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    Gpsm2 G-protein signalling modulator 2 (AGS3-like, C. elegans) [ Mus musculus (house mouse) ]

    Gene ID: 76123, updated on 7-Sep-2021

    Summary

    Official Symbol
    Gpsm2provided by MGI
    Official Full Name
    G-protein signalling modulator 2 (AGS3-like, C. elegans)provided by MGI
    Primary source
    MGI:MGI:1923373
    See related
    Ensembl:ENSMUSG00000027883
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    L; LGN; Pins; 6230410J09Rik
    Expression
    Broad expression in CNS E11.5 (RPKM 14.3), limb E14.5 (RPKM 14.1) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Gpsm2 in Genome Data Viewer
    Location:
    3; 3 F3
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (108585954..108629637, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (108678270..108722331, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (108481556..108525217, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene TATA-box binding protein associated factor 13 Neighboring gene WD repeat domain 47 Neighboring gene 40S ribosomal protein S23 pseudogene Neighboring gene chloride channel CLIC-like 1 Neighboring gene AKNA domain containing 1 Neighboring gene syntaxin binding protein 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G-protein alpha-subunit binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables GDP-dissociation inhibitor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables GTPase regulator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables dynein complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein C-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein self-association ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in apical part of cell IDA
    Inferred from Direct Assay
    more info
     
    colocalizes_with cell cortex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell cortex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell cortex region ISO
    Inferred from Sequence Orthology
    more info
     
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lateral cell cortex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lateral cell cortex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with mitotic spindle pole ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitotic spindle pole ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    G-protein-signaling modulator 2
    Names
    pins homolog (Drosophia)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029522.2NP_083798.2  G-protein-signaling modulator 2

      See identical proteins and their annotated locations for NP_083798.2

      Status: VALIDATED

      Source sequence(s)
      AK143552, AY081187
      Consensus CDS
      CCDS51048.1
      UniProtKB/Swiss-Prot
      Q8VDU0
      UniProtKB/TrEMBL
      Q3UPG3
      Related
      ENSMUSP00000029482.9, ENSMUST00000029482.16
      Conserved Domains (6) summary
      smart00390
      Location:490512
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      sd00006
      Location:243270
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:243274
      TPR_1; Tetratricopeptide repeat
      pfam02188
      Location:629650
      GoLoco; GoLoco motif
      pfam13176
      Location:284318
      TPR_7; Tetratricopeptide repeat
      pfam13424
      Location:243314
      TPR_12; Tetratricopeptide repeat

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      108585954..108629637 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006502256.5XP_006502319.1  G-protein-signaling modulator 2 isoform X1

      Conserved Domains (5) summary
      smart00390
      Location:471493
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      COG0457
      Location:8267
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:224251
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:224295
      TPR_12; Tetratricopeptide repeat
      pfam02188
      Location:611631
      GoLoco; GoLoco motif
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