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    Klhl2 kelch-like 2, Mayven [ Mus musculus (house mouse) ]

    Gene ID: 77113, updated on 23-Jun-2021

    Summary

    Official Symbol
    Klhl2provided by MGI
    Official Full Name
    kelch-like 2, Mayvenprovided by MGI
    Primary source
    MGI:MGI:1924363
    See related
    Ensembl:ENSMUSG00000031605
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    M; Mav; ABP-KE; AU020744; ABP-KELCH; 6030411N21Rik; 8530402H02Rik
    Expression
    Broad expression in cortex adult (RPKM 26.9), frontal lobe adult (RPKM 22.8) and 27 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Klhl2 in Genome Data Viewer
    Location:
    8; 8 B3.1
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (65192707..65302821, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (64739673..64850169, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (67335578..67373716, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene carboxypeptidase E Neighboring gene methylsterol monoxygenase 1 Neighboring gene predicted gene, 46040 Neighboring gene predicted gene, 53437 Neighboring gene predicted gene, 40501 Neighboring gene predicted gene 45405

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA4249

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of Cul3-RING ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in stress fiber ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_178633.3NP_848748.2  kelch-like protein 2

      See identical proteins and their annotated locations for NP_848748.2

      Status: VALIDATED

      Source sequence(s)
      AC140351, AC152168, AC242529
      Consensus CDS
      CCDS85544.1
      UniProtKB/Swiss-Prot
      Q8JZP3
      Related
      ENSMUSP00000034017.8, ENSMUST00000034017.9
      Conserved Domains (2) summary
      sd00038
      Location:486530
      Kelch; KELCH repeat [structural motif]
      cl28614
      Location:56573
      BTB; Broad-Complex, Tramtrack and Bric a brac

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      65192707..65302821 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017313011.1XP_017168500.1  kelch-like protein 2 isoform X1

      Conserved Domains (4) summary
      PHA03098
      Location:56606
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:519563
      Kelch; KELCH repeat [structural motif]
      cd18512
      Location:186315
      BACK_KLHL2_Mayven; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2)
      cl38908
      Location:35188
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
    2. XM_036154378.1XP_036010271.1  kelch-like protein 2 isoform X3

      Conserved Domains (4) summary
      PHA03098
      Location:18568
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:481525
      Kelch; KELCH repeat [structural motif]
      cd18512
      Location:148277
      BACK_KLHL2_Mayven; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2)
      cl38908
      Location:1150
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
    3. XM_036154379.1XP_036010272.1  kelch-like protein 2 isoform X4

      Conserved Domains (4) summary
      PHA03098
      Location:18535
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:448492
      Kelch; KELCH repeat [structural motif]
      cd18512
      Location:115244
      BACK_KLHL2_Mayven; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2)
      cl38908
      Location:1117
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
    4. XM_017313012.3XP_017168501.1  kelch-like protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A1B0GQV2
      Related
      ENSMUSP00000147262.2, ENSMUST00000210166.2
      Conserved Domains (4) summary
      PHA03098
      Location:56573
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:486530
      Kelch; KELCH repeat [structural motif]
      cd18338
      Location:35155
      BTB_POZ_KLHL2_Mayven; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 2 (KLHL2)
      cd18512
      Location:153282
      BACK_KLHL2_Mayven; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2)
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