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    Osbp oxysterol binding protein [ Mus musculus (house mouse) ]

    Gene ID: 76303, updated on 9-Sep-2018

    Summary

    Official Symbol
    Osbpprovided by MGI
    Official Full Name
    oxysterol binding proteinprovided by MGI
    Primary source
    MGI:MGI:97447
    See related
    Ensembl:ENSMUSG00000024687
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AW559088; mKIAA4220; 1110018F06Rik
    Expression
    Ubiquitous expression in placenta adult (RPKM 14.9), heart adult (RPKM 13.5) and 28 other tissues See more
    Orthologs

    Genomic context

    See Osbp in Genome Data Viewer
    Location:
    19 A; 19 8.58 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 19 NC_000085.6 (11965844..11994114)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (12040334..12068604)

    Chromosome 19 - NC_000085.6Genomic Context describing neighboring genes Neighboring gene protein associated with topoisomerase II homolog 1 (yeast) Neighboring gene microRNA 6994 Neighboring gene uncharacterized protein C11orf98 homolog pseudogene Neighboring gene nuclear encoded tRNA pheylalanine 6 (anticodon GAA) Neighboring gene nuclear encoded tRNA lysine 29 (anticodon TTT)

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA4220

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    lipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    phosphatidylinositol-4-phosphate binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    sterol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    sterol transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    sterol transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    intracellular cholesterol transport ISO
    Inferred from Sequence Orthology
    more info
     
    lipid transport IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of growth of symbiont in host ISO
    Inferred from Sequence Orthology
    more info
     
    sterol transport ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
     
    cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    perinuclear endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    oxysterol-binding protein 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033174.1NP_001028346.1  oxysterol-binding protein 1

      See identical proteins and their annotated locations for NP_001028346.1

      Status: VALIDATED

      Source sequence(s)
      AI450082, AK220301, BC107327, CJ163670
      Consensus CDS
      CCDS37925.1
      UniProtKB/Swiss-Prot
      Q3B7Z2
      Related
      ENSMUSP00000025590.9, ENSMUST00000025590.9
      Conserved Domains (3) summary
      cd13284
      Location:89187
      PH_OSBP_ORP4; Human Oxysterol binding protein and OSBP-related protein 4 Pleckstrin homology (PH) domain
      pfam00169
      Location:89179
      PH; PH domain
      pfam01237
      Location:416785
      Oxysterol_BP; Oxysterol-binding protein

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000085.6 Reference GRCm38.p4 C57BL/6J

      Range
      11965844..11994114
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006527439.3XP_006527502.1  oxysterol-binding protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006527502.1

      UniProtKB/Swiss-Prot
      Q3B7Z2
      Conserved Domains (1) summary
      pfam01237
      Location:148517
      Oxysterol_BP; Oxysterol-binding protein
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