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    Nt5c2 5'-nucleotidase, cytosolic II [ Mus musculus (house mouse) ]

    Gene ID: 76952, updated on 5-Sep-2021

    Summary

    Official Symbol
    Nt5c2provided by MGI
    Official Full Name
    5'-nucleotidase, cytosolic IIprovided by MGI
    Primary source
    MGI:MGI:2178563
    See related
    Ensembl:ENSMUSG00000025041
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PN; cN; Gmp; NT5; CnII; Nt5b; Pnt5; cN-II; Gm9751; 2010002I23Rik
    Expression
    Ubiquitous expression in whole brain E14.5 (RPKM 17.2), CNS E14 (RPKM 14.7) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Nt5c2 in Genome Data Viewer
    Location:
    19; 19 C3
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (46873829..47003613, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (46885390..47015174, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (46961321..47089679, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene arsenite methyltransferase Neighboring gene cyclin M2 Neighboring gene DBF4 homolog pseudogene Neighboring gene lysophosphatidic acid receptor 1 pseudogene Neighboring gene internexin neuronal intermediate filament protein, alpha Neighboring gene polycomb group ring finger 6 Neighboring gene predicted gene, 23140

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 5'-nucleotidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables 5'-nucleotidase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables GMP 5'-nucleotidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables GMP 5'-nucleotidase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables IMP 5'-nucleotidase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in GMP catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in GMP catabolic process to guanine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in IMP catabolic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in IMP metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in IMP metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in adenosine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in adenosine metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in allantoin metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in allantoin metabolic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in dGMP catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within nucleotide metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    cytosolic purine 5'-nucleotidase
    Names
    cytosolic 5'-nucleotidase II
    NP_001157835.1
    NP_001157837.1
    NP_001363995.1
    NP_001363997.1
    NP_001363998.1
    NP_001363999.1
    NP_084086.3
    XP_030106990.1
    XP_030106991.1
    XP_030106997.1
    XP_030107000.1
    XP_036017617.1
    XP_036017618.1
    XP_036017619.1
    XP_036017620.1
    XP_036017621.1
    XP_036017622.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164363.2NP_001157835.1  cytosolic purine 5'-nucleotidase isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC108814, AC122442
      Consensus CDS
      CCDS50462.1
      UniProtKB/Swiss-Prot
      Q3V1L4
      UniProtKB/TrEMBL
      E9Q9M1
      Related
      ENSMUSP00000130898.3, ENSMUST00000172239.3
      Conserved Domains (1) summary
      pfam05761
      Location:69514
      5_nucleotid; 5' nucleotidase family
    2. NM_001164365.2NP_001157837.1  cytosolic purine 5'-nucleotidase isoform 2

      See identical proteins and their annotated locations for NP_001157837.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC108814, AC122442
      Consensus CDS
      CCDS50461.1
      UniProtKB/Swiss-Prot
      Q3V1L4
      UniProtKB/TrEMBL
      G3X9J6
      Related
      ENSMUSP00000157802.2, ENSMUST00000235234.2
      Conserved Domains (1) summary
      pfam05761
      Location:68513
      5_nucleotid; 5' nucleotidase family
    3. NM_001377066.1NP_001363995.1  cytosolic purine 5'-nucleotidase isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5), as well as variants 3, 6, and 7, encodes isoform 3.
      Source sequence(s)
      AC108814, AC122442
      Conserved Domains (1) summary
      pfam05761
      Location:43488
      5_nucleotid; 5' nucleotidase family
    4. NM_001377068.1NP_001363997.1  cytosolic purine 5'-nucleotidase isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6), as well as variants 3, 5, and 7, encodes isoform 3.
      Source sequence(s)
      AC108814, AC122442
      Conserved Domains (1) summary
      pfam05761
      Location:43488
      5_nucleotid; 5' nucleotidase family
    5. NM_001377069.1NP_001363998.1  cytosolic purine 5'-nucleotidase isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7), as well as variants 3, 5, and 6, encodes isoform 3.
      Source sequence(s)
      AC108814, AC122442
      Related
      ENSMUSP00000158280.2, ENSMUST00000236501.2
      Conserved Domains (1) summary
      pfam05761
      Location:43488
      5_nucleotid; 5' nucleotidase family
    6. NM_001377070.1NP_001363999.1  cytosolic purine 5'-nucleotidase isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC108814, AC122442
      Related
      ENSMUSP00000158576.2, ENSMUST00000236727.2
      Conserved Domains (1) summary
      pfam05761
      Location:14459
      5_nucleotid; 5' nucleotidase family
    7. NM_029810.5NP_084086.3  cytosolic purine 5'-nucleotidase isoform 3

