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    PTP4A1 protein tyrosine phosphatase 4A1 [ Homo sapiens (human) ]

    Gene ID: 7803, updated on 17-Jun-2024

    Summary

    Official Symbol
    PTP4A1provided by HGNC
    Official Full Name
    protein tyrosine phosphatase 4A1provided by HGNC
    Primary source
    HGNC:HGNC:9634
    See related
    Ensembl:ENSG00000112245 MIM:601585; AllianceGenome:HGNC:9634
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HH72; PRL1; PRL-1; PTPCAAX1; PTP(CAAX1)
    Summary
    This gene encodes a member of a small class of prenylated protein tyrosine phosphatases (PTPs), which contain a PTP domain and a characteristic C-terminal prenylation motif. The encoded protein is a cell signaling molecule that plays regulatory roles in a variety of cellular processes, including cell proliferation and migration. The protein may also be involved in cancer development and metastasis. This tyrosine phosphatase is a nuclear protein, but may associate with plasma membrane by means of its prenylation motif. Pseudogenes related to this gene are located on chromosomes 1, 2, 5, 7, 11 and X. [provided by RefSeq, Jun 2013]
    Expression
    Broad expression in liver (RPKM 141.5), adrenal (RPKM 72.5) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See PTP4A1 in Genome Data Viewer
    Location:
    6q12
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (63516440..63583588)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (64662355..64729529)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (64226345..64293493)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene HNF1 motif-containing MPRA enhancer 15 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24717 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24718 Neighboring gene leucine rich repeat containing 59 pseudogene Neighboring gene lengsin, lens protein with glutamine synthetase domain Neighboring gene translation initiation factor IF-2-like Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:64282845-64283580 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:64283581-64284316 Neighboring gene uncharacterized LOC128125822 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:64282109-64282844 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:64281371-64282108 Neighboring gene Sharpr-MPRA regulatory region 1413 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24720 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24721 Neighboring gene eukaryotic translation elongation factor 1 beta 2 pseudogene 5 Neighboring gene NANOG hESC enhancer GRCh37_chr6:64344395-64344932 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:64345464-64346284 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17311 Neighboring gene ribosomal protein L7a pseudogene 34 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24722 Neighboring gene ribosomal protein L9 pseudogene 18 Neighboring gene PHD finger protein 3 Neighboring gene eyes shut homolog

