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    Bicd2 BICD cargo adaptor 2 [ Mus musculus (house mouse) ]

    Gene ID: 76895, updated on 31-Jan-2019

    Summary

    Official Symbol
    Bicd2provided by MGI
    Official Full Name
    BICD cargo adaptor 2provided by MGI
    Primary source
    MGI:MGI:1924145
    See related
    Ensembl:ENSMUSG00000037933
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Expression
    Ubiquitous expression in lung adult (RPKM 19.5), testis adult (RPKM 16.2) and 28 other tissues See more
    Orthologs

    Genomic context

    See Bicd2 in Genome Data Viewer
    Location:
    13; 13 A5
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 13 NC_000079.6 (49341549..49387026)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (49436918..49482394)

    Chromosome 13 - NC_000079.6Genomic Context describing neighboring genes Neighboring gene sushi domain containing 3 Neighboring gene FYVE, RhoGEF and PH domain containing 3 Neighboring gene predicted gene, 46413 Neighboring gene inositol 1,3,4,5,6-pentakisphosphate 2-kinase

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA0699, 0610027D24Rik, 1110005D12Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    Rab GTPase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    cytoskeletal adaptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    dynactin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dynein complex binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dynein light intermediate chain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    centrosome localization ISO
    Inferred from Sequence Orthology
    more info
     
    mRNA transport IEA
    Inferred from Electronic Annotation
    more info
     
    microtubule anchoring at microtubule organizing center IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    microtubule-based movement IDA
    Inferred from Direct Assay
    more info
    PubMed 
    minus-end-directed organelle transport along microtubule IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein localization to Golgi apparatus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein localization to Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of microtubule cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    retrograde vesicle-mediated transport, Golgi to ER IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    retrograde vesicle-mediated transport, Golgi to ER ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    annulate lamellae ISO
    Inferred from Sequence Orthology
    more info
     
    centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear pore ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    protein bicaudal D homolog 2
    Names
    bic-D 2
    bicaudal D homolog 2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039179.2NP_001034268.1  protein bicaudal D homolog 2 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK122348, BP775855, CF538535
      Consensus CDS
      CCDS36657.1
      UniProtKB/Swiss-Prot
      Q921C5
      Related
      ENSMUSP00000039394.6, ENSMUST00000048544.13
      Conserved Domains (3) summary
      pfam09730
      Location:83797
      BicD; Microtubule-associated protein Bicaudal-D
      cl19219
      Location:55169
      DUF342; Protein of unknown function (DUF342)
      cl19252
      Location:178230
      MreC; rod shape-determining protein MreC
    2. NM_001039180.2NP_001034269.1  protein bicaudal D homolog 2 isoform 3

      See identical proteins and their annotated locations for NP_001034269.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in both UTRs and the 3' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform is shorter, compared to isoform 1.
      Source sequence(s)
      AK122348, BP775855, CF538535
      Consensus CDS
      CCDS49261.1
      UniProtKB/Swiss-Prot
      Q921C5
      UniProtKB/TrEMBL
      D3Z390
      Related
      ENSMUSP00000105711.2, ENSMUST00000110084.3
      Conserved Domains (2) summary
      pfam09730
      Location:9723
      BicD; Microtubule-associated protein Bicaudal-D
      cl19252
      Location:104156
      MreC; rod shape-determining protein MreC
    3. NM_029791.4NP_084067.1  protein bicaudal D homolog 2 isoform 2

      See identical proteins and their annotated locations for NP_084067.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' coding sequence and 3' UTR, compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK122348, BP775855, CF538535
      Consensus CDS
      CCDS36656.1
      UniProtKB/Swiss-Prot
      Q921C5
      Related
      ENSMUSP00000105712.3, ENSMUST00000110085.10
      Conserved Domains (3) summary
      pfam09730
      Location:83797
      BicD; Microtubule-associated protein Bicaudal-D
      cl19219
      Location:55169
      DUF342; Protein of unknown function (DUF342)
      cl19252
      Location:178230
      MreC; rod shape-determining protein MreC

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000079.6 Reference GRCm38.p4 C57BL/6J

      Range
      49341549..49387026
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011244429.2XP_011242731.1  protein bicaudal D homolog 2 isoform X1

      Conserved Domains (1) summary
      pfam09730
      Location:23618
      BicD; Microtubule-associated protein Bicaudal-D
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