U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Ncapg2 non-SMC condensin II complex, subunit G2 [ Mus musculus (house mouse) ]

    Gene ID: 76044, updated on 2-Nov-2024

    Summary

    Official Symbol
    Ncapg2provided by MGI
    Official Full Name
    non-SMC condensin II complex, subunit G2provided by MGI
    Primary source
    MGI:MGI:1923294
    See related
    Ensembl:ENSMUSG00000042029 AllianceGenome:MGI:1923294
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mtb; Luzp5; CAP-G2; mCAP-G2; 5830426I05Rik
    Summary
    Enables bHLH transcription factor binding activity. Involved in positive regulation of chromosome segregation and positive regulation of chromosome separation. Acts upstream of with a positive effect on erythrocyte differentiation. Acts upstream of with a negative effect on transcription by RNA polymerase II. Acts upstream of or within inner cell mass cell proliferation. Located in condensed nuclear chromosome. Part of condensin complex. Is active in nucleus. Is expressed in several structures, including axial musculature; brain; hemolymphoid system; liver; and nasal cavity epithelium. Orthologous to human NCAPG2 (non-SMC condensin II complex subunit G2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in liver E14 (RPKM 10.5), liver E14.5 (RPKM 8.0) and 13 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Ncapg2 in Genome Data Viewer
    Location:
    12 F2; 12 62.65 cM
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (116368969..116427152)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (116405351..116463532)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene extended synaptotagmin-like protein 2 Neighboring gene RIKEN cDNA 2310058N22 gene Neighboring gene RIKEN cDNA D430020J02 gene Neighboring gene STARR-positive B cell enhancer ABC_E4047 Neighboring gene STARR-seq mESC enhancer starr_33404 Neighboring gene U7 small nuclear RNA, pseudogene 1 Neighboring gene predicted gene, 25112

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables bHLH transcription factor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables methylated histone binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables methylated histone binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in condensed nuclear chromosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of condensin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of condensin complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of condensin complex NAS
    Non-traceable Author Statement
    more info
    PubMed 
    part_of condensin complex TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    condensin-2 complex subunit G2
    Names
    chromosome-associated protein G2
    leucine zipper protein 5
    more than blood protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133762.4NP_598523.3  condensin-2 complex subunit G2

      See identical proteins and their annotated locations for NP_598523.3

      Status: VALIDATED

      Source sequence(s)
      AC160634, AK081647, AK138871, AK139749, BB700949, BC076631, CK636577
      Consensus CDS
      CCDS26212.1
      UniProtKB/Swiss-Prot
      E9QP71, Q6DFV1, Q6SLL0, Q922D1
      Related
      ENSMUSP00000081889.4, ENSMUST00000084828.5
      Conserved Domains (2) summary
      sd00044
      Location:376404
      HEAT; HEAT repeat [structural motif]
      pfam12422
      Location:213360
      Condensin2nSMC; Condensin II non structural maintenance of chromosomes subunit

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      116368969..116427152
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036157652.1XP_036013545.1  condensin-2 complex subunit G2 isoform X1

      UniProtKB/Swiss-Prot
      E9QP71, Q6DFV1, Q6SLL0, Q922D1
      Conserved Domains (2) summary
      sd00044
      Location:376404
      HEAT; HEAT repeat [structural motif]
      pfam12422
      Location:213360
      Condensin2nSMC; Condensin II non structural maintenance of chromosomes subunit
    2. XM_036157653.1XP_036013546.1  condensin-2 complex subunit G2 isoform X2

      Conserved Domains (1) summary
      pfam12422
      Location:213360
      Condensin2nSMC; Condensin II non structural maintenance of chromosomes subunit
    3. XM_006516356.2XP_006516419.1  condensin-2 complex subunit G2 isoform X3

      Conserved Domains (2) summary
      sd00044
      Location:296324
      HEAT; HEAT repeat [structural motif]
      pfam12422
      Location:132280
      Condensin2nSMC; Condensin II non structural maintenance of chromosomes subunit
    4. XM_006516350.5XP_006516413.1  condensin-2 complex subunit G2 isoform X1

      See identical proteins and their annotated locations for XP_006516413.1

      UniProtKB/Swiss-Prot
      E9QP71, Q6DFV1, Q6SLL0, Q922D1
      Conserved Domains (2) summary
      sd00044
      Location:376404
      HEAT; HEAT repeat [structural motif]
      pfam12422
      Location:213360
      Condensin2nSMC; Condensin II non structural maintenance of chromosomes subunit
    5. XM_006516352.5XP_006516415.1  condensin-2 complex subunit G2 isoform X1

      See identical proteins and their annotated locations for XP_006516415.1

      UniProtKB/Swiss-Prot
      E9QP71, Q6DFV1, Q6SLL0, Q922D1
      Conserved Domains (2) summary
      sd00044
      Location:376404
      HEAT; HEAT repeat [structural motif]
      pfam12422
      Location:213360
      Condensin2nSMC; Condensin II non structural maintenance of chromosomes subunit
    6. XM_006516351.5XP_006516414.1  condensin-2 complex subunit G2 isoform X1

      See identical proteins and their annotated locations for XP_006516414.1

      UniProtKB/Swiss-Prot
      E9QP71, Q6DFV1, Q6SLL0, Q922D1
      Conserved Domains (2) summary
      sd00044
      Location:376404
      HEAT; HEAT repeat [structural motif]
      pfam12422
      Location:213360
      Condensin2nSMC; Condensin II non structural maintenance of chromosomes subunit
    7. XM_006516354.5XP_006516417.1  condensin-2 complex subunit G2 isoform X1

      See identical proteins and their annotated locations for XP_006516417.1

      UniProtKB/Swiss-Prot
      E9QP71, Q6DFV1, Q6SLL0, Q922D1
      Conserved Domains (2) summary
      sd00044
      Location:376404
      HEAT; HEAT repeat [structural motif]
      pfam12422
      Location:213360
      Condensin2nSMC; Condensin II non structural maintenance of chromosomes subunit
    8. XM_006516353.4XP_006516416.1  condensin-2 complex subunit G2 isoform X1

      See identical proteins and their annotated locations for XP_006516416.1

      UniProtKB/Swiss-Prot
      E9QP71, Q6DFV1, Q6SLL0, Q922D1
      Conserved Domains (2) summary
      sd00044
      Location:376404
      HEAT; HEAT repeat [structural motif]
      pfam12422
      Location:213360
      Condensin2nSMC; Condensin II non structural maintenance of chromosomes subunit