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    Nt5c2 5'-nucleotidase, cytosolic II [ Mus musculus (house mouse) ]

    Gene ID: 76952, updated on 5-Aug-2018

    Summary

    Official Symbol
    Nt5c2provided by MGI
    Official Full Name
    5'-nucleotidase, cytosolic IIprovided by MGI
    Primary source
    MGI:MGI:2178563
    See related
    Ensembl:ENSMUSG00000025041 Vega:OTTMUSG00000037178
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gmp; CnII; Nt5b; Pnt5; cN-II; Gm9751; 2010002I23Rik
    Expression
    Ubiquitous expression in whole brain E14.5 (RPKM 17.2), CNS E14 (RPKM 14.7) and 28 other tissues See more
    Orthologs

    Genomic context

    See Nt5c2 in Genome Data Viewer
    Location:
    19; 19 C3
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 19 NC_000085.6 (46885390..47015189, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (46961321..47089679, complement)

    Chromosome 19 - NC_000085.6Genomic Context describing neighboring genes Neighboring gene arsenic (+3 oxidation state) methyltransferase Neighboring gene cyclin M2 Neighboring gene DBF4 homolog pseudogene Neighboring gene lysophosphatidic acid receptor 1 pseudogene Neighboring gene internexin neuronal intermediate filament protein, alpha Neighboring gene polycomb group ring finger 6 Neighboring gene TATA-box binding protein associated factor 5 Neighboring gene upregulated during skeletal muscle growth 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    5'-nucleotidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    5'-nucleotidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    IMP metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    IMP metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    adenosine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    adenosine metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cellular_component ND
    No biological Data available
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    cytosolic purine 5'-nucleotidase
    Names
    cytosolic 5'-nucleotidase II
    NP_001157835.1
    NP_001157837.1
    NP_084086.3
    XP_006527521.1
    XP_006527522.1
    XP_011245700.1
    XP_017173798.1
    XP_017173799.1
    XP_017173800.1
    XP_017173801.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164363.1NP_001157835.1  cytosolic purine 5'-nucleotidase isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK008045, AK132384, CJ092327
      Consensus CDS
      CCDS50462.1
      UniProtKB/Swiss-Prot
      Q3V1L4
      UniProtKB/TrEMBL
      E9Q9M1
      Related
      ENSMUSP00000130898.2, OTTMUSP00000053468, ENSMUST00000172239.2, OTTMUST00000095787
      Conserved Domains (1) summary
      pfam05761
      Location:69514
      5_nucleotid; 5' nucleotidase family
    2. NM_001164365.1NP_001157837.1  cytosolic purine 5'-nucleotidase isoform 2

      See identical proteins and their annotated locations for NP_001157837.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC108814, AK008045, AK132384
      Consensus CDS
      CCDS50461.1
      UniProtKB/Swiss-Prot
      Q3V1L4
      UniProtKB/TrEMBL
      G3X9J6
      Related
      ENSMUSP00000084180.7, ENSMUST00000086961.13
      Conserved Domains (1) summary
      pfam05761
      Location:68513
      5_nucleotid; 5' nucleotidase family
    3. NM_029810.4NP_084086.3  cytosolic purine 5'-nucleotidase isoform 3

      See identical proteins and their annotated locations for NP_084086.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
      Source sequence(s)
      AC108814, AK008045, AK132384, CJ139558
      Consensus CDS
      CCDS29883.1
      UniProtKB/Swiss-Prot
      Q3V1L4
      Related
      ENSMUSP00000129126.1, ENSMUST00000168536.7
      Conserved Domains (1) summary
      pfam05761
      Location:43488
      5_nucleotid; 5' nucleotidase family

    RNA

    1. NR_028353.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) has multiple differences, compared to variant 1. This variant is represented as non-coding because the use of one of the supported translational start codons, as used in variant 3, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC108814, AK008045, AK030786, AK132384, CJ139558

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000085.6 Reference GRCm38.p4 C57BL/6J

      Range
      46885390..47015189 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006527459.2XP_006527522.1  cytosolic purine 5'-nucleotidase isoform X1

      See identical proteins and their annotated locations for XP_006527522.1

      UniProtKB/Swiss-Prot
      Q3V1L4
      Conserved Domains (1) summary
      pfam05761
      Location:43488
      5_nucleotid; 5' nucleotidase family
    2. XM_011247398.2XP_011245700.1  cytosolic purine 5'-nucleotidase isoform X2

      Conserved Domains (1) summary
      pfam05761
      Location:55357
      5_nucleotid; 5' nucleotidase family
    3. XM_017318310.1XP_017173799.1  cytosolic purine 5'-nucleotidase isoform X3

      Conserved Domains (1) summary
      cl17687
      Location:1297
      5_nucleotid; 5' nucleotidase family
    4. XM_017318309.1XP_017173798.1  cytosolic purine 5'-nucleotidase isoform X2

      Conserved Domains (1) summary
      pfam05761
      Location:55357
      5_nucleotid; 5' nucleotidase family
    5. XM_017318311.1XP_017173800.1  cytosolic purine 5'-nucleotidase isoform X3

      Conserved Domains (1) summary
      cl17687
      Location:1297
      5_nucleotid; 5' nucleotidase family
    6. XM_006527458.2XP_006527521.1  cytosolic purine 5'-nucleotidase isoform X1

      See identical proteins and their annotated locations for XP_006527521.1

      UniProtKB/Swiss-Prot
      Q3V1L4
      Conserved Domains (1) summary
      pfam05761
      Location:43488
      5_nucleotid; 5' nucleotidase family
    7. XM_017318312.1XP_017173801.1  cytosolic purine 5'-nucleotidase isoform X3

      Conserved Domains (1) summary
      cl17687
      Location:1297
      5_nucleotid; 5' nucleotidase family
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