Nlrp14 NLR family, pyrin domain containing 14 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nlrp14provided by MGI
Official Full Name: NLR family, pyrin domain containing 14provided by MGI
Primary source: MGI:MGI:1924108
See related: Ensembl:ENSMUSG00000016626 AllianceGenome:MGI:1924108
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: GC-LRR; Nalp14; Nalp14l; Nalp-iota; 4921520L01Rik
Summary: Predicted to enable ATP binding activity. Predicted to be involved in spermatogenesis. Predicted to act upstream of or within cell differentiation. Predicted to be located in cytoplasm. Is expressed in oocyte; ovary; and uterus. Orthologous to human NLRP14 (NLR family pyrin domain containing 14). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward testis adult (RPKM 17.2) See more
Orthologs: human all
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Genomic context

Location:: 7; 7 E3

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (106712662..106797310)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (107113455..107198103)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Nalp14 transcripts were continuously expressed through the preovulatory stage, but declined when meiotic maturation resumed, and they were markedly diminished by the 2-cell embryo stage.
Title: The mouse germ-cell-specific leucine-rich repeat protein NALP14: a member of the NACHT nucleoside triphosphatase family.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Nlrp14 (e-PCR), detects polymorphism
- UniSTS:516673

Nlrp14 (e-PCR), detects polymorphism
- UniSTS:526824

Homology

Homologs of the Nlrp14 gene: The Nlrp14 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, and rat.
Orthologs from Annotation Pipeline: 179 organisms have orthologs with human gene Nlrp14
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables molecular_function	ND No biological Data available more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
involved_in regulation of inflammatory response	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in spermatogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info	PubMed

General protein information

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Preferred Names: NACHT, LRR and PYD domains-containing protein 14

Names: NACHT, leucine rich repeat and PYD containing 14; RNI-like protein; germ-cell specific leucine rich repeat NTPase

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001002894.2 → NP_001002894.2 NACHT, LRR and PYD domains-containing protein 14

See identical proteins and their annotated locations for NP_001002894.2

Status: VALIDATED

Source sequence(s)

BC141199, CJ053047, DV644607

Consensus CDS

CCDS21688.1

UniProtKB/Swiss-Prot

Q66X14, Q6B966

Related

ENSMUSP00000081819.3, ENSMUST00000084763.5

Conserved Domains (5) summary

sd00033
Location:637 → 660

LRR_RI; leucine-rich repeat [structural motif]

pfam05729
Location:82 → 249

NACHT; NACHT domain

pfam17776
Location:383 → 500

NLRC4_HD2; NLRC4 helical domain HD2

pfam17779
Location:326 → 381

NOD2_WH; NOD2 winged helix domain

cl39015
Location:635 → 952

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

106712662..106797310

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011241938.2 → XP_011240240.1 NACHT, LRR and PYD domains-containing protein 14 isoform X1

See identical proteins and their annotated locations for XP_011240240.1

UniProtKB/Swiss-Prot

Q66X14, Q6B966

Conserved Domains (5) summary

sd00033
Location:637 → 660

LRR_RI; leucine-rich repeat [structural motif]

pfam05729
Location:82 → 249

NACHT; NACHT domain

pfam17776
Location:383 → 500

NLRC4_HD2; NLRC4 helical domain HD2

pfam17779
Location:326 → 381

NOD2_WH; NOD2 winged helix domain

cl39015
Location:635 → 952

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...