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    Knl1 kinetochore scaffold 1 [ Mus musculus (house mouse) ]

    Gene ID: 76464, updated on 23-Jun-2021

    Summary

    Official Symbol
    Knl1provided by MGI
    Official Full Name
    kinetochore scaffold 1provided by MGI
    Primary source
    MGI:MGI:1923714
    See related
    Ensembl:ENSMUSG00000027326
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cas; Casc5; 2310043D08Rik; 5730505K17Rik
    Expression
    Biased expression in liver E14 (RPKM 4.5), CNS E11.5 (RPKM 3.4) and 10 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Knl1 in Genome Data Viewer
    Location:
    2; 2 E5
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (118877600..118940978)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (119047119..119110497)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (118872855..118929857)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene RNA pseudouridylate synthase domain containing 2 Neighboring gene nuclear encoded tRNA serine 7 (anticodon GCT) Neighboring gene RAD51 recombinase Neighboring gene regulator of microtubule dynamics 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Transgenic (1) 
    • Targeted (3)  1 citation
    • Chemically induced (ENU) (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC91208

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    involved_in attachment of spindle microtubules to kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in attachment of spindle microtubules to kinetochore ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within chromosome segregation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein localization to kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within protein localization to kinetochore ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in acrosomal vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in kinetochore ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    kinetochore scaffold 1
    Names
    cancer susceptibility candidate 5
    kinetochore-null protein 1
    protein CASC5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001362732.1NP_001349661.1  kinetochore scaffold 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AK009772, AL772264, BC080815
      Consensus CDS
      CCDS89540.1
      Related
      ENSMUSP00000028799.6, ENSMUST00000028799.12
    2. NM_029617.3NP_083893.2  kinetochore scaffold 1 isoform 1

      See identical proteins and their annotated locations for NP_083893.2

      Status: VALIDATED

      Source sequence(s)
      AL772264
      Consensus CDS
      CCDS38203.1
      UniProtKB/TrEMBL
      A3KGI3
      Related
      ENSMUSP00000097140.3, ENSMUST00000099542.9
      Conserved Domains (2) summary
      COG1196
      Location:17241912
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam18210
      Location:20212118
      Knl1_RWD_C; Knl1 RWD C-terminal domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      118877600..118940978
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006500376.4XP_006500439.1  kinetochore scaffold 1 isoform X1

      See identical proteins and their annotated locations for XP_006500439.1

      UniProtKB/TrEMBL
      A3KGI3
      Conserved Domains (2) summary
      COG1196
      Location:17241912
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam18210
      Location:20212118
      Knl1_RWD_C; Knl1 RWD C-terminal domain
    2. XM_006500377.5XP_006500440.1  kinetochore scaffold 1 isoform X1

      See identical proteins and their annotated locations for XP_006500440.1

      UniProtKB/TrEMBL
      A3KGI3
      Related
      ENSMUSP00000028802.3, ENSMUST00000028802.3
      Conserved Domains (2) summary
      COG1196
      Location:17241912
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam18210
      Location:20212118
      Knl1_RWD_C; Knl1 RWD C-terminal domain
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