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    Csrnp3 cysteine-serine-rich nuclear protein 3 [ Mus musculus (house mouse) ]

    Gene ID: 77771, updated on 31-Jan-2019

    Summary

    Official Symbol
    Csrnp3provided by MGI
    Official Full Name
    cysteine-serine-rich nuclear protein 3provided by MGI
    Primary source
    MGI:MGI:1925021
    See related
    Ensembl:ENSMUSG00000044647
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mbu1; Csnrp3; taip-2; CSRNP-3; A330102K23Rik
    Expression
    Biased expression in CNS E18 (RPKM 9.1), whole brain E14.5 (RPKM 8.2) and 7 other tissues See more
    Orthologs

    Genomic context

    See Csrnp3 in Genome Data Viewer
    Location:
    2; 2 C1.3
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (65845767..66031546)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (65683824..65869603)

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene sodium channel, voltage-gated, type III, alpha Neighboring gene predicted gene, 34833 Neighboring gene sodium channel, voltage-gated, type II, alpha Neighboring gene polypeptide N-acetylgalactosaminyltransferase 3 Neighboring gene tetratricopeptide repeat domain 21B

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    DNA-binding transcription activator activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    cysteine/serine-rich nuclear protein 3
    Names
    TGF-beta induced apoptosis protein 2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290665.1NP_001277594.1  cysteine/serine-rich nuclear protein 3 isoform b

      See identical proteins and their annotated locations for NP_001277594.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks three 5' exons but contains an alternate 5' terminal exon, and it thus differs in the 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a.
      Source sequence(s)
      AK158873, AL929230, AW492062
      Consensus CDS
      CCDS71060.1
      UniProtKB/Swiss-Prot
      P59055
      Related
      ENSMUSP00000135605.1, ENSMUST00000145598.8
      Conserved Domains (1) summary
      pfam16019
      Location:63277
      CSRNP_N; Cysteine/serine-rich nuclear protein N-terminus
    2. NM_001290666.1NP_001277595.1  cysteine/serine-rich nuclear protein 3 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks two alternate exons, and it thus differs in its 5' UTR and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (c) has a distinct N-terminus and is shorter than isoform a.
      Source sequence(s)
      AL929230, AW492062, BC055701, BY297754
      UniProtKB/TrEMBL
      Q7TNU4
      Conserved Domains (2) summary
      pfam16019
      Location:35180
      CSRNP_N; Cysteine/serine-rich nuclear protein N-terminus
      cl00310
      Location:371416
      AIRC; AIR carboxylase
    3. NM_153409.5NP_700458.3  cysteine/serine-rich nuclear protein 3 isoform a

      See identical proteins and their annotated locations for NP_700458.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Both variants 1 and 2 encode isoform a.
      Source sequence(s)
      AK039150, AL929230, BY297754, EF210820
      Consensus CDS
      CCDS16074.2
      UniProtKB/Swiss-Prot
      P59055
      Related
      ENSMUSP00000117533.1, ENSMUST00000122912.7
      Conserved Domains (1) summary
      pfam16019
      Location:75289
      CSRNP_N; Cysteine/serine-rich nuclear protein N-terminus
    4. NM_178634.2NP_848749.2  cysteine/serine-rich nuclear protein 3 isoform a

      See identical proteins and their annotated locations for NP_848749.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same isoform (a).
      Source sequence(s)
      AK082649, AL929230, BY297754, EF210820
      Consensus CDS
      CCDS16074.2
      UniProtKB/Swiss-Prot
      P59055
      Related
      ENSMUSP00000055719.3, ENSMUST00000053910.9
      Conserved Domains (1) summary
      pfam16019
      Location:75289
      CSRNP_N; Cysteine/serine-rich nuclear protein N-terminus

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

      Range
      65845767..66031546
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006500402.2XP_006500465.1  cysteine/serine-rich nuclear protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006500465.1

      UniProtKB/Swiss-Prot
      P59055
      Conserved Domains (1) summary
      pfam16019
      Location:63277
      CSRNP_N; Cysteine/serine-rich nuclear protein N-terminus
    2. XM_006500403.3XP_006500466.1  cysteine/serine-rich nuclear protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006500466.1

      UniProtKB/Swiss-Prot
      P59055
      Related
      ENSMUSP00000135019.1, ENSMUST00000176109.7
      Conserved Domains (1) summary
      pfam16019
      Location:63277
      CSRNP_N; Cysteine/serine-rich nuclear protein N-terminus
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