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    Jade2 jade family PHD finger 2 [ Mus musculus (house mouse) ]

    Gene ID: 76901, updated on 23-Jun-2021

    Summary

    Official Symbol
    Jade2provided by MGI
    Official Full Name
    jade family PHD finger 2provided by MGI
    Primary source
    MGI:MGI:1924151
    See related
    Ensembl:ENSMUSG00000020387
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Phf1; Phf15; AI480685; mKIAA0239; 1200017K05Rik
    Expression
    Broad expression in thymus adult (RPKM 14.2), lung adult (RPKM 11.2) and 20 other tissues See more
    Orthologs
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    Genomic context

    See Jade2 in Genome Data Viewer
    Location:
    11; 11 B1.3
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (51704275..51749835, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (51813448..51859011, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (51626958..51670983, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene Sec24 related gene family, member A (S. cerevisiae) Neighboring gene predicted gene, 25291 Neighboring gene secretion associated Ras related GTPase 1B Neighboring gene predicted gene, 30110 Neighboring gene predicted gene, 39820 Neighboring gene predicted gene, 39821

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within SMAD protein signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in histone H3 acetylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in histone H3 acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in histone H4-K12 acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in histone H4-K5 acetylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in histone H4-K5 acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in histone H4-K8 acetylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in histone H4-K8 acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within neuron projection extension IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of neurogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of neurogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within protein autoubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within protein polyubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within protein polyubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of neurogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of histone acetyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of histone acetyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase Jade-2
    Names
    PHD finger protein 15
    jade family PHD finger protein 2
    protein Jade-2
    NP_001344517.1
    NP_955003.2
    XP_006534531.1
    XP_006534532.1
    XP_006534533.1
    XP_011247611.1
    XP_036012980.1
    XP_036012981.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357588.2NP_001344517.1  E3 ubiquitin-protein ligase Jade-2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AK147453, BP759644, BY283066, CJ112213
      Conserved Domains (3) summary
      cd15705
      Location:326436
      ePHD_JADE2; Extended PHD finger found in protein Jade-2 and similar proteins
      cl26464
      Location:676852
      Atrophin-1; Atrophin-1 family
      cl26518
      Location:209578
      EPL1; Enhancer of polycomb-like
    2. NM_199299.4NP_955003.2  E3 ubiquitin-protein ligase Jade-2 isoform 2

      See identical proteins and their annotated locations for NP_955003.2

      Status: VALIDATED

      Source sequence(s)
      AL645602, AL669920
      Consensus CDS
      CCDS24662.1
      UniProtKB/Swiss-Prot
      Q6ZQF7
      Related
      ENSMUSP00000020655.8, ENSMUST00000020655.14
      Conserved Domains (3) summary
      PHA03247
      Location:604780
      PHA03247; large tegument protein UL36; Provisional
      COG5141
      Location:137506
      COG5141; PHD zinc finger-containing protein [General function prediction only]
      cd15705
      Location:254364
      ePHD_JADE2; Extended PHD finger found in protein Jade-2 and similar proteins

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      51704275..51749835 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006534470.5XP_006534533.1  E3 ubiquitin-protein ligase Jade-2 isoform X2

      See identical proteins and their annotated locations for XP_006534533.1

      UniProtKB/Swiss-Prot
      Q6ZQF7
      Conserved Domains (3) summary
      PHA03247
      Location:604780
      PHA03247; large tegument protein UL36; Provisional
      COG5141
      Location:137506
      COG5141; PHD zinc finger-containing protein [General function prediction only]
      cd15705
      Location:254364
      ePHD_JADE2; Extended PHD finger found in protein Jade-2 and similar proteins
    2. XM_011249309.3XP_011247611.1  E3 ubiquitin-protein ligase Jade-2 isoform X2

      See identical proteins and their annotated locations for XP_011247611.1

      UniProtKB/Swiss-Prot
      Q6ZQF7
      Conserved Domains (3) summary
      PHA03247
      Location:604780
      PHA03247; large tegument protein UL36; Provisional
      COG5141
      Location:137506
      COG5141; PHD zinc finger-containing protein [General function prediction only]
      cd15705
      Location:254364
      ePHD_JADE2; Extended PHD finger found in protein Jade-2 and similar proteins
    3. XM_036157088.1XP_036012981.1  E3 ubiquitin-protein ligase Jade-2 isoform X2

      Conserved Domains (3) summary
      PHA03247
      Location:604780
      PHA03247; large tegument protein UL36; Provisional
      COG5141
      Location:137506
      COG5141; PHD zinc finger-containing protein [General function prediction only]
      cd15705
      Location:254364
      ePHD_JADE2; Extended PHD finger found in protein Jade-2 and similar proteins
    4. XM_006534469.5XP_006534532.1  E3 ubiquitin-protein ligase Jade-2 isoform X2

      See identical proteins and their annotated locations for XP_006534532.1

      UniProtKB/Swiss-Prot
      Q6ZQF7
      Conserved Domains (3) summary
      PHA03247
      Location:604780
      PHA03247; large tegument protein UL36; Provisional
      COG5141
      Location:137506
      COG5141; PHD zinc finger-containing protein [General function prediction only]
      cd15705
      Location:254364
      ePHD_JADE2; Extended PHD finger found in protein Jade-2 and similar proteins
    5. XM_006534468.5XP_006534531.1  E3 ubiquitin-protein ligase Jade-2 isoform X1

      Conserved Domains (3) summary
      PHA03247
      Location:640816
      PHA03247; large tegument protein UL36; Provisional
      COG5141
      Location:173542
      COG5141; PHD zinc finger-containing protein [General function prediction only]
      cd15705
      Location:290400
      ePHD_JADE2; Extended PHD finger found in protein Jade-2 and similar proteins
    6. XM_036157087.1XP_036012980.1  E3 ubiquitin-protein ligase Jade-2 isoform X2

      Conserved Domains (3) summary
      PHA03247
      Location:604780
      PHA03247; large tegument protein UL36; Provisional
      COG5141
      Location:137506
      COG5141; PHD zinc finger-containing protein [General function prediction only]
      cd15705
      Location:254364
      ePHD_JADE2; Extended PHD finger found in protein Jade-2 and similar proteins
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