      See identical proteins and their annotated locations for NP_084086.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (3) is shorter than isoform 1. Variants 3 and 5-7 all encode the same isoform (3).
      Source sequence(s)
      AC108814, AC122442
      Consensus CDS
      CCDS29883.1
      UniProtKB/Swiss-Prot
      Q3V1L4
      Related
      ENSMUSP00000129126.2, ENSMUST00000168536.9
      Conserved Domains (1) summary
      pfam05761
      Location:43488
      5_nucleotid; 5' nucleotidase family

    RNA

    1. NR_028353.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC108814, AC122442
    2. NR_165058.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC108814, AC122442
    3. NR_165059.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC108814, AC122442
    4. NR_165060.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC108814, AC122442
    5. NR_165061.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC108814, AC122442
    6. NR_165062.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC108814, AC122442
    7. NR_165063.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC108814, AC122442
    8. NR_165064.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC108814, AC122442
    9. NR_165065.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC108814, AC122442
    10. NR_165066.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC108814, AC122442
    11. NR_165067.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC108814, AC122442
    12. NR_165068.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC108814, AC122442
    13. NR_165069.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC108814, AC122442
    14. NR_165070.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC108814, AC122442
    15. NR_165071.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC108814, AC122442
    16. NR_165072.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC108814, AC122442
    17. NR_165073.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC108814, AC122442
    18. NR_165074.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC108814, AC122442
    19. NR_165075.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC108814, AC122442
    20. NR_165076.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC108814, AC122442
    21. NR_165253.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC108814, AC122442
      Related
      ENSMUST00000086961.15

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      46873829..47003613 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036161729.1XP_036017622.1  cytosolic purine 5'-nucleotidase isoform X3

      Conserved Domains (1) summary
      cl17687
      Location:1297
      5_nucleotid; 5' nucleotidase family
    2. XM_030251137.1XP_030106997.1  cytosolic purine 5'-nucleotidase isoform X3

      Conserved Domains (1) summary
      cl17687
      Location:1297
      5_nucleotid; 5' nucleotidase family
    3. XM_036161725.1XP_036017618.1  cytosolic purine 5'-nucleotidase isoform X2

      Conserved Domains (1) summary
      pfam05761
      Location:55357
      5_nucleotid; 5' nucleotidase family
    4. XM_036161727.1XP_036017620.1  cytosolic purine 5'-nucleotidase isoform X2

      Conserved Domains (1) summary
      pfam05761
      Location:55357
      5_nucleotid; 5' nucleotidase family
    5. XM_030251130.2XP_030106990.1  cytosolic purine 5'-nucleotidase isoform X2

      Conserved Domains (1) summary
      pfam05761
      Location:55357
      5_nucleotid; 5' nucleotidase family
    6. XM_030251140.2XP_030107000.1  cytosolic purine 5'-nucleotidase isoform X3

      Conserved Domains (1) summary
      cl17687
      Location:1297
      5_nucleotid; 5' nucleotidase family
    7. XM_036161724.1XP_036017617.1  cytosolic purine 5'-nucleotidase isoform X1

      Conserved Domains (1) summary
      pfam05761
      Location:43488
      5_nucleotid; 5' nucleotidase family
    8. XM_030251131.1XP_030106991.1  cytosolic purine 5'-nucleotidase isoform X2

      Conserved Domains (1) summary
      pfam05761
      Location:55357
      5_nucleotid; 5' nucleotidase family
    9. XM_036161728.1XP_036017621.1  cytosolic purine 5'-nucleotidase isoform X3

      Conserved Domains (1) summary
      cl17687
      Location:1297
      5_nucleotid; 5' nucleotidase family
    10. XM_036161726.1XP_036017619.1  cytosolic purine 5'-nucleotidase isoform X2

      Conserved Domains (1) summary
      pfam05761
      Location:55357
      5_nucleotid; 5' nucleotidase family
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