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    Nkrf NF-kappaB repressing factor [ Mus musculus (house mouse) ]

    Gene ID: 77286, updated on 31-Jan-2019

    Summary

    Official Symbol
    Nkrfprovided by MGI
    Official Full Name
    NF-kappaB repressing factorprovided by MGI
    Primary source
    MGI:MGI:1924536
    See related
    Ensembl:ENSMUSG00000044149
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C80287; AW124770; 9430034D17Rik
    Expression
    Broad expression in cerebellum adult (RPKM 4.4), frontal lobe adult (RPKM 3.5) and 22 other tissues See more
    Orthologs

    Genomic context

    See Nkrf in Genome Data Viewer
    Location:
    X; X A3.3
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) X NC_000086.7 (36886440..36903344, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (34427535..34442894, complement)

    Chromosome X - NC_000086.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA C330007P06 gene Neighboring gene 60S ribosomal protein L39 pseudogene Neighboring gene ubiquitin-conjugating enzyme E2A Neighboring gene predicted gene 15008 Neighboring gene septin 6 Neighboring gene sosondowah ankyrin repeat domain family member D

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
     
    RNA polymerase II proximal promoter sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    RNA polymerase II proximal promoter sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    negative regulation of transcription, DNA-templated IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    NF-kappa-B-repressing factor
    Names
    NFkB-repressing factor
    transcription factor NRF

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029891.2NP_084167.2  NF-kappa-B-repressing factor

      See identical proteins and their annotated locations for NP_084167.2

      Status: VALIDATED

      Source sequence(s)
      AK042690, BC095972, BM570357
      Consensus CDS
      CCDS30065.1
      UniProtKB/Swiss-Prot
      Q8BY02
      Related
      ENSMUSP00000061546.6, ENSMUST00000057093.6
      Conserved Domains (3) summary
      cd02640
      Location:603662
      R3H_NRF; R3H domain of the NF-kappaB-repression factor (NRF). NRF is a nuclear inhibitor of NF-kappaB proteins that can silence the IFNbeta promoter via binding to a negative regulatory element (NRE). Beside R3H NRF also contains a G-patch domain. The name of the ...
      smart00358
      Location:451512
      DSRM; Double-stranded RNA binding motif
      cl02611
      Location:549592
      G-patch; G-patch domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000086.7 Reference GRCm38.p4 C57BL/6J

      Range
      36886440..36903344 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006541409.3XP_006541472.1  NF-kappa-B-repressing factor isoform X1

      Conserved Domains (5) summary
      cd02640
      Location:697756
      R3H_NRF; R3H domain of the NF-kappaB-repression factor (NRF). NRF is a nuclear inhibitor of NF-kappaB proteins that can silence the IFNbeta promoter via binding to a negative regulatory element (NRE). Beside R3H NRF also contains a G-patch domain. The name of the ...
      smart00358
      Location:545606
      DSRM; Double-stranded RNA binding motif
      pfam00035
      Location:443503
      dsrm; Double-stranded RNA binding motif
      pfam11952
      Location:38105
      XTBD; XRN-Two Binding Domain, XTBD
      cl02611
      Location:643686
      G-patch; G-patch domain
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