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    Rapgef2 Rap guanine nucleotide exchange factor (GEF) 2 [ Mus musculus (house mouse) ]

    Gene ID: 76089, updated on 23-Jun-2021

    Summary

    Official Symbol
    Rapgef2provided by MGI
    Official Full Name
    Rap guanine nucleotide exchange factor (GEF) 2provided by MGI
    Primary source
    MGI:MGI:2659071
    See related
    Ensembl:ENSMUSG00000062232
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    nR; CNRa; Pdzgef; RA-GEF; Pdzgef1; nRapGEP; CNRasGEF; RA-GEF-1; mKIAA0313; 5830453M24Rik
    Expression
    Ubiquitous expression in frontal lobe adult (RPKM 10.4), cortex adult (RPKM 8.4) and 27 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Rapgef2 in Genome Data Viewer
    Location:
    3; 3 E3
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (78969818..79194681, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (79062511..79286545, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (78866450..78949797, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 23440 Neighboring gene predicted gene, 52609 Neighboring gene RIKEN cDNA 4921511C10 gene Neighboring gene predicted gene, 24150 Neighboring gene RIKEN cDNA 6430573P05 gene Neighboring gene predicted gene, 40072 Neighboring gene predicted gene, 17359 Neighboring gene folliculin interacting protein 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (4)  1 citation
    • Endonuclease-mediated (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables PDZ domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables WW domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables beta-1 adrenergic receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables guanyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables guanyl-nucleotide exchange factor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidic acid binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in Rap protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in adenylate cyclase-activating adrenergic receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in blood vessel development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in brain-derived neurotrophic factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cAMP-mediated signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cAMP-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to cAMP IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to cAMP IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to cAMP ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to cGMP ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to nerve growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in establishment of endothelial barrier ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in establishment of endothelial intestinal barrier ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in forebrain neuron development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in microvillus assembly ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of dendrite morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of dendrite morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of melanin biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in nerve growth factor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within nervous system development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neuron migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuropeptide signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in neuropeptide signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of ERK1 and ERK2 cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of GTPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of GTPase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cAMP-dependent protein kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cAMP-dependent protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cAMP-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of dendritic cell apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of dendritic cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of neuron migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of vasculogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell junction assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of synaptic plasticity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in small GTPase mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ventricular system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in bicellular tight junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endocytic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in late endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in synapse ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    rap guanine nucleotide exchange factor 2
    Names
    PDZ domain-containing guanine nucleotide exchange factor 1
    cyclic nucleotide ras GEF
    neural RAP guanine nucleotide exchange protein
    ras/Rap1-associating GEF-1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001099624.3NP_001093094.2  rap guanine nucleotide exchange factor 2 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK147368, BC067056, BP758717
      Consensus CDS
      CCDS50932.1
      UniProtKB/TrEMBL
      E9QNQ4, Q6NXI4
      Related
      ENSMUSP00000113778.2, ENSMUST00000118340.7
      Conserved Domains (5) summary
      smart00100
      Location:134249
      cNMP; Cyclic nucleotide-monophosphate binding domain
      smart00229
      Location:265378
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00155
      Location:711936
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:382462
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cl00155
      Location:604688
      UBQ; Ubiquitin-like proteins
    2. NM_001310536.2NP_001297465.2  rap guanine nucleotide exchange factor 2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream in-frame start site compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.
      Source sequence(s)
      AC124358, AC164560
      Consensus CDS
      CCDS89637.1
      Related
      ENSMUSP00000114119.2, ENSMUST00000118100.8
      Conserved Domains (7) summary
      smart00100
      Location:136251
      cNMP; Cyclic nucleotide-monophosphate binding domain
      smart00229
      Location:267380
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      PHA03379
      Location:13611482
      PHA03379; EBNA-3A; Provisional
      cd00155
      Location:713938
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:384464
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      TIGR02037
      Location:404528
      degP_htrA_DO; periplasmic serine protease, Do/DeqQ family
      cd01785
      Location:608690
      RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      78969818..79194681 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006502250.5XP_006502313.1  rap guanine nucleotide exchange factor 2 isoform X2

      Conserved Domains (8) summary
      smart00100
      Location:291406
      cNMP; Cyclic nucleotide-monophosphate binding domain
      smart00229
      Location:422535
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      PHA03379
      Location:15161637
      PHA03379; EBNA-3A; Provisional
      cd00038
      Location:37143
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd00155
      Location:8681093
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:539619
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      TIGR02037
      Location:559683
      degP_htrA_DO; periplasmic serine protease, Do/DeqQ family
      cd01785
      Location:763845
      RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins
    2. XM_011240277.4XP_011238579.1  rap guanine nucleotide exchange factor 2 isoform X3

      Conserved Domains (8) summary
      smart00100
      Location:297412
      cNMP; Cyclic nucleotide-monophosphate binding domain
      smart00229
      Location:428541
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      PHA03379
      Location:15141635
      PHA03379; EBNA-3A; Provisional
      cd00038
      Location:37143
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd00155
      Location:8741078
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:545625
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      TIGR02037
      Location:565689
      degP_htrA_DO; periplasmic serine protease, Do/DeqQ family
      cd01785
      Location:769851
      RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins
    3. XM_011240276.4XP_011238578.1  rap guanine nucleotide exchange factor 2 isoform X1

      Related
      ENSMUSP00000141542.2, ENSMUST00000195708.2
      Conserved Domains (8) summary
      smart00100
      Location:297412
      cNMP; Cyclic nucleotide-monophosphate binding domain
      smart00229
      Location:428541
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      PHA03379
      Location:15221643
      PHA03379; EBNA-3A; Provisional
      cd00038
      Location:37143
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd00155
      Location:8741099
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:545625
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      TIGR02037
      Location:565689
      degP_htrA_DO; periplasmic serine protease, Do/DeqQ family
      cd01785
      Location:769851
      RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins
    4. XM_036163389.1XP_036019282.1  rap guanine nucleotide exchange factor 2 isoform X5

      Conserved Domains (6) summary
      smart00100
      Location:175290
      cNMP; Cyclic nucleotide-monophosphate binding domain
      smart00229
      Location:306419
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      PHA03379
      Location:14001521
      PHA03379; EBNA-3A; Provisional
      cd00155
      Location:752977
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:423503
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01785
      Location:647729
      RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins
    5. XM_006502252.5XP_006502315.1  rap guanine nucleotide exchange factor 2 isoform X4

      Conserved Domains (7) summary
      smart00100
      Location:181296
      cNMP; Cyclic nucleotide-monophosphate binding domain
      smart00229
      Location:312425
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      PHA03379
      Location:14061527
      PHA03379; EBNA-3A; Provisional
      cd00155
      Location:758983
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:429509
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      TIGR02037
      Location:449573
      degP_htrA_DO; periplasmic serine protease, Do/DeqQ family
      cd01785
      Location:653735
      RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins
    6. XM_030252869.2XP_030108729.1  rap guanine nucleotide exchange factor 2 isoform X6

      Conserved Domains (7) summary
      smart00100
      Location:117232
      cNMP; Cyclic nucleotide-monophosphate binding domain
      smart00229
      Location:248361
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      PHA03379
      Location:13421463
      PHA03379; EBNA-3A; Provisional
      cd00155
      Location:694919
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:365445
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      TIGR02037
      Location:385509
      degP_htrA_DO; periplasmic serine protease, Do/DeqQ family
      cd01785
      Location:589671
      RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins
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