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    Apex2 apurinic/apyrimidinic endonuclease 2 [ Mus musculus (house mouse) ]

    Gene ID: 77622, updated on 31-Jan-2019

    Summary

    Official Symbol
    Apex2provided by MGI
    Official Full Name
    apurinic/apyrimidinic endonuclease 2provided by MGI
    Primary source
    MGI:MGI:1924872
    See related
    Ensembl:ENSMUSG00000025269
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ape2; C430040P13Rik
    Expression
    Ubiquitous expression in liver E14.5 (RPKM 5.0), liver E14 (RPKM 4.2) and 28 other tissues See more
    Orthologs

    Genomic context

    See Apex2 in Genome Data Viewer
    Location:
    X; X F3
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) X NC_000086.7 (150503629..150588208, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (147006050..147022692, complement)

    Chromosome X - NC_000086.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 29 Neighboring gene zinc finger CCCH type containing 14 pseudogene Neighboring gene predicted gene, 46684 Neighboring gene microRNA 3620 Neighboring gene aminolevulinic acid synthase 2, erythroid Neighboring gene 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 Neighboring gene trophinin

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    • BER complex, organism-specific biosystem (from KEGG)
      BER complex, organism-specific biosystemStructural complex; Genetic information processing; Repair system
    • BER complex, conserved biosystem (from KEGG)
      BER complex, conserved biosystemStructural complex; Genetic information processing; Repair system
    • Base excision repair, organism-specific biosystem (from KEGG)
      Base excision repair, organism-specific biosystemBase excision repair (BER) is the predominant DNA damage repair pathway for the processing of small base lesions, derived from oxidation and alkylation damages. BER is normally defined as DNA repair ...
    • Base excision repair, conserved biosystem (from KEGG)
      Base excision repair, conserved biosystemBase excision repair (BER) is the predominant DNA damage repair pathway for the processing of small base lesions, derived from oxidation and alkylation damages. BER is normally defined as DNA repair ...

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    DNA-(apurinic or apyrimidinic site) endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    double-stranded DNA 3'-5' exodeoxyribonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    exonuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    lyase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    phosphodiesterase I activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    DNA recombination IEA
    Inferred from Electronic Annotation
    more info
     
    DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    base-excision repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to DNA damage stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    fibrillar center ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion HDA PubMed 
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    DNA-(apurinic or apyrimidinic site) lyase 2
    Names
    AP endonuclease 2
    APEX nuclease 2
    NP_084219.1
    XP_006529054.1
    XP_011246179.1
    XP_011246180.1
    XP_011246181.1
    XP_011246182.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029943.2NP_084219.1  DNA-(apurinic or apyrimidinic site) lyase 2

      See identical proteins and their annotated locations for NP_084219.1

      Status: VALIDATED

      Source sequence(s)
      AB072498, CF426571
      Consensus CDS
      CCDS30463.1
      UniProtKB/Swiss-Prot
      Q68G58
      UniProtKB/TrEMBL
      A2AFM3
      Related
      ENSMUSP00000026303.9, ENSMUST00000026303.15
      Conserved Domains (2) summary
      cd09088
      Location:3310
      Ape2-like_AP-endo; Human Ape2-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases
      pfam06839
      Location:463512
      zf-GRF; GRF zinc finger

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000086.7 Reference GRCm38.p4 C57BL/6J

      Range
      150503629..150588208 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011247877.2XP_011246179.1  DNA-(apurinic or apyrimidinic site) lyase 2 isoform X2

      Related
      ENSMUSP00000108347.3, ENSMUST00000112727.9
      Conserved Domains (1) summary
      cl00490
      Location:3222
      EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
    2. XM_011247878.2XP_011246180.1  DNA-(apurinic or apyrimidinic site) lyase 2 isoform X3

      See identical proteins and their annotated locations for XP_011246180.1

      UniProtKB/Swiss-Prot
      Q68G58
      Related
      ENSMUSP00000108345.1, ENSMUST00000112725.7
      Conserved Domains (1) summary
      cl00490
      Location:3212
      EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
    3. XM_011247880.2XP_011246182.1  DNA-(apurinic or apyrimidinic site) lyase 2 isoform X5

      Conserved Domains (1) summary
      cl00490
      Location:3223
      EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
    4. XM_011247879.2XP_011246181.1  DNA-(apurinic or apyrimidinic site) lyase 2 isoform X4

      Conserved Domains (1) summary
      cl00490
      Location:3223
      EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
    5. XM_006528991.3XP_006529054.1  DNA-(apurinic or apyrimidinic site) lyase 2 isoform X1

      Conserved Domains (2) summary
      cd09088
      Location:3320
      Ape2-like_AP-endo; Human Ape2-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases
      pfam06839
      Location:473522
      zf-GRF; GRF zinc finger

    RNA

    1. XR_878269.2 RNA Sequence

    2. XR_878266.2 RNA Sequence

    3. XR_878268.2 RNA Sequence

    4. XR_878267.2 RNA Sequence

    5. XR_878263.2 RNA Sequence

    6. XR_878271.2 RNA Sequence

    7. XR_001782760.1 RNA Sequence

    8. XR_878265.2 RNA Sequence

    9. XR_878264.2 RNA Sequence

    10. XR_878270.2 RNA Sequence

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