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    Knl1 kinetochore scaffold 1 [ Mus musculus (house mouse) ]

    Gene ID: 76464, updated on 31-Jan-2019

    Summary

    Official Symbol
    Knl1provided by MGI
    Official Full Name
    kinetochore scaffold 1provided by MGI
    Primary source
    MGI:MGI:1923714
    See related
    Ensembl:ENSMUSG00000027326
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Casc5; 2310043D08Rik; 5730505K17Rik
    Expression
    Biased expression in liver E14 (RPKM 4.5), CNS E11.5 (RPKM 3.4) and 10 other tissues See more
    Orthologs

    Genomic context

    See Knl1 in Genome Data Viewer
    Location:
    2; 2 E5
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (119047038..119104829)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (118872855..118929857)

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene RNA pseudouridylate synthase domain containing 2 Neighboring gene nuclear encoded tRNA serine 7 (anticodon GCT) Neighboring gene RAD51 recombinase Neighboring gene regulator of microtubule dynamics 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Transgenic (1) 
    • Targeted (2) 
    • Chemically induced (ENU) (1) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC91208

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    attachment of spindle microtubules to kinetochore ISO
    Inferred from Sequence Orthology
    more info
     
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cell division IEA
    Inferred from Electronic Annotation
    more info
     
    chromosome segregation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein localization to kinetochore ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    acrosomal vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
     
    condensed chromosome kinetochore ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    kinetochore IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    kinetochore scaffold 1; protein CASC5
    Names
    cancer susceptibility candidate 5
    kinetochore-null protein 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001362732.1NP_001349661.1  kinetochore scaffold 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AK009772, AL772264, BC080815
    2. NM_029617.3NP_083893.2  kinetochore scaffold 1 isoform 1

      See identical proteins and their annotated locations for NP_083893.2

      Status: VALIDATED

      Source sequence(s)
      AL772264
      Consensus CDS
      CCDS38203.1
      UniProtKB/TrEMBL
      A3KGI3
      Related
      ENSMUSP00000097140.2, ENSMUST00000099542.8
      Conserved Domains (1) summary
      pfam08317
      Location:16761942
      Spc7; Spc7 kinetochore protein

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

      Range
      119047038..119104829
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006500376.2XP_006500439.1  protein CASC5 isoform X1

      See identical proteins and their annotated locations for XP_006500439.1

      UniProtKB/TrEMBL
      A3KGI3
      Conserved Domains (1) summary
      pfam08317
      Location:16761942
      Spc7; Spc7 kinetochore protein
    2. XM_006500377.3XP_006500440.1  protein CASC5 isoform X1

      See identical proteins and their annotated locations for XP_006500440.1

      UniProtKB/TrEMBL
      A3KGI3
      Related
      ENSMUSP00000028802.2, ENSMUST00000028802.2
      Conserved Domains (1) summary
      pfam08317
      Location:16761942
      Spc7; Spc7 kinetochore protein
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