      CBP4; CBP4
      cl11555
      Location:496536
      DUF1129; Protein of unknown function (DUF1129)
    12. XM_047430051.1XP_047286007.1  ecotropic viral integration site 5 protein homolog isoform X9

      UniProtKB/TrEMBL
      A0A9L9PXM6
    13. XM_047430040.1XP_047285996.1  ecotropic viral integration site 5 protein homolog isoform X4

      UniProtKB/TrEMBL
      A0A9L9PXM6
    14. XM_017002270.3XP_016857759.1  ecotropic viral integration site 5 protein homolog isoform X2

      UniProtKB/TrEMBL
      A0A9L9PXM6
      Conserved Domains (3) summary
      smart00164
      Location:184392
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      pfam07960
      Location:584679
      CBP4; CBP4
      cl11555
      Location:537577
      DUF1129; Protein of unknown function (DUF1129)
    15. XM_017002274.1XP_016857763.1  ecotropic viral integration site 5 protein homolog isoform X6

      UniProtKB/TrEMBL
      A0A9L9PXM6
      Conserved Domains (3) summary
      smart00164
      Location:143351
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      pfam07960
      Location:543638
      CBP4; CBP4
      cl11555
      Location:496536
      DUF1129; Protein of unknown function (DUF1129)
    16. XM_017002275.1XP_016857764.1  ecotropic viral integration site 5 protein homolog isoform X6

      UniProtKB/TrEMBL
      A0A9L9PXM6
      Conserved Domains (3) summary
      smart00164
      Location:143351
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      pfam07960
      Location:543638
      CBP4; CBP4
      cl11555
      Location:496536
      DUF1129; Protein of unknown function (DUF1129)
    17. XM_024449690.2XP_024305458.1  ecotropic viral integration site 5 protein homolog isoform X14

      UniProtKB/TrEMBL
      A0A9L9PXM6
      Conserved Domains (2) summary
      smart00164
      Location:71279
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      cl25732
      Location:304648
      SMC_N; RecF/RecN/SMC N terminal domain
    18. XM_017002279.2XP_016857768.1  ecotropic viral integration site 5 protein homolog isoform X12

      UniProtKB/TrEMBL
      A0A9L9PXM6
    19. XM_017002288.1XP_016857777.1  ecotropic viral integration site 5 protein homolog isoform X16

      UniProtKB/TrEMBL
      A0A9L9PXM6
      Conserved Domains (2) summary
      smart00164
      Location:2187
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      COG1196
      Location:212556
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    RNA

    1. XR_001737401.2 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      92353585..92637609 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)