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    Coq8b coenzyme Q8B [ Mus musculus (house mouse) ]

    Gene ID: 76889, updated on 19-Mar-2019

    Summary

    Official Symbol
    Coq8bprovided by MGI
    Official Full Name
    coenzyme Q8Bprovided by MGI
    Primary source
    MGI:MGI:1924139
    See related
    Ensembl:ENSMUSG00000003762
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Adck4; 0610012P18Rik
    Expression
    Ubiquitous expression in adrenal adult (RPKM 18.8), ovary adult (RPKM 9.9) and 28 other tissues See more
    Orthologs

    Genomic context

    See Coq8b in Genome Data Viewer
    Location:
    7; 7 A3
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (27228607..27257949)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (28018032..28042968)

    Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene cDNA sequence BC024978 Neighboring gene microRNA 1191 Neighboring gene inositol 1,4,5-trisphosphate 3-kinase C Neighboring gene numb-like Neighboring gene ribosomal protein L14 pseudogene Neighboring gene latent transforming growth factor beta binding protein 4 Neighboring gene predicted gene, 30543

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    General gene information

    Markers

    Homology

    Clone Names

    • MGC101983, MGC102655

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cerebellar Purkinje cell layer morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquinone biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ubiquinone biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    extrinsic component of mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrion HDA PubMed 
    mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    atypical kinase COQ8B, mitochondrial; aarF domain-containing protein kinase 4
    Names
    aarF domain containing kinase 4
    coenzyme Q protein 8B

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133770.2NP_598531.2  atypical kinase COQ8B, mitochondrial

      See identical proteins and their annotated locations for NP_598531.2

      Status: VALIDATED

      Source sequence(s)
      AK002619, AK079366, AK137168, BB770607, BY202506
      Consensus CDS
      CCDS39847.1
      UniProtKB/TrEMBL
      E9QLB8
      Related
      ENSMUSP00000003860.6, ENSMUST00000003860.12
      Conserved Domains (2) summary
      COG0661
      Location:135513
      AarF; Predicted unusual protein kinase regulating ubiquinone biosynthesis, AarF/ABC1/UbiB family [Coenzyme transport and metabolism, Signal transduction mechanisms]
      cd13970
      Location:176425
      ABC1_ADCK3; Activator of bc1 complex (ABC1) kinases, also called aarF domain containing kinase 3

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000073.6 Reference GRCm38.p4 C57BL/6J

      Range
      27228607..27257949
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006540422.2XP_006540485.1  aarF domain-containing protein kinase 4 isoform X1

      See identical proteins and their annotated locations for XP_006540485.1

      UniProtKB/TrEMBL
      E9QLB8
      Conserved Domains (2) summary
      COG0661
      Location:135513
      AarF; Predicted unusual protein kinase regulating ubiquinone biosynthesis, AarF/ABC1/UbiB family [Coenzyme transport and metabolism, Signal transduction mechanisms]
      cd13970
      Location:176425
      ABC1_ADCK3; Activator of bc1 complex (ABC1) kinases, also called aarF domain containing kinase 3
    2. XM_011250741.2XP_011249043.1  aarF domain-containing protein kinase 4 isoform X4

      Related
      ENSMUSP00000123309.1, ENSMUST00000128090.7
      Conserved Domains (2) summary
      COG0661
      Location:135299
      AarF; Predicted unusual protein kinase regulating ubiquinone biosynthesis, AarF/ABC1/UbiB family [Coenzyme transport and metabolism, Signal transduction mechanisms]
      cl21453
      Location:176299
      PKc_like; Protein Kinases, catalytic domain
    3. XM_011250740.2XP_011249042.1  aarF domain-containing protein kinase 4 isoform X2

      Conserved Domains (2) summary
      COG0661
      Location:135378
      AarF; Predicted unusual protein kinase regulating ubiquinone biosynthesis, AarF/ABC1/UbiB family [Coenzyme transport and metabolism, Signal transduction mechanisms]
      cd13970
      Location:176382
      ABC1_ADCK3; Activator of bc1 complex (ABC1) kinases, also called aarF domain containing kinase 3
    4. XM_017312383.1XP_017167872.1  aarF domain-containing protein kinase 4 isoform X3

      Conserved Domains (2) summary
      COG0661
      Location:1354
      AarF; Predicted unusual protein kinase regulating ubiquinone biosynthesis, AarF/ABC1/UbiB family [Coenzyme transport and metabolism, Signal transduction mechanisms]
      cd13970
      Location:17266
      ABC1_ADCK3; Activator of bc1 complex (ABC1) kinases, also called aarF domain containing kinase 3
    5. XM_006540421.1XP_006540484.1  aarF domain-containing protein kinase 4 isoform X1

      See identical proteins and their annotated locations for XP_006540484.1

      UniProtKB/TrEMBL
      E9QLB8
      Related
      ENSMUSP00000104015.3, ENSMUST00000108378.9
      Conserved Domains (2) summary
      COG0661
      Location:135513
      AarF; Predicted unusual protein kinase regulating ubiquinone biosynthesis, AarF/ABC1/UbiB family [Coenzyme transport and metabolism, Signal transduction mechanisms]
      cd13970
      Location:176425
      ABC1_ADCK3; Activator of bc1 complex (ABC1) kinases, also called aarF domain containing kinase 3
    6. XM_017312382.1XP_017167871.1  aarF domain-containing protein kinase 4 isoform X3

      Conserved Domains (2) summary
      COG0661
      Location:1354
      AarF; Predicted unusual protein kinase regulating ubiquinone biosynthesis, AarF/ABC1/UbiB family [Coenzyme transport and metabolism, Signal transduction mechanisms]
      cd13970
      Location:17266
      ABC1_ADCK3; Activator of bc1 complex (ABC1) kinases, also called aarF domain containing kinase 3

    RNA

    1. XR_391109.2 RNA Sequence

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