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    Oga O-GlcNAcase [ Mus musculus (house mouse) ]

    Gene ID: 76055, updated on 18-Sep-2024

    Summary

    Official Symbol
    Ogaprovided by MGI
    Official Full Name
    O-GlcNAcaseprovided by MGI
    Primary source
    MGI:MGI:1932139
    See related
    Ensembl:ENSMUSG00000025220 AllianceGenome:MGI:1932139
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hy5; Mgea5; Ncoat
    Summary
    Predicted to enable beta-N-acetylglucosaminidase activity and histone acetyltransferase activity. Predicted to be involved in several processes, including positive regulation of mitochondrial depolarization; positive regulation of transport; and regulation of cellular protein metabolic process. Predicted to be located in cytosol and mitochondrion. Is expressed in brain ventricular layer; retina inner nuclear layer; retina nuclear layer; and retina outer nuclear layer. Orthologous to human OGA (O-GlcNAcase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 28.1), CNS E11.5 (RPKM 27.8) and 26 other tissues See more
    Orthologs
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    Genomic context

    See Oga in Genome Data Viewer
    Location:
    19 C3; 19 38.75 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (45738698..45772274, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (45750255..45783644, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene Fgf8 enhancer CR1 Neighboring gene STARR-positive B cell enhancer ABC_E11033 Neighboring gene fibroblast growth factor 8 Neighboring gene nucleoplasmin 3 Neighboring gene STARR-positive B cell enhancer ABC_E4286 Neighboring gene STARR-seq mESC enhancer starr_46285 Neighboring gene Kv channel-interacting protein 2 Neighboring gene STARR-seq mESC enhancer starr_46286 Neighboring gene armadillo-like helical domain containing 3 Neighboring gene STARR-positive B cell enhancer ABC_E7665 Neighboring gene ribosomal protein L21 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 
    • Targeted (5)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • mKIAA0679, 2810009A20Rik, 4833427O07Rik, 5830447M11Rik

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in N-acetylglucosamine metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in N-acetylglucosamine metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in dATP metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in glycoprotein metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of cardiac muscle adaptation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein glycosylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of D-glucose import ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of calcium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of calcium ion transport into cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell killing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of growth hormone secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of insulin secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of mitochondrial depolarization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein-containing complex disassembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of proteolysis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein deglycosylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein deglycosylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein targeting to membrane ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    protein O-GlcNAcase
    Names
    N-acetyl-beta-D-glucosaminidase
    N-acetyl-beta-glucosaminidase
    beta-N-acetylhexosaminidase
    beta-hexosaminidase
    bifunctional protein NCOAT
    meningioma expressed antigen 5 (hyaluronidase)
    meningioma-expressed antigen 5
    nuclear cytoplasmic O-GlcNAcase and acetyltransferase
    NP_001390278.1
    NP_001390280.1
    NP_001390281.1
    NP_001390282.1
    NP_076288.1
    XP_017173794.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001403349.1NP_001390278.1  protein O-GlcNAcase isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC149086
    2. NM_001403351.1NP_001390280.1  protein O-GlcNAcase isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC149086
    3. NM_001403352.1NP_001390281.1  protein O-GlcNAcase isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC149086
    4. NM_001403353.1NP_001390282.1  protein O-GlcNAcase isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC149086
    5. NM_023799.5NP_076288.1  protein O-GlcNAcase isoform 1

      See identical proteins and their annotated locations for NP_076288.1

      Status: VALIDATED

      Source sequence(s)
      AC149086
      Consensus CDS
      CCDS29866.1
      UniProtKB/Swiss-Prot
      Q3ULY7, Q6ZQ71, Q8BK05, Q8BTT2, Q8CFX2, Q9CSJ4, Q9CUR7, Q9EQQ9
      Related
      ENSMUSP00000026243.4, ENSMUST00000026243.5
      Conserved Domains (1) summary
      pfam07555
      Location:62338
      NAGidase; beta-N-acetylglucosaminidase

    RNA

    1. NR_151594.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC149086

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      45738698..45772274 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017318305.3XP_017173794.2  protein O-GlcNAcase isoform X2

      UniProtKB/TrEMBL
      Q05CX1
      Conserved Domains (1) summary
      pfam07555
      Location:100376
      NAGidase; beta-N-acetylglucosaminidase

    RNA

    1. XR_004940181.1 RNA Sequence