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    Dcun1d5 DCN1, defective in cullin neddylation 1, domain containing 5 (S. cerevisiae) [ Mus musculus (house mouse) ]

    Gene ID: 76863, updated on 31-Jul-2021

    Summary

    Official Symbol
    Dcun1d5provided by MGI
    Official Full Name
    DCN1, defective in cullin neddylation 1, domain containing 5 (S. cerevisiae)provided by MGI
    Primary source
    MGI:MGI:1924113
    See related
    Ensembl:ENSMUSG00000032002
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DCNL5; AW060460; 3110001A18Rik; 4833420K19Rik; D430047L21Rik
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 25.2), adrenal adult (RPKM 24.2) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Dcun1d5 in Genome Data Viewer
    Location:
    9; 9 A1
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (7176590..7220880)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (7176590..7220880)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (7184566..7207031)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 23097 Neighboring gene predicted gene, 53497 Neighboring gene dynein cytoplasmic 2 heavy chain 1 Neighboring gene predicted gene, 31639 Neighboring gene matrix metallopeptidase 13

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cullin family protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables cullin family protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin conjugating enzyme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ubiquitin-like protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to DNA damage stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein neddylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of ubiquitin-protein transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein neddylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of protein neddylation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in spindle ISO
    Inferred from Sequence Orthology
    more info
     
    part_of ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    DCN1-like protein 5
    Names
    DCUN1 domain-containing protein 5
    defective in cullin neddylation protein 1-like protein 5
    squamous cell carcinoma-related oncogene 5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357483.1NP_001344412.1  DCN1-like protein 5 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC174457, AK012764, AK134862, CO801841
      Consensus CDS
      CCDS90493.1
      Related
      ENSMUSP00000034499.10, ENSMUST00000034499.10
      Conserved Domains (1) summary
      pfam03556
      Location:120185
      Cullin_binding; Cullin binding
    2. NM_001357484.1NP_001344413.1  DCN1-like protein 5 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence and contains an alternate exon in the 3' coding sequence compared to variant 1, that causes a frameshift. The resulting isoform (3) is shorter at the N-terminus and has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC155908, AC174457
      Conserved Domains (1) summary
      pfam03556
      Location:51161
      Cullin_binding; Cullin binding
    3. NM_029775.3NP_084051.1  DCN1-like protein 5 isoform 2

      See identical proteins and their annotated locations for NP_084051.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate exon in the 3' coding sequence compared to variant 1, that causes a frameshift. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC174457, AK134862, CO801841
      Consensus CDS
      CCDS40529.1
      UniProtKB/Swiss-Prot
      Q9CXV9
      Related
      ENSMUSP00000150564.2, ENSMUST00000215683.2
      Conserved Domains (1) summary
      pfam03556
      Location:120230
      Cullin_binding; Cullin binding

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      7176590..7220880
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006509889.5XP_006509952.1  DCN1-like protein 5 isoform X2

      Conserved Domains (1) summary
      pfam03556
      Location:120219
      Cullin_binding; Cullin binding
    2. XM_030244711.1XP_030100571.1  DCN1-like protein 5 isoform X1

      Conserved Domains (1) summary
      pfam03556
      Location:199309
      Cullin_binding; Cullin binding

    RNA

    1. XR_004935592.1 RNA Sequence

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