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    Apex2 apurinic/apyrimidinic endonuclease 2 [ Mus musculus (house mouse) ]

    Gene ID: 77622, updated on 22-Aug-2021

    Summary

    Official Symbol
    Apex2provided by MGI
    Official Full Name
    apurinic/apyrimidinic endonuclease 2provided by MGI
    Primary source
    MGI:MGI:1924872
    See related
    Ensembl:ENSMUSG00000025269
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ap; ape2; C430040P13Rik
    Expression
    Ubiquitous expression in liver E14.5 (RPKM 5.0), liver E14 (RPKM 4.2) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Apex2 in Genome Data Viewer
    Location:
    X; X F3
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) X NC_000086.8 (149286625..149371175, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (150426974..150588206, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (147006050..147022692, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene methylphosphate capping enzyme pseudogene Neighboring gene transmembrane protein 29 Neighboring gene zinc finger CCCH type containing 14 pseudogene Neighboring gene microRNA 3620 Neighboring gene Alas2R1 erythroid cis-regulatory module Neighboring gene aminolevulinic acid synthase 2, erythroid Neighboring gene Alas2R3 erythroid cis-regulatory module Neighboring gene 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 Neighboring gene trophinin Neighboring gene voltage-dependent anion channel 1 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-(apurinic or apyrimidinic site) endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables double-stranded DNA 3'-5' exodeoxyribonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables exonuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphoric diester hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA recombination IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in base-excision repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cellular response to DNA damage stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion HDA PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    DNA-(apurinic or apyrimidinic site) endonuclease 2
    Names
    AP endonuclease 2
    APEX nuclease 2
    DNA-(apurinic or apyrimidinic site) lyase 2
    NP_084219.1
    XP_006529054.1
    XP_011246181.1
    XP_030107378.1
    XP_036018008.1
    XP_036018009.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029943.2NP_084219.1  DNA-(apurinic or apyrimidinic site) endonuclease 2

      See identical proteins and their annotated locations for NP_084219.1

      Status: VALIDATED

      Source sequence(s)
      AB072498, CF426571
      Consensus CDS
      CCDS30463.1
      UniProtKB/Swiss-Prot
      Q68G58
      UniProtKB/TrEMBL
      A2AFM3
      Related
      ENSMUSP00000026303.10, ENSMUST00000026303.16
      Conserved Domains (2) summary
      cd09088
      Location:3310
      Ape2-like_AP-endo; Human Ape2-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases
      pfam06839
      Location:463512
      zf-GRF; GRF zinc finger

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      149286625..149371175 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030251518.2XP_030107378.1  DNA-(apurinic or apyrimidinic site) endonuclease 2 isoform X2

      Related
      ENSMUSP00000108345.2, ENSMUST00000112725.8
      Conserved Domains (1) summary
      cl00490
      Location:3222
      EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
    2. XM_036162115.1XP_036018008.1  DNA-(apurinic or apyrimidinic site) endonuclease 2 isoform X4

      Conserved Domains (1) summary
      cl00490
      Location:3223
      EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
    3. XM_036162116.1XP_036018009.1  DNA-(apurinic or apyrimidinic site) endonuclease 2 isoform X5

      Related
      ENSMUSP00000108339.2, ENSMUST00000112719.2
      Conserved Domains (1) summary
      cl00490
      Location:3213
      EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
    4. XM_011247879.4XP_011246181.1  DNA-(apurinic or apyrimidinic site) endonuclease 2 isoform X3

      Conserved Domains (1) summary
      cl00490
      Location:3223
      EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
    5. XM_006528991.4XP_006529054.1  DNA-(apurinic or apyrimidinic site) endonuclease 2 isoform X1

      Conserved Domains (2) summary
      cd09088
      Location:3320
      Ape2-like_AP-endo; Human Ape2-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases
      pfam06839
      Location:473522
      zf-GRF; GRF zinc finger

    RNA

    1. XR_878269.4 RNA Sequence

    2. XR_878270.4 RNA Sequence

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