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    Hook1 hook microtubule tethering protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 77963, updated on 23-Jun-2021

    Summary

    Official Symbol
    Hook1provided by MGI
    Official Full Name
    hook microtubule tethering protein 1provided by MGI
    Primary source
    MGI:MGI:1925213
    See related
    Ensembl:ENSMUSG00000028572
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    az; azh; A930033L17Rik
    Expression
    Broad expression in testis adult (RPKM 19.9), CNS E18 (RPKM 15.8) and 22 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Hook1 in Genome Data Viewer
    Location:
    4 C5; 4 44.17 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (95855418..95913649)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (95967181..96025412)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (95634070..95690968)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40206 Neighboring gene FGGY carbohydrate kinase domain containing Neighboring gene RIKEN cDNA 9530080O11 gene Neighboring gene cytochrome P450, family 2, subfamily j, polypeptide 13 Neighboring gene heat shock protein 1 (chaperonin 10), pseudogene 6 Neighboring gene cytochrome P450, family 2, subfamily j, polypeptide 12

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Radiation induced (1) 
    • Endonuclease-mediated (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables dynein light intermediate chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables microtubule binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within Golgi organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cytoplasmic microtubule organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within cytoplasmic microtubule organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cytoskeleton-dependent intracellular transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in early endosome to late endosome transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endosome organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endosome to lysosome transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lysosome organization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within manchette assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein localization to perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within spermatid development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of FHF complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of HOPS complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    located_in microtubule cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    protein Hook homolog 1
    Names
    abnormal spermatozoon head shape
    hook homolog 1
    mHK1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_030014.2NP_084290.1  protein Hook homolog 1

      See identical proteins and their annotated locations for NP_084290.1

      Status: PROVISIONAL

      Source sequence(s)
      BC061688
      Consensus CDS
      CCDS18367.1
      UniProtKB/Swiss-Prot
      Q8BIL5
      Related
      ENSMUSP00000030306.8, ENSMUST00000030306.14
      Conserved Domains (3) summary
      pfam05622
      Location:14720
      HOOK; HOOK protein
      pfam11221
      Location:175210
      Med21; Subunit 21 of Mediator complex
      cl19219
      Location:502584
      DUF342; Protein of unknown function (DUF342)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      95855418..95913649
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006503488.4XP_006503551.1  protein Hook homolog 1 isoform X3

      Conserved Domains (1) summary
      pfam05622
      Location:14546
      HOOK; HOOK protein
    2. XM_006503487.4XP_006503550.1  protein Hook homolog 1 isoform X2

      Conserved Domains (1) summary
      pfam05622
      Location:14534
      HOOK; HOOK protein
    3. XM_030253920.2XP_030109780.1  protein Hook homolog 1 isoform X1

      Conserved Domains (1) summary
      pfam05622
      Location:1678
      HOOK; HOOK protein

    RNA

    1. XR_001784219.2 RNA Sequence

    2. XR_001784220.2 RNA Sequence

    3. XR_376377.4 RNA Sequence

    4. XR_376374.4 RNA Sequence

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