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    CA3 carbonic anhydrase 3 [ Homo sapiens (human) ]

    Gene ID: 761, updated on 27-Nov-2024

    Summary

    Official Symbol
    CA3provided by HGNC
    Official Full Name
    carbonic anhydrase 3provided by HGNC
    Primary source
    HGNC:HGNC:1374
    See related
    Ensembl:ENSG00000164879 MIM:114750; AllianceGenome:HGNC:1374
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Car3; CAIII
    Summary
    Carbonic anhydrase III (CAIII) is a member of a multigene family (at least six separate genes are known) that encodes carbonic anhydrase isozymes. These carbonic anhydrases are a class of metalloenzymes that catalyze the reversible hydration of carbon dioxide and are differentially expressed in a number of cell types. The expression of the CA3 gene is strictly tissue specific and present at high levels in skeletal muscle and much lower levels in cardiac and smooth muscle. A proportion of carriers of Duchenne muscle dystrophy have a higher CA3 level than normal. The gene spans 10.3 kb and contains seven exons and six introns. [provided by RefSeq, Oct 2008]
    Expression
    Biased expression in prostate (RPKM 78.7), fat (RPKM 38.8) and 3 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See CA3 in Genome Data Viewer
    Location:
    8q21.2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (85438859..85449040)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (85877589..85887769)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (86351088..86361269)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19336 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27594 Neighboring gene carbonic anhydrase 13 Neighboring gene NANOG hESC enhancer GRCh37_chr8:86229148-86229679 Neighboring gene uncharacterized LOC124901970 Neighboring gene carbonic anhydrase 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27595 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19337 Neighboring gene CA1 upstream erythroid promoter Neighboring gene NANOG hESC enhancer GRCh37_chr8:86316751-86317252 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:86350401-86350924 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:86350925-86351447 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr8:86373749-86374444 Neighboring gene CA3 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19338 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19339 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:86376345-86376844 Neighboring gene uncharacterized LOC105375937 Neighboring gene carbonic anhydrase 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Potential readthrough

    Included gene: CA13

    Clone Names

    • FLJ36434

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables carbonate dehydratase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables carbonate dehydratase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables nickel cation binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in response to bacterium IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    carbonic anhydrase 3
    Names
    CA-III
    HEL-S-167mP
    carbonate dehydratase III
    carbonic anhydrase III, muscle specific
    carbonic anhydrase IIII
    epididymis secretory sperm binding protein Li 167mP
    NP_005172.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_005181.4NP_005172.1  carbonic anhydrase 3

      See identical proteins and their annotated locations for NP_005172.1

      Status: REVIEWED

      Source sequence(s)
      AC084734, AK313254, DA421884
      Consensus CDS
      CCDS6238.1
      UniProtKB/Swiss-Prot
      B2R867, B3KUC8, O60842, P07451
      UniProtKB/TrEMBL
      B4DUJ8, V9HWA3
      Related
      ENSP00000285381.2, ENST00000285381.3
      Conserved Domains (1) summary
      cd03119
      Location:1259
      alpha_CA_I_II_III_XIII; Carbonic anhydrase alpha, isozymes I, II, and III and XIII. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      85438859..85449040
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      85877589..85887769
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)