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    Msl2 MSL complex subunit 2 [ Mus musculus (house mouse) ]

    Gene ID: 77853, updated on 23-Jun-2021

    Summary

    Official Symbol
    Msl2provided by MGI
    Official Full Name
    MSL complex subunit 2provided by MGI
    Primary source
    MGI:MGI:1925103
    See related
    Ensembl:ENSMUSG00000066415
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Msl; Rnf1; Msl2l1; Rnf184; E130103E02Rik
    Expression
    Ubiquitous expression in thymus adult (RPKM 14.4), spleen adult (RPKM 9.6) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Msl2 in Genome Data Viewer
    Location:
    9; 9 E4
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (100956107..100981999)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (101074054..101104800)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (100978451..100979143) , (101002900..101007130)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene brain expressed X-linked 2 pseudogene Neighboring gene predicted gene, 46140 Neighboring gene protein phosphatase 2, regulatory subunit B'', alpha Neighboring gene predicted gene, 24338 Neighboring gene ubiquitin-conjugating enzyme E2 variant 1 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in histone H4-K16 acetylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in histone H4-K16 acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of MSL complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of MSL complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase MSL2
    Names
    E3 ubiquitin-protein transferase MSL2
    MSL2-like 1
    male-specific lethal 2 homolog
    male-specific lethal 2-like 1
    male-specific lethal-2 homolog 1
    ring finger protein 184

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100451.2NP_001093921.1  E3 ubiquitin-protein ligase MSL2 isoform 1

      See identical proteins and their annotated locations for NP_001093921.1

      Status: VALIDATED

      Source sequence(s)
      AK035934, BC070432, BC100371, BE986573
      Consensus CDS
      CCDS85717.1
      UniProtKB/Swiss-Prot
      Q69ZF8
      Related
      ENSMUSP00000082270.4, ENSMUST00000085177.5
      Conserved Domains (2) summary
      cd13122
      Location:456505
      MSL2_CXC; DNA-binding cysteine-rich domain of male-specific lethal 2 and related proteins
      pfam16685
      Location:42111
      zf-RING_10; zinc RING finger of MSL2
    2. NM_001379344.1NP_001366273.1  E3 ubiquitin-protein ligase MSL2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC242670, AC242673
      Conserved Domains (3) summary
      TIGR03551
      Location:170212
      F420_cofH; 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase, CofH subunit
      pfam16682
      Location:381435
      MSL2-CXC; CXC domain of E3 ubiquitin-protein ligase MSL2
      cl17238
      Location:137
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      100956107..100981999
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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