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    Oga O-GlcNAcase [ Mus musculus (house mouse) ]

    Gene ID: 76055, updated on 4-Sep-2021

    Summary

    Official Symbol
    Ogaprovided by MGI
    Official Full Name
    O-GlcNAcaseprovided by MGI
    Primary source
    MGI:MGI:1932139
    See related
    Ensembl:ENSMUSG00000025220
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hy5; Mgea; Mgea5; Ncoat
    Expression
    Ubiquitous expression in CNS E18 (RPKM 28.1), CNS E11.5 (RPKM 27.8) and 26 other tissues See more
    Orthologs
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    Genomic context

    See Oga in Genome Data Viewer
    Location:
    19 C3; 19 38.75 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (45738694..45772274, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (45750255..45783644, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (45824749..45857781, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene Fgf8 enhancer CR1 Neighboring gene fibroblast growth factor 8 Neighboring gene nucleoplasmin 3 Neighboring gene Kv channel-interacting protein 2 Neighboring gene armadillo-like helical domain containing 3 Neighboring gene ribosomal protein L21 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • mKIAA0679, 2810009A20Rik, 4833427O07Rik, 5830447M11Rik

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in N-acetylglucosamine metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in dATP metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in glycoprotein metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in necrotic cell death ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cardiac muscle adaptation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein glycosylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of calcium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of calcium ion transport into cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell killing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of glucose import ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of growth hormone secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of insulin secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of mitochondrial depolarization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein-containing complex disassembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of proteolysis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein deglycosylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein targeting to membrane ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    protein O-GlcNAcase
    Names
    N-acetyl-beta-D-glucosaminidase
    N-acetyl-beta-glucosaminidase
    beta-N-acetylhexosaminidase
    beta-hexosaminidase
    bifunctional protein NCOAT
    meningioma expressed antigen 5 (hyaluronidase)
    meningioma-expressed antigen 5
    nuclear cytoplasmic O-GlcNAcase and acetyltransferase
    NP_076288.1
    XP_017173794.2
    XP_036017614.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_023799.4NP_076288.1  protein O-GlcNAcase

      See identical proteins and their annotated locations for NP_076288.1

      Status: VALIDATED

      Source sequence(s)
      AC149086
      Consensus CDS
      CCDS29866.1
      UniProtKB/Swiss-Prot
      Q9EQQ9
      Related
      ENSMUSP00000026243.4, ENSMUST00000026243.5
      Conserved Domains (1) summary
      pfam07555
      Location:62338
      NAGidase; beta-N-acetylglucosaminidase

    RNA

    1. NR_151594.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC149086

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      45738694..45772274 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036161721.1XP_036017614.1  protein O-GlcNAcase isoform X1

      Conserved Domains (1) summary
      pfam07555
      Location:100376
      NAGidase; beta-N-acetylglucosaminidase
    2. XM_017318305.3XP_017173794.2  protein O-GlcNAcase isoform X2

      Conserved Domains (1) summary
      pfam07555
      Location:100376
      NAGidase; beta-N-acetylglucosaminidase

    RNA

    1. XR_004940181.1 RNA Sequence

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