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • DKFZp779M0721

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein tyrosine phosphatase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasmic side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in early endosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in spindle IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    protein tyrosine phosphatase type IVA 1
    Names
    PVT1/PTP4A1 fusion
    phosphatase of regenerating liver 1
    protein tyrosine phosphatase type IVA protein 1
    protein tyrosine phosphatase type IVA, member 1
    protein-tyrosine phosphatase of regenerating liver 1
    NP_001372183.1
    NP_001372184.1
    NP_001372185.1
    NP_001372186.1
    NP_001372187.1
    NP_001372188.1
    NP_001372189.1
    NP_001372191.1
    NP_001372192.1
    NP_001372194.1
    NP_001372195.1
    NP_001372196.1
    NP_001372197.1
    NP_003454.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001385254.1NP_001372183.1  protein tyrosine phosphatase type IVA 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL135905
      Consensus CDS
      CCDS4965.1
      UniProtKB/Swiss-Prot
      B2R6C8, O00648, Q49A54, Q93096
      UniProtKB/TrEMBL
      B5BU78
      Conserved Domains (1) summary
      cd18537
      Location:1167
      PTP-IVa1; protein tyrosine phosphatase type IVA 1
    2. NM_001385255.1NP_001372184.1  protein tyrosine phosphatase type IVA 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL135905
      Consensus CDS
      CCDS4965.1
      UniProtKB/Swiss-Prot
      B2R6C8, O00648, Q49A54, Q93096
      UniProtKB/TrEMBL
      B5BU78
      Conserved Domains (1) summary
      cd18537
      Location:1167
      PTP-IVa1; protein tyrosine phosphatase type IVA 1
    3. NM_001385256.1NP_001372185.1  protein tyrosine phosphatase type IVA 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL135905
      Consensus CDS
      CCDS4965.1
      UniProtKB/Swiss-Prot
      B2R6C8, O00648, Q49A54, Q93096
      UniProtKB/TrEMBL
      B5BU78
      Related
      ENSP00000497588.1, ENST00000648894.1
      Conserved Domains (1) summary
      cd18537
      Location:1167
      PTP-IVa1; protein tyrosine phosphatase type IVA 1
    4. NM_001385257.1NP_001372186.1  protein tyrosine phosphatase type IVA 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL135905
      Consensus CDS
      CCDS4965.1
      UniProtKB/Swiss-Prot
      B2R6C8, O00648, Q49A54, Q93096
      UniProtKB/TrEMBL
      B5BU78
      Conserved Domains (1) summary
      cd18537
      Location:1167
      PTP-IVa1; protein tyrosine phosphatase type IVA 1
    5. NM_001385258.1NP_001372187.1  protein tyrosine phosphatase type IVA 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL135905
      Consensus CDS
      CCDS4965.1
      UniProtKB/Swiss-Prot
      B2R6C8, O00648, Q49A54, Q93096
      UniProtKB/TrEMBL
      B5BU78
      Conserved Domains (1) summary
      cd18537
      Location:1167
      PTP-IVa1; protein tyrosine phosphatase type IVA 1
    6. NM_001385259.1NP_001372188.1  protein tyrosine phosphatase type IVA 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL135905
      Consensus CDS
      CCDS4965.1
      UniProtKB/Swiss-Prot
      B2R6C8, O00648, Q49A54, Q93096
      UniProtKB/TrEMBL
      B5BU78
      Related
      ENSP00000500859.1, ENST00000673199.1
      Conserved Domains (1) summary
      cd18537
      Location:1167
      PTP-IVa1; protein tyrosine phosphatase type IVA 1
    7. NM_001385260.1NP_001372189.1  protein tyrosine phosphatase type IVA 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL135905
      Consensus CDS
      CCDS4965.1
      UniProtKB/Swiss-Prot
      B2R6C8, O00648, Q49A54, Q93096
      UniProtKB/TrEMBL
      B5BU78
      Related
      ENSP00000500952.1, ENST00000672924.1
      Conserved Domains (1) summary
      cd18537
      Location:1167
      PTP-IVa1; protein tyrosine phosphatase type IVA 1
    8. NM_001385262.2NP_001372191.1  protein tyrosine phosphatase type IVA 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL135905
      Consensus CDS
      CCDS4965.1
      UniProtKB/Swiss-Prot
      B2R6C8, O00648, Q49A54, Q93096
      UniProtKB/TrEMBL
      B5BU78
      Conserved Domains (1) summary
      cd18537
      Location:1167
      PTP-IVa1; protein tyrosine phosphatase type IVA 1
    9. NM_001385263.2NP_001372192.1  protein tyrosine phosphatase type IVA 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL135905
      UniProtKB/TrEMBL
      B5BU78
      Conserved Domains (1) summary
      cl28904
      Location:1151
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
    10. NM_001385265.1NP_001372194.1  protein tyrosine phosphatase type IVA 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL135905
      Conserved Domains (1) summary
      cl28904
      Location:1135
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
    11. NM_001385266.1NP_001372195.1  protein tyrosine phosphatase type IVA 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL135905
      Conserved Domains (1) summary
      cl28904
      Location:1135
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
    12. NM_001385267.2NP_001372196.1  protein tyrosine phosphatase type IVA 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL135905
      Consensus CDS
      CCDS4965.1
      UniProtKB/Swiss-Prot
      B2R6C8, O00648, Q49A54, Q93096
      UniProtKB/TrEMBL
      B5BU78
      Conserved Domains (1) summary
      cd18537
      Location:1167
      PTP-IVa1; protein tyrosine phosphatase type IVA 1
    13. NM_001385268.2NP_001372197.1  protein tyrosine phosphatase type IVA 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL135905
      UniProtKB/TrEMBL
      B5BU78
      Conserved Domains (1) summary
      cl28904
      Location:1154
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
    14. NM_003463.5NP_003454.1  protein tyrosine phosphatase type IVA 1 isoform 1

      See identical proteins and their annotated locations for NP_003454.1

      Status: VALIDATED

      Source sequence(s)
      AL135905
      Consensus CDS
      CCDS4965.1
      UniProtKB/Swiss-Prot
      B2R6C8, O00648, Q49A54, Q93096
      UniProtKB/TrEMBL
      B5BU78
      Related
      ENSP00000485687.1, ENST00000626021.3
      Conserved Domains (1) summary
      cd18537
      Location:1167
      PTP-IVa1; protein tyrosine phosphatase type IVA 1

    RNA

    1. NR_169593.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL135905
    2. NR_169594.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL135905
    3. NR_169595.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL135905
    4. NR_169596.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL135905

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      63516440..63583588
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      64662355..64729529
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)