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    Hyls1 HYLS1, centriolar and ciliogenesis associated [ Mus musculus (house mouse) ]

    Gene ID: 76832, updated on 26-Sep-2022

    Summary

    Official Symbol
    Hyls1provided by MGI
    Official Full Name
    HYLS1, centriolar and ciliogenesis associatedprovided by MGI
    Primary source
    MGI:MGI:1924082
    See related
    Ensembl:ENSMUSG00000050555 AllianceGenome:MGI:1924082
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    3010015K02Rik
    Summary
    Predicted to be involved in cilium assembly. Predicted to act upstream of or within cell projection organization. Predicted to be located in several cellular components, including centrosome; cytosol; and nucleus. Predicted to be active in centriole and non-motile cilium. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in hydrolethalus syndrome 1. Orthologous to human HYLS1 (HYLS1 centriolar and ciliogenesis associated). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in testis adult (RPKM 18.2), CNS E11.5 (RPKM 6.8) and 17 other tissues See more
    Orthologs
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    Genomic context

    See Hyls1 in Genome Data Viewer
    Location:
    9; 9 A4
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (35472117..35481365, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (35560821..35570069, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene 1113 Neighboring gene DEAD box helicase 25 Neighboring gene pseudouridine synthase 3 Neighboring gene small cell adhesion glycoprotein family member Neighboring gene high mobility group nucleosomal binding domain 2 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell projection organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in centriole IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in non-motile cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    centriolar and ciliogenesis-associated protein HYLS1
    Names
    hydrolethalus syndrome 1
    hydrolethalus syndrome protein 1 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029762.1NP_084038.1  centriolar and ciliogenesis-associated protein HYLS1

      See identical proteins and their annotated locations for NP_084038.1

      Status: VALIDATED

      Source sequence(s)
      AK013896, AK131639, BY109268
      Consensus CDS
      CCDS52754.1
      UniProtKB/Swiss-Prot
      Q9CXX0
      UniProtKB/TrEMBL
      A0A0R4J1K7
      Related
      ENSMUSP00000110762.4, ENSMUST00000115110.5
      Conserved Domains (1) summary
      pfam15311
      Location:213299
      HYLS1_C; Hydrolethalus syndrome protein 1 C-terminus

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      35472117..35481365 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)