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    Adhfe1 alcohol dehydrogenase, iron containing, 1 [ Mus musculus (house mouse) ]

    Gene ID: 76187, updated on 23-Jun-2021

    Summary

    Official Symbol
    Adhfe1provided by MGI
    Official Full Name
    alcohol dehydrogenase, iron containing, 1provided by MGI
    Primary source
    MGI:MGI:1923437
    See related
    Ensembl:ENSMUSG00000025911
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    HOT; Adh8; AI043035; 6330565B14Rik
    Expression
    Biased expression in kidney adult (RPKM 62.9), subcutaneous fat pad adult (RPKM 31.2) and 10 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Adhfe1 in Genome Data Viewer
    Location:
    1; 1 A2
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (9618173..9648195)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (9547948..9577970)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (9538127..9568049)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene cytochrome b5 reductase 4 pseudogene Neighboring gene RIKEN cDNA 2610203C22 gene Neighboring gene ribosome biogenesis regulator 1 Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene Neighboring gene vexin Neighboring gene VISTA enhancer mm1546

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables alcohol dehydrogenase (NAD+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables hydroxyacid-oxoacid transhydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in glutamate catabolic process via 2-oxoglutarate ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    hydroxyacid-oxoacid transhydrogenase, mitochondrial
    Names
    Fe-containing alcohol dehydrogenase 1
    alcohol dehydrogenase 8
    alcohol dehydrogenase iron-containing protein 1
    NP_001344305.1
    NP_001344306.1
    NP_001344307.1
    NP_780445.1
    XP_006495649.1
    XP_036010127.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357376.1NP_001344305.1  hydroxyacid-oxoacid transhydrogenase, mitochondrial isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC103620
      Conserved Domains (1) summary
      cd08190
      Location:3416
      HOT; Hydroxyacid-oxoacid transhydrogenase (HOT) involved in gamma-hydroxybutyrate metabolism
    2. NM_001357377.1NP_001344306.1  hydroxyacid-oxoacid transhydrogenase, mitochondrial isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC103620
      Conserved Domains (1) summary
      cd08190
      Location:3416
      HOT; Hydroxyacid-oxoacid transhydrogenase (HOT) involved in gamma-hydroxybutyrate metabolism
    3. NM_001357378.1NP_001344307.1  hydroxyacid-oxoacid transhydrogenase, mitochondrial isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC103620
      Conserved Domains (1) summary
      cd08190
      Location:1394
      HOT; Hydroxyacid-oxoacid transhydrogenase (HOT) involved in gamma-hydroxybutyrate metabolism
    4. NM_175236.5NP_780445.1  hydroxyacid-oxoacid transhydrogenase, mitochondrial isoform 1

      See identical proteins and their annotated locations for NP_780445.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC103620, AK038853, AW494922
      Consensus CDS
      CCDS14812.1
      UniProtKB/Swiss-Prot
      Q8R0N6
      Related
      ENSMUSP00000116627.2, ENSMUST00000144177.8
      Conserved Domains (1) summary
      cd08190
      Location:49462
      HOT; Hydroxyacid-oxoacid transhydrogenase (HOT) involved in gamma-hydroxybutyrate metabolism

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      9618173..9648195
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036154234.1XP_036010127.1  hydroxyacid-oxoacid transhydrogenase, mitochondrial isoform X1

      Conserved Domains (1) summary
      cd08190
      Location:17430
      HOT; Hydroxyacid-oxoacid transhydrogenase (HOT) involved in gamma-hydroxybutyrate metabolism
    2. XM_006495586.4XP_006495649.1  hydroxyacid-oxoacid transhydrogenase, mitochondrial isoform X2

      See identical proteins and their annotated locations for XP_006495649.1

      UniProtKB/Swiss-Prot
      Q8R0N6
      Conserved Domains (1) summary
      cd08190
      Location:3416
      HOT; Hydroxyacid-oxoacid transhydrogenase (HOT) involved in gamma-hydroxybutyrate metabolism
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