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    Immt inner membrane protein, mitochondrial [ Mus musculus (house mouse) ]

    Gene ID: 76614, updated on 5-Aug-2018

    Summary

    Official Symbol
    Immtprovided by MGI
    Official Full Name
    inner membrane protein, mitochondrialprovided by MGI
    Primary source
    MGI:MGI:1923864
    See related
    Ensembl:ENSMUSG00000052337 Vega:OTTMUSG00000035844
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    HMP; P87; P89; P87/89; 1700082C19Rik; D830041H16Rik
    Expression
    Ubiquitous expression in heart adult (RPKM 50.7), placenta adult (RPKM 32.4) and 28 other tissues See more
    Orthologs

    Genomic context

    See Immt in Genome Data Viewer
    Location:
    6; 6 C1
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 6 NC_000072.6 (71831090..71875266)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (71781325..71825260)

    Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene receptor accessory protein 1 Neighboring gene mitochondrial ribosomal protein L35 Neighboring gene ribosomal protein L7A pseudogene Neighboring gene pentatricopeptide repeat domain 3 Neighboring gene polymerase (RNA) I polypeptide A Neighboring gene eukaryotic translation initiation factor 3, subunit H pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    cristae formation ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrial calcium ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    MICOS complex ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion HDA PubMed 
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    myelin sheath IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    MICOS complex subunit Mic60
    Names
    mitochondrial inner membrane protein
    mitofilin

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001253681.1NP_001240610.1  MICOS complex subunit Mic60 isoform 2

      See identical proteins and their annotated locations for NP_001240610.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice junction in the 5' coding region compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AK049189, BU754623, CJ058627
      Consensus CDS
      CCDS57425.1
      UniProtKB/Swiss-Prot
      Q8CAQ8
      Related
      ENSMUSP00000098859.3, OTTMUSP00000050614, ENSMUST00000101301.9, OTTMUST00000091825
      Conserved Domains (1) summary
      pfam09731
      Location:43734
      Mitofilin; Mitochondrial inner membrane protein
    2. NM_001253686.1NP_001240615.1  MICOS complex subunit Mic60 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice junction in the 5' coding region and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AK152588, AK159909, BU754623, CJ058627
      UniProtKB/TrEMBL
      Q3TVZ5, Q3U7N2
      Conserved Domains (1) summary
      pfam09731
      Location:43729
      Mitofilin; Mitochondrial inner membrane protein
    3. NM_001253687.1NP_001240616.1  MICOS complex subunit Mic60 isoform 4

      See identical proteins and their annotated locations for NP_001240616.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate in-frame splice junction in the 5' coding region and lacks two alternate in-frame exons compared to variant 1. The resulting isoform (4) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AK033126, BU754623, CJ058627
      Consensus CDS
      CCDS57426.1
      UniProtKB/Swiss-Prot
      Q8CAQ8
      Related
      ENSMUSP00000109788.3, OTTMUSP00000050613, ENSMUST00000114151.9, OTTMUST00000091824
      Conserved Domains (1) summary
      pfam09731
      Location:43697
      Mitofilin; Mitochondrial inner membrane protein
    4. NM_001253688.1NP_001240617.1  MICOS complex subunit Mic60 isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (5) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AK038129, AK169365, BU754623, CJ058627
      Consensus CDS
      CCDS57428.1
      UniProtKB/Swiss-Prot
      Q8CAQ8
      UniProtKB/TrEMBL
      E9Q800, Q3TEY5
      Related
      ENSMUSP00000128967.1, OTTMUSP00000050615, ENSMUST00000166938.7, OTTMUST00000091826
      Conserved Domains (1) summary
      pfam09731
      Location:43667
      Mitofilin; Mitochondrial inner membrane protein
    5. NM_001253689.1NP_001240618.1  MICOS complex subunit Mic60 isoform 6

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) lacks two alternate in-frame exons and uses an alternate splice junction in the 3' coding region compared to variant 1, that causes a frameshift. The resulting isoform (6) lacks an alternate internal segment and has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AK146640, BU754623, CJ058627
      Consensus CDS
      CCDS57427.1
      UniProtKB/TrEMBL
      E9QAY6
      Related
      ENSMUSP00000128367.1, OTTMUSP00000050611, ENSMUST00000166975.7, OTTMUST00000091821
      Conserved Domains (1) summary
      pfam09731
      Location:43466
      Mitofilin; Mitochondrial inner membrane protein
    6. NM_001362134.1NP_001349063.1  MICOS complex subunit Mic60 isoform 7

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (7) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC122200
      Conserved Domains (1) summary
      pfam09731
      Location:43708
      Mitofilin; Mitochondrial inner membrane protein
    7. NM_001362136.1NP_001349065.1  MICOS complex subunit Mic60 isoform 8

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) usess an alternate in-frame splice junction in the 5' coding region compared to variant 1. The resulting isoform (8) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC122200
      Conserved Domains (1) summary
      pfam09731
      Location:43733
      Mitofilin; Mitochondrial inner membrane protein
    8. NM_001362137.1NP_001349066.1  MICOS complex subunit Mic60 isoform 9

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (9) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC122200
      Conserved Domains (1) summary
      pfam09731
      Location:43713
      Mitofilin; Mitochondrial inner membrane protein
    9. NM_001362138.1NP_001349067.1  MICOS complex subunit Mic60 isoform 10

      Status: VALIDATED

      Description
      Transcript Variant: This variant (10) uses an alternate in-frame splice junction in the 5' coding region and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (10) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC122200
      Conserved Domains (1) summary
      pfam09731
      Location:43702
      Mitofilin; Mitochondrial inner membrane protein
    10. NM_029673.3NP_083949.2  MICOS complex subunit Mic60 isoform 1

      See identical proteins and their annotated locations for NP_083949.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK038129, BU754623, CJ058627
      Consensus CDS
      CCDS39509.1
      UniProtKB/Swiss-Prot
      Q8CAQ8
      Related
      ENSMUSP00000066181.6, OTTMUSP00000050610, ENSMUST00000064062.12, OTTMUST00000091820
      Conserved Domains (1) summary
      pfam09731
      Location:43745
      Mitofilin; Mitochondrial inner membrane protein

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000072.6 Reference GRCm38.p4 C57BL/6J

      Range
      71831090..71875266
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017321823.1XP_017177312.1  MICOS complex subunit Mic60 isoform X1

    2. XM_017321825.1XP_017177314.1  MICOS complex subunit Mic60 isoform X3

      Conserved Domains (1) summary
      pfam09731
      Location:43713
      Mitofilin; Mitochondrial inner membrane protein
    3. XM_017321826.1XP_017177315.1  MICOS complex subunit Mic60 isoform X4

      Conserved Domains (1) summary
      pfam09731
      Location:43708
      Mitofilin; Mitochondrial inner membrane protein
    4. XM_017321827.1XP_017177316.1  MICOS complex subunit Mic60 isoform X5

      Conserved Domains (1) summary
      pfam09731
      Location:43702
      Mitofilin; Mitochondrial inner membrane protein
    5. XM_017321824.1XP_017177313.1  MICOS complex subunit Mic60 isoform X2

      Conserved Domains (1) summary
      pfam09731
      Location:43733
      Mitofilin; Mitochondrial inner membrane protein
    6. XM_017321828.1XP_017177317.1  MICOS complex subunit Mic60 isoform X6

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