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    H2az2 H2A.Z histone variant 2 [ Mus musculus (house mouse) ]

    Gene ID: 77605, updated on 21-Sep-2021

    Summary

    Official Symbol
    H2az2provided by MGI
    Official Full Name
    H2A.Z histone variant 2provided by MGI
    Primary source
    MGI:MGI:1924855
    See related
    Ensembl:ENSMUSG00000041126
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    H2a; H2av; H2A.Z; H2afv; H2A.Z2; H2a.z-2; Wnt1cre; Wnt1-Cre; Wnt1::Cre; C530002L11Rik; Tg(Wnt1-cre)11Rth
    Summary
    Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent histone that is a member of the histone H2A family. [provided by RefSeq, Nov 2015]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 129.3), CNS E14 (RPKM 78.5) and 27 other tissues See more
    Orthologs
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    Genomic context

    See H2az2 in Genome Data Viewer
    Location:
    11; 11 A1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (6377226..6394511, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (6427226..6444511, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (6327229..6344446, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene zinc finger, MIZ-type containing 2 Neighboring gene microRNA 7651 Neighboring gene peptidylprolyl isomerase A Neighboring gene 60S ribosomal protein L36a-like Neighboring gene predicted gene 11971

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    part_of nucleosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    histone H2A.V
    Names
    H2A histone family, member V
    H2A.Z variant histone 2
    histone H2A.F/Z

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347064.1NP_001333993.1  histone H2A.V isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. It encodes isoform 2, which lacks an internal in-frame segment and is shorter, compared to isoform 1.
      Source sequence(s)
      AI851486, AL646020, BC028539, CJ069840
      Consensus CDS
      CCDS83779.1
      UniProtKB/TrEMBL
      Q8R029
      Related
      ENSMUSP00000091037.6, ENSMUST00000093346.6
      Conserved Domains (1) summary
      PTZ00017
      Location:390
      PTZ00017; histone H2A; Provisional
    2. NM_029938.1NP_084214.1  histone H2A.V isoform 1

      See identical proteins and their annotated locations for NP_084214.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AL646020, BC147294, CJ069840
      Consensus CDS
      CCDS48750.1
      UniProtKB/Swiss-Prot
      Q3THW5
      UniProtKB/TrEMBL
      B2RVP5
      Related
      ENSMUSP00000105359.3, ENSMUST00000109737.9
      Conserved Domains (1) summary
      PLN00154
      Location:6121
      PLN00154; histone H2A; Provisional

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      6377226..6394511 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030246426.2XP_030102286.1  histone H2A.V isoform X1

      Conserved Domains (1) summary
      PLN00154
      Location:30124
      PLN00154; histone H2A; Provisional
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