Rab1b RAB1B, member RAS oncogene family [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rab1bprovided by MGI
Official Full Name: RAB1B, member RAS oncogene familyprovided by MGI
Primary source: MGI:MGI:1923558
See related: Ensembl:ENSMUSG00000024870
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1110011F09Rik
Expression: Ubiquitous expression in subcutaneous fat pad adult (RPKM 59.5), genital fat pad adult (RPKM 55.0) and 28 other tissues See more
Orthologs: human all

Genomic context

Location:: 19; 19 A

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
106	current	GRCm38.p4 (GCF_000001635.24)	19	NC_000085.6 (5099207..5106996, complement)
Build 37.2	previous assembly	MGSCv37 (GCF_000001635.18)	19	NC_000085.5 (5099207..5106996, complement)

Chromosome 19 - NC_000085.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

identify Rap1b acting downstream of Axin2 as a signaling interrogator for FGF and BMP. Genetic analysis reveals that Rap1b is essential for development of craniofacial and body skeletons. Axin2 regulates Rap1b through modulation of canonical BMP signaling.
Title: Rap1b Is an Effector of Axin2 Regulating Crosstalk of Signaling Pathways During Skeletal Development.
Inhibition of PI3K or mTOR reduced the level of Rap1B, which acts downstream of Rheb and mTOR. The ubiquitin E3 ligase Smurf2 mediates the restriction of Rap1B by initiating its degradation.
Title: Rheb and mTOR regulate neuronal polarity through Rap1B.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)

Pathways from BioSystems

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Asparagine N-linked glycosylation, organism-specific biosystem (from REACTOME)
Asparagine N-linked glycosylation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
COPI-dependent Golgi-to-ER retrograde traffic, organism-specific biosystem (from REACTOME)
COPI-dependent Golgi-to-ER retrograde traffic, organism-specific biosystemcomputationally inferred pathway (not manually curated)
COPI-mediated anterograde transport, organism-specific biosystem (from REACTOME)
COPI-mediated anterograde transport, organism-specific biosystemcomputationally inferred pathway (not manually curated)
COPII (Coat Protein 2) Mediated Vesicle Transport, organism-specific biosystem (from REACTOME)
COPII (Coat Protein 2) Mediated Vesicle Transport, organism-specific biosystemcomputationally inferred pathway (not manually curated)
ER to Golgi Anterograde Transport, organism-specific biosystem (from REACTOME)
ER to Golgi Anterograde Transport, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Golgi-to-ER retrograde transport, organism-specific biosystem (from REACTOME)
Golgi-to-ER retrograde transport, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Intra-Golgi and retrograde Golgi-to-ER traffic, organism-specific biosystem (from REACTOME)
Intra-Golgi and retrograde Golgi-to-ER traffic, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Legionellosis, organism-specific biosystem (from KEGG)
Legionellosis, organism-specific biosystemLegionellosis is a potentially fatal infectious disease caused by the bacterium Legionella pneumophila and other legionella species. Two distinct clinical and epidemiological syndromes are associated...
Legionellosis, conserved biosystem (from KEGG)
Legionellosis, conserved biosystemLegionellosis is a potentially fatal infectious disease caused by the bacterium Legionella pneumophila and other legionella species. Two distinct clinical and epidemiological syndromes are associated...
Membrane Trafficking, organism-specific biosystem (from REACTOME)
Membrane Trafficking, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Metabolism of proteins, organism-specific biosystem (from REACTOME)
Metabolism of proteins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Post-translational protein modification, organism-specific biosystem (from REACTOME)
Post-translational protein modification, organism-specific biosystemcomputationally inferred pathway (not manually curated)
RAB geranylgeranylation, organism-specific biosystem (from REACTOME)
RAB geranylgeranylation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Transport to the Golgi and subsequent modification, organism-specific biosystem (from REACTOME)
Transport to the Golgi and subsequent modification, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
Vesicle-mediated transport, organism-specific biosystemcomputationally inferred pathway (not manually curated)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Homologs of the Rab1b gene: The Rab1b gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, and zebrafish.
Orthologs from Annotation Pipeline: 118 organisms have orthologs with human gene Rab1b
The Hierarchical Catalog of Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
GTP binding	ISO Inferred from Sequence Orthology more info
GTPase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
ER to Golgi vesicle-mediated transport	ISO Inferred from Sequence Orthology more info
Rab protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info	PubMed
autophagy	IEA Inferred from Electronic Annotation more info
intracellular protein transport	IBA Inferred from Biological aspect of Ancestor more info	PubMed
positive regulation of glycoprotein metabolic process	ISO Inferred from Sequence Orthology more info
protein transport	IEA Inferred from Electronic Annotation more info
regulation of autophagosome assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
Golgi apparatus	ISO Inferred from Sequence Orthology more info
Golgi membrane	IBA Inferred from Biological aspect of Ancestor more info	PubMed
cytoplasm	IEA Inferred from Electronic Annotation more info
endoplasmic reticulum-Golgi intermediate compartment	IDA Inferred from Direct Assay more info	PubMed
membrane	IEA Inferred from Electronic Annotation more info
mitochondrion	HDA more info	PubMed
phagophore assembly site membrane	ISO Inferred from Sequence Orthology more info
synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ras-related protein Rab-1B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.