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    MPPED1 metallophosphoesterase domain containing 1 [ Homo sapiens (human) ]

    Gene ID: 758, updated on 5-Mar-2024

    Summary

    Official Symbol
    MPPED1provided by HGNC
    Official Full Name
    metallophosphoesterase domain containing 1provided by HGNC
    Primary source
    HGNC:HGNC:1306
    See related
    Ensembl:ENSG00000186732 MIM:602112; AllianceGenome:HGNC:1306
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    239AB; FAM1A; C22orf1
    Summary
    Predicted to enable hydrolase activity. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in brain (RPKM 6.2) and liver (RPKM 1.2) See more
    Orthologs
    NEW
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    Genomic context

    Location:
    22q13.2
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (43412014..43507848)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (43893098..43990288)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (43808020..43903728)

    Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373053 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:43784068-43784646 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:43784647-43785225 Neighboring gene long intergenic non-protein coding RNA 1639 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:43823805-43824306 Neighboring gene MPRA-validated peak4505 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:43860857-43861358 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:43883837-43884610 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:43883063-43883836 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:43910482-43911240 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:43923573-43924072 Neighboring gene EFCAB6 antisense RNA 1 Neighboring gene NANOG hESC enhancer GRCh37_chr22:43932755-43933256 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:43938541-43939320 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:43939321-43940098 Neighboring gene EF-hand calcium binding domain 6 Neighboring gene uncharacterized LOC101927474 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:43966769-43967269

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ50009, FLJ54633, FLJ59965, FLJ78907, MGC88045

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
     
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
     

    General protein information

    Preferred Names
    metallophosphoesterase domain-containing protein 1
    Names
    adult brain protein 239

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001044370.2NP_001037835.1  metallophosphoesterase domain-containing protein 1 precursor

      See identical proteins and their annotated locations for NP_001037835.1

      Status: VALIDATED

      Source sequence(s)
      BC028035, BX546033, DA773758, U84894
      Consensus CDS
      CCDS46723.1
      UniProtKB/Swiss-Prot
      A8K159, B7Z2S9, O15442, Q8N361
      UniProtKB/TrEMBL
      B7Z9P3
      Related
      ENSP00000400686.1, ENST00000443721.2
      Conserved Domains (1) summary
      cd07379
      Location:91303
      MPP_239FB; Homo sapiens 239FB and related proteins, metallophosphatase domain
    2. NM_001362786.2NP_001349715.1  metallophosphoesterase domain-containing protein 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AK294912, BC028035, BI915267, BX546033, FP325334
      Consensus CDS
      CCDS46723.1
      UniProtKB/Swiss-Prot
      A8K159, B7Z2S9, O15442, Q8N361
      UniProtKB/TrEMBL
      B7Z9P3
      Conserved Domains (1) summary
      cd07379
      Location:91303
      MPP_239FB; Homo sapiens 239FB and related proteins, metallophosphatase domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

      Range
      43412014..43507848
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060946.1 Alternate T2T-CHM13v2.0

      Range
      43893098..43990288
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)