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    Rapgef2 Rap guanine nucleotide exchange factor (GEF) 2 [ Mus musculus (house mouse) ]

    Gene ID: 76089, updated on 28-Oct-2018

    Summary

    Official Symbol
    Rapgef2provided by MGI
    Official Full Name
    Rap guanine nucleotide exchange factor (GEF) 2provided by MGI
    Primary source
    MGI:MGI:2659071
    See related
    Ensembl:ENSMUSG00000062232 Vega:OTTMUSG00000031912
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pdzgef1; nRapGEP; CNRasGEF; RA-GEF-1; mKIAA0313; 5830453M24Rik
    Expression
    Ubiquitous expression in frontal lobe adult (RPKM 10.4), cortex adult (RPKM 8.4) and 27 other tissues See more
    Orthologs

    Genomic context

    See Rapgef2 in Genome Data Viewer
    Location:
    3; 3 E3
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 3 NC_000069.6 (79062511..79287241, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (78866450..78949797, complement)

    Chromosome 3 - NC_000069.6Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene predicted gene, 38542 Neighboring gene ubiquitin-conjugating enzyme E2D 2 pseudogene Neighboring gene RIKEN cDNA 4921511C10 gene Neighboring gene predicted gene, 40072 Neighboring gene predicted gene, 17359 Neighboring gene folliculin interacting protein 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    PDZ domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    Rap guanyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Rap guanyl-nucleotide exchange factor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Rap guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Ras guanyl-nucleotide exchange factor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Ras guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    WW domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    beta-1 adrenergic receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatidic acid binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    Rap protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    adenylate cyclase-activating adrenergic receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    blood vessel development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    brain-derived neurotrophic factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    cAMP-mediated signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cAMP-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
     
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to cAMP IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to cAMP IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to cAMP ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to cGMP ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to nerve growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    establishment of endothelial barrier ISO
    Inferred from Sequence Orthology
    more info
     
    establishment of endothelial intestinal barrier ISO
    Inferred from Sequence Orthology
    more info
     
    forebrain neuron development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    microvillus assembly ISO
    Inferred from Sequence Orthology
    more info
     
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of dendrite morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of dendrite morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of melanin biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    nerve growth factor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    nervous system development IEA
    Inferred from Electronic Annotation
    more info
     
    neuron migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    neuropeptide signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuropeptide signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of ERK1 and ERK2 cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of ERK1 and ERK2 cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of GTPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of GTPase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cAMP-dependent protein kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cAMP-dependent protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cAMP-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of dendritic cell apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of dendritic cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of neuron migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of vasculogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cell junction assembly ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of synaptic plasticity ISO
    Inferred from Sequence Orthology
    more info
     
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    small GTPase mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    ventricular system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    bicellular tight junction ISO
    Inferred from Sequence Orthology
    more info
     
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    endocytic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    endosome IEA
    Inferred from Electronic Annotation
    more info
     
    late endosome ISO
    Inferred from Sequence Orthology
    more info
     
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    synapse ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    rap guanine nucleotide exchange factor 2
    Names
    PDZ domain-containing guanine nucleotide exchange factor 1
    cyclic nucleotide ras GEF
    neural RAP guanine nucleotide exchange protein
    ras/Rap1-associating GEF-1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001099624.3NP_001093094.2  rap guanine nucleotide exchange factor 2 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK147368, BC067056, BP758717
      Consensus CDS
      CCDS50932.1
      UniProtKB/TrEMBL
      E9QNQ4, Q6NXI4
      Related
      ENSMUSP00000113778.1, OTTMUSP00000042163, ENSMUST00000118340.6, OTTMUST00000079130
      Conserved Domains (5) summary
      smart00100
      Location:134249
      cNMP; Cyclic nucleotide-monophosphate binding domain
      smart00229
      Location:265378
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00155
      Location:711936
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:382462
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cl00155
      Location:604688
      UBQ; Ubiquitin-like proteins
    2. NM_001310536.1NP_001297465.1  rap guanine nucleotide exchange factor 2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream in-frame start site compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.
      Source sequence(s)
      AK147368, BC067056, BP758717
      UniProtKB/TrEMBL
      Q6NXI4
      Conserved Domains (5) summary
      smart00100
      Location:64179
      cNMP; Cyclic nucleotide-monophosphate binding domain
      smart00229
      Location:195308
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00155
      Location:641866
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:312392
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cl00155
      Location:534618
      UBQ; Ubiquitin-like proteins

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000069.6 Reference GRCm38.p4 C57BL/6J

      Range
      79062511..79287241 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006502250.3XP_006502313.1  rap guanine nucleotide exchange factor 2 isoform X2

      Conserved Domains (7) summary
      smart00100
      Location:291406
      cNMP; Cyclic nucleotide-monophosphate binding domain
      smart00229
      Location:422535
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      COG0664
      Location:31147
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      cd00038
      Location:37143
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd00155
      Location:8681093
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:539619
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cl00155
      Location:761845
      UBQ; Ubiquitin-like proteins
    2. XM_011240277.2XP_011238579.1  rap guanine nucleotide exchange factor 2 isoform X3

      Conserved Domains (7) summary
      smart00100
      Location:297412
      cNMP; Cyclic nucleotide-monophosphate binding domain
      smart00229
      Location:428541
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      COG0664
      Location:31147
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      cd00038
      Location:37143
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd00155
      Location:8741078
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:545625
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cl00155
      Location:767851
      UBQ; Ubiquitin-like proteins
    3. XM_011240276.2XP_011238578.1  rap guanine nucleotide exchange factor 2 isoform X1

      Related
      ENSMUSP00000141542.1, OTTMUSP00000070181, ENSMUST00000195708.1, OTTMUST00000131132
      Conserved Domains (7) summary
      smart00100
      Location:297412
      cNMP; Cyclic nucleotide-monophosphate binding domain
      smart00229
      Location:428541
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      COG0664
      Location:31147
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      cd00038
      Location:37143
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd00155
      Location:8741099
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:545625
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cl00155
      Location:767851
      UBQ; Ubiquitin-like proteins
    4. XM_006502252.3XP_006502315.1  rap guanine nucleotide exchange factor 2 isoform X4

      Conserved Domains (5) summary
      smart00100
      Location:181296
      cNMP; Cyclic nucleotide-monophosphate binding domain
      smart00229
      Location:312425
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00155
      Location:758983
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:429509
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cl00155
      Location:651735
      UBQ; Ubiquitin-like proteins
    5. XM_006502254.3XP_006502317.1  rap guanine nucleotide exchange factor 2 isoform X5

      See identical proteins and their annotated locations for XP_006502317.1

      UniProtKB/Swiss-Prot
      Q8CHG7
      Related
      ENSMUSP00000114119.1, OTTMUSP00000042162, ENSMUST00000118100.7, OTTMUST00000079129
      Conserved Domains (5) summary
      smart00100
      Location:136251
      cNMP; Cyclic nucleotide-monophosphate binding domain
      smart00229
      Location:267380
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00155
      Location:713938
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:384464
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cl00155
      Location:606690
      UBQ; Ubiquitin-like proteins
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