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    Ascc3 activating signal cointegrator 1 complex subunit 3 [ Mus musculus (house mouse) ]

    Gene ID: 77987, updated on 31-Jan-2019

    Summary

    Official Symbol
    Ascc3provided by MGI
    Official Full Name
    activating signal cointegrator 1 complex subunit 3provided by MGI
    Primary source
    MGI:MGI:1925237
    See related
    Ensembl:ENSMUSG00000038774
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    RNAH; Helic1; ASC1p200; BC023451; D630041L21; B630009I04Rik; D430001L07Rik
    Expression
    Ubiquitous expression in placenta adult (RPKM 4.7), liver E14 (RPKM 3.6) and 28 other tissues See more
    Orthologs

    Genomic context

    See Ascc3 in Genome Data Viewer
    Location:
    10; 10 B3
    Exon count:
    42
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 10 NC_000076.6 (50592669..50851202)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (50312475..50571008)

    Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene Neighboring gene predicted gene, 46199 Neighboring gene ribosomal protein L15 pseudogene Neighboring gene RIKEN cDNA A230054N11 gene Neighboring gene single-minded family bHLH transcription factor 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    ATP-dependent 3'-5' DNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ATP-dependent 3'-5' DNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
     
    ATP-dependent helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    DNA dealkylation involved in DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    DNA dealkylation involved in DNA repair ISO
    Inferred from Sequence Orthology
    more info
     
    DNA duplex unwinding ISO
    Inferred from Sequence Orthology
    more info
     
    DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to DNA damage stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    activating signal cointegrator 1 complex ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    activating signal cointegrator 1 complex subunit 3
    Names
    helicase, ATP binding 1
    NP_932124.2
    XP_006512986.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_198007.2NP_932124.2  activating signal cointegrator 1 complex subunit 3

      See identical proteins and their annotated locations for NP_932124.2

      Status: VALIDATED

      Source sequence(s)
      AC137877, AC153529, AC159114
      Consensus CDS
      CCDS48555.1
      UniProtKB/Swiss-Prot
      E9PZJ8
      Related
      ENSMUSP00000036726.8, ENSMUST00000035606.9
      Conserved Domains (5) summary
      smart00490
      Location:16151694
      HELICc; helicase superfamily c-terminal domain
      smart00611
      Location:18102179
      SEC63; Domain of unknown function in Sec63p, Brr2p and other proteins
      COG1204
      Location:4611240
      BRR2; Replicative superfamily II helicase [Replication, recombination and repair]
      pfam00270
      Location:13291500
      DEAD; DEAD/DEAH box helicase
      pfam02889
      Location:9791287
      Sec63; Sec63 Brl domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000076.6 Reference GRCm38.p4 C57BL/6J

      Range
      50592669..50851202
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006512923.3XP_006512986.1  activating signal cointegrator 1 complex subunit 3 isoform X1

      Conserved Domains (5) summary
      smart00490
      Location:15171596
      HELICc; helicase superfamily c-terminal domain
      smart00611
      Location:17122078
      SEC63; Domain of unknown function in Sec63p, Brr2p and other proteins
      COG1204
      Location:3631142
      BRR2; Replicative superfamily II helicase [Replication, recombination and repair]
      pfam00270
      Location:12311402
      DEAD; DEAD/DEAH box helicase
      pfam02889
      Location:8811189
      Sec63; Sec63 Brl domain
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