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    Abhd12 abhydrolase domain containing 12 [ Mus musculus (house mouse) ]

    Gene ID: 76192, updated on 31-Jan-2019

    Summary

    Official Symbol
    Abhd12provided by MGI
    Official Full Name
    abhydrolase domain containing 12provided by MGI
    Primary source
    MGI:MGI:1923442
    See related
    Ensembl:ENSMUSG00000032046
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AI431047; AW547313; 1500011G07Rik; 6330583M11Rik
    Expression
    Ubiquitous expression in cortex adult (RPKM 64.9), bladder adult (RPKM 63.9) and 28 other tissues See more
    Orthologs

    Genomic context

    See Abhd12 in Genome Data Viewer
    Location:
    2; 2 G3
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (150832493..150904731, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (150658251..150730467, complement)

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30141 Neighboring gene brain glycogen phosphorylase Neighboring gene GINS complex subunit 1 (Psf1 homolog) Neighboring gene ribosomal protein L41 pseudogene Neighboring gene eukaryotic translation initiation factor 4E-binding protein 1 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    acylglycerol lipase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acylglycerol lipase activity ISO
    Inferred from Sequence Orthology
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    lysophospholipase activity ISO
    Inferred from Sequence Orthology
    more info
     
    palmitoyl-(protein) hydrolase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    acylglycerol catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acylglycerol catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    adult walking behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    glycerophospholipid catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    monoacylglycerol catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    phosphatidylserine catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein depalmitoylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to auditory stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    AMPA glutamate receptor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dendrite cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    monoacylglycerol lipase ABHD12
    Names
    2-arachidonoylglycerol hydrolase
    abhydrolase domain-containing protein 12
    NP_077785.2
    XP_006500428.1
    XP_006500429.1
    XP_006500430.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356549.1NP_001343478.1  monoacylglycerol lipase ABHD12 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AL808125, AL954712
      Conserved Domains (1) summary
      cl26327
      Location:8215
      Abhydrolase_1; alpha/beta hydrolase fold
    2. NM_001356550.1NP_001343479.1  monoacylglycerol lipase ABHD12 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AL808125, AL954712
      Conserved Domains (1) summary
      cl26327
      Location:1153
      Abhydrolase_1; alpha/beta hydrolase fold
    3. NM_024465.3NP_077785.2  monoacylglycerol lipase ABHD12 isoform 1

      See identical proteins and their annotated locations for NP_077785.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AL808125, AL954712
      Consensus CDS
      CCDS50742.1
      UniProtKB/Swiss-Prot
      Q99LR1
      Related
      ENSMUSP00000053558.8, ENSMUST00000056149.14
      Conserved Domains (2) summary
      pfam12146
      Location:165372
      Hydrolase_4; Serine aminopeptidase, S33
      pfam12695
      Location:171355
      Abhydrolase_5; Alpha/beta hydrolase family

    RNA

    1. NR_151505.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate splice junction compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AL808125, AL954712

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

      Range
      150832493..150904731 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006500366.3XP_006500429.1  monoacylglycerol lipase ABHD12 isoform X2

      Conserved Domains (1) summary
      cl26327
      Location:8215
      Abhydrolase_1; alpha/beta hydrolase fold
    2. XM_006500367.3XP_006500430.1  monoacylglycerol lipase ABHD12 isoform X2

      See identical proteins and their annotated locations for XP_006500430.1

      Conserved Domains (1) summary
      cl26327
      Location:8215
      Abhydrolase_1; alpha/beta hydrolase fold
    3. XM_006500365.3XP_006500428.1  monoacylglycerol lipase ABHD12 isoform X1

      Conserved Domains (2) summary
      pfam12146
      Location:111318
      Hydrolase_4; Serine aminopeptidase, S33
      pfam12695
      Location:117301
      Abhydrolase_5; Alpha/beta hydrolase family
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