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    Nln neurolysin (metallopeptidase M3 family) [ Mus musculus (house mouse) ]

    Gene ID: 75805, updated on 23-Jun-2021

    Summary

    Official Symbol
    Nlnprovided by MGI
    Official Full Name
    neurolysin (metallopeptidase M3 family)provided by MGI
    Primary source
    MGI:MGI:1923055
    See related
    Ensembl:ENSMUSG00000021710
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C79345; 4930472G13Rik
    Expression
    Ubiquitous expression in CNS E18 (RPKM 12.4), whole brain E14.5 (RPKM 7.3) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Nln in Genome Data Viewer
    Location:
    13; 13 D1
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (104159558..104246170, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (104023050..104109673, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (104813519..104899694, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene splicing regulatory glutamine/lysine-rich protein 1 Neighboring gene predicted gene, 52054 Neighboring gene Erbb2 interacting protein Neighboring gene RIKEN cDNA D130037M23 gene Neighboring gene predicted gene, 30967 Neighboring gene small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta Neighboring gene trafficking protein particle complex 13 Neighboring gene shieldin complex subunit 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (2) 

    Pathways from PubChem

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables metalloendopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables oligopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables peptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables peptide binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in peptide metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in proteolysis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of gluconeogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of skeletal muscle fiber differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in mitochondrial intermembrane space IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in mitochondrial intermembrane space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion HDA PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    neurolysin, mitochondrial
    Names
    MEP
    microsomal endopeptidase
    mitochondrial oligopeptidase M
    neurotensin endopeptidase
    NP_083723.1
    XP_011243001.1
    XP_011243002.1
    XP_011243003.1
    XP_030103312.1
    XP_036014106.1
    XP_036014107.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029447.2NP_083723.1  neurolysin, mitochondrial precursor

      See identical proteins and their annotated locations for NP_083723.1

      Status: PROVISIONAL

      Source sequence(s)
      AK079090
      Consensus CDS
      CCDS36772.1
      UniProtKB/Swiss-Prot
      Q91YP2
      Related
      ENSMUSP00000104938.4, ENSMUST00000109315.5
      Conserved Domains (2) summary
      cd06455
      Location:60699
      M3A_TOP; Peptidase M3 Thimet oligopeptidase (TOP) also includes neurolysin
      COG0339
      Location:54703
      Dcp; Zn-dependent oligopeptidase [Posttranslational modification, protein turnover, chaperones]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      104159558..104246170 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011244699.3XP_011243001.1  neurolysin, mitochondrial isoform X1

      Conserved Domains (1) summary
      cd09605
      Location:58741
      M3A; Peptidase M3A family includes thimet oligopeptidase, dipeptidyl carboxypeptidase and mitochondrial intermediate peptidase
    2. XM_011244700.2XP_011243002.1  neurolysin, mitochondrial isoform X2

      See identical proteins and their annotated locations for XP_011243002.1

      Conserved Domains (1) summary
      cd09605
      Location:35718
      M3A; Peptidase M3A family includes thimet oligopeptidase, dipeptidyl carboxypeptidase and mitochondrial intermediate peptidase
    3. XM_011244701.3XP_011243003.1  neurolysin, mitochondrial isoform X2

      See identical proteins and their annotated locations for XP_011243003.1

      Conserved Domains (1) summary
      cd09605
      Location:35718
      M3A; Peptidase M3A family includes thimet oligopeptidase, dipeptidyl carboxypeptidase and mitochondrial intermediate peptidase
    4. XM_036158213.1XP_036014106.1  neurolysin, mitochondrial isoform X2

      Conserved Domains (1) summary
      cd09605
      Location:35718
      M3A; Peptidase M3A family includes thimet oligopeptidase, dipeptidyl carboxypeptidase and mitochondrial intermediate peptidase
    5. XM_036158214.1XP_036014107.1  neurolysin, mitochondrial isoform X3

      Conserved Domains (1) summary
      cd09605
      Location:35676
      M3A; Peptidase M3A family includes thimet oligopeptidase, dipeptidyl carboxypeptidase and mitochondrial intermediate peptidase
    6. XM_030247452.2XP_030103312.1  neurolysin, mitochondrial isoform X3

      Conserved Domains (1) summary
      cd09605
      Location:35676
      M3A; Peptidase M3A family includes thimet oligopeptidase, dipeptidyl carboxypeptidase and mitochondrial intermediate peptidase

    RNA

    1. XR_873797.4 RNA Sequence

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