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    SLC30A2 solute carrier family 30 member 2 [ Homo sapiens (human) ]

    Gene ID: 7780, updated on 2-Nov-2024

    Summary

    Official Symbol
    SLC30A2provided by HGNC
    Official Full Name
    solute carrier family 30 member 2provided by HGNC
    Primary source
    HGNC:HGNC:11013
    See related
    Ensembl:ENSG00000158014 MIM:609617; AllianceGenome:HGNC:11013
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TNZD; ZNT2; ZnT-2; PP12488
    Summary
    The protein encoded by this gene is a zinc transporter that acts as a homodimer. The encoded protein plays a role in secreting zinc into breast milk. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2015]
    Expression
    Biased expression in thyroid (RPKM 19.5), kidney (RPKM 11.8) and 4 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See SLC30A2 in Genome Data Viewer
    Location:
    1p36.11
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (26037252..26046118, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (25874654..25883519, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (26363743..26372609, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene small Cajal body-specific RNA 18 Neighboring gene exostosin like glycosyltransferase 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:26355537-26356402 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:26360876-26361606 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:26361909-26362072 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 475 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 476 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 477 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 478 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:26371640-26372208 Neighboring gene uncharacterized LOC105376910 Neighboring gene Sharpr-MPRA regulatory region 4919 Neighboring gene tripartite motif containing 63

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ36708, MGC11303

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables zinc ion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables zinc ion transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables zinc:proton antiporter activity IC
    Inferred by Curator
    more info
    PubMed 
    enables zinc:proton antiporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in intracellular zinc ion homeostasis IC
    Inferred by Curator
    more info
    PubMed 
    involved_in response to zinc ion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in zinc export across plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in zinc ion import into lysosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in zinc ion import into lysosome IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in zinc ion import into mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in zinc ion import into organelle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in zinc ion import into organelle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in zinc ion import into secretory vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in zinc ion import into zymogen granule ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in zinc ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endosome membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endosome membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    located_in late endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lysosomal membrane HDA PubMed 
    located_in lysosomal membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in secretory vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in transport vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in zymogen granule membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    proton-coupled zinc antiporter SLC30A2
    Names
    solute carrier family 30 (zinc transporter), member 2
    zinc transporter 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_042808.1 RefSeqGene

      Range
      5021..13887
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001004434.3NP_001004434.1  proton-coupled zinc antiporter SLC30A2 isoform 1

      See identical proteins and their annotated locations for NP_001004434.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AF370409, AI161067, AL391650, DR004258
      Consensus CDS
      CCDS30644.1
      UniProtKB/Swiss-Prot
      Q71RC8, Q9BRI3
      Related
      ENSP00000363394.3, ENST00000374276.4
      Conserved Domains (2) summary
      TIGR01297
      Location:83357
      CDF; cation diffusion facilitator family transporter
      pfam01545
      Location:83278
      Cation_efflux; Cation efflux family
    2. NM_032513.5NP_115902.1  proton-coupled zinc antiporter SLC30A2 isoform 2

      See identical proteins and their annotated locations for NP_115902.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame segment, compared to variant 1, resulting in a shorter protein (isoform 2) that has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AF370409, AI161067, AL391650, BC006251, DR004258
      Consensus CDS
      CCDS272.1
      UniProtKB/Swiss-Prot
      Q9BRI3
      Related
      ENSP00000363396.3, ENST00000374278.7
      Conserved Domains (1) summary
      TIGR01297
      Location:91308
      CDF; cation diffusion facilitator family transporter

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      26037252..26046118 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      25874654..25883519 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)