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    Klhl2 kelch-like 2, Mayven [ Mus musculus (house mouse) ]

    Gene ID: 77113, updated on 31-Jan-2019

    Summary

    Official Symbol
    Klhl2provided by MGI
    Official Full Name
    kelch-like 2, Mayvenprovided by MGI
    Primary source
    MGI:MGI:1924363
    See related
    Ensembl:ENSMUSG00000031605
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mav; AU020744; ABP-KELCH; 6030411N21Rik; 8530402H02Rik
    Annotation information
    Annotation category: suggests misassembly
    Expression
    Broad expression in cortex adult (RPKM 26.9), frontal lobe adult (RPKM 22.8) and 27 other tissues See more
    Orthologs

    Genomic context

    See Klhl2 in Genome Data Viewer
    Location:
    8; 8 B3.1
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 8 NC_000074.6 (64739673..64850029, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (67335578..67373716, complement)

    Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene carboxypeptidase E Neighboring gene methylsterol monoxygenase 1 Neighboring gene predicted gene, 46040 Neighboring gene predicted gene, 40501 Neighboring gene predicted gene 45405

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA4249

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    actin binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Process Evidence Code Pubs
    protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    Cul3-RING ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    stress fiber ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_178633.3NP_848748.2  kelch-like protein 2

      See identical proteins and their annotated locations for NP_848748.2

      Status: VALIDATED

      Source sequence(s)
      AC140351, AC152168, AC242529
      Consensus CDS
      CCDS85544.1
      UniProtKB/Swiss-Prot
      Q8JZP3
      Related
      ENSMUSP00000034017.7, ENSMUST00000034017.8
      Conserved Domains (2) summary
      sd00038
      Location:486530
      Kelch; KELCH repeat [structural motif]
      cl28614
      Location:56573
      BTB; Broad-Complex, Tramtrack and Bric a brac

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000074.6 Reference GRCm38.p4 C57BL/6J

      Range
      64739673..64850029 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017313011.1XP_017168500.1  kelch-like protein 2 isoform X1

    2. XM_017313012.1XP_017168501.1  kelch-like protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A1B0GQV2
      Related
      ENSMUSP00000147262.1, ENSMUST00000210166.1
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