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    Atp11b ATPase, class VI, type 11B [ Mus musculus (house mouse) ]

    Gene ID: 76295, updated on 17-Jul-2021

    Summary

    Official Symbol
    Atp11bprovided by MGI
    Official Full Name
    ATPase, class VI, type 11Bprovided by MGI
    Primary source
    MGI:MGI:1923545
    See related
    Ensembl:ENSMUSG00000037400
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ATPIF; ATPIR; mKIAA0956; 1110019I14Rik
    Expression
    Ubiquitous expression in frontal lobe adult (RPKM 18.5), CNS E18 (RPKM 15.8) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Atp11b in Genome Data Viewer
    Location:
    3; 3 B
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (35808104..35910425)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (35754044..35856276)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (35653060..35755198)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene 6639 Neighboring gene predicted gene, 25696 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene chaperonin containing Tcp1, subunit 8 (theta) pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (1) 

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATPase-coupled intramembrane lipid transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within lipid transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in phospholipid translocation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in phospholipid transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in recycling endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in recycling endosome ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    phospholipid-transporting ATPase IF; probable phospholipid-transporting ATPase IF
    Names
    P4-ATPase flippase complex alpha subunit ATP11B
    NP_083846.2
    XP_006535637.1
    XP_030108731.1
    XP_030108733.1
    XP_036019283.1
    XP_036019284.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029570.4NP_083846.2  phospholipid-transporting ATPase IF

      See identical proteins and their annotated locations for NP_083846.2

      Status: VALIDATED

      Source sequence(s)
      BC076603, CF952078, CJ128477, CN535194
      Consensus CDS
      CCDS38414.1
      UniProtKB/TrEMBL
      Q6DFW5
      Related
      ENSMUSP00000029257.9, ENSMUST00000029257.15
      Conserved Domains (6) summary
      TIGR01652
      Location:391105
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
      pfam00122
      Location:96180
      E1-E2_ATPase; E1-E2 ATPase
      pfam13246
      Location:493604
      Cation_ATPase; Cation transport ATPase (P-type)
      pfam16209
      Location:2189
      PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
      pfam16212
      Location:8461099
      PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
      cl21460
      Location:628867
      HAD_like; Haloacid Dehalogenase-like Hydrolases

    RNA

    1. NR_151626.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC157780, BC076603
    2. NR_151627.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC157780, BC076603

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      35808104..35910425
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036163391.1XP_036019284.1  probable phospholipid-transporting ATPase IF isoform X4

      Conserved Domains (1) summary
      cl21460
      Location:13590
      HAD_like; Haloacid Dehalogenase-like Hydrolases
    2. XM_036163390.1XP_036019283.1  probable phospholipid-transporting ATPase IF isoform X1

      Related
      ENSMUSP00000142676.2, ENSMUST00000198599.2
      Conserved Domains (1) summary
      cd02073
      Location:41978
      P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C
    3. XM_006535574.4XP_006535637.1  probable phospholipid-transporting ATPase IF isoform X3

      Related
      ENSMUST00000200445.5
      Conserved Domains (1) summary
      cd02073
      Location:41835
      P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C
    4. XM_030252871.1XP_030108731.1  probable phospholipid-transporting ATPase IF isoform X2

      Conserved Domains (2) summary
      cd02073
      Location:1715
      P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C
      cl28910
      Location:654800
      MFS; Major Facilitator Superfamily
    5. XM_030252873.1XP_030108733.1  probable phospholipid-transporting ATPase IF isoform X4

      Conserved Domains (1) summary
      cl21460
      Location:13590
      HAD_like; Haloacid Dehalogenase-like Hydrolases
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