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    Ckap5 cytoskeleton associated protein 5 [ Mus musculus (house mouse) ]

    Gene ID: 75786, updated on 8-Jul-2021

    Summary

    Official Symbol
    Ckap5provided by MGI
    Official Full Name
    cytoskeleton associated protein 5provided by MGI
    Primary source
    MGI:MGI:1923036
    See related
    Ensembl:ENSMUSG00000040549
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    T25636; mKIAA0097; 3110043H24Rik; 4930432B04Rik; D730027C18Rik
    Expression
    Broad expression in CNS E11.5 (RPKM 33.2), CNS E14 (RPKM 22.3) and 21 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Ckap5 in Genome Data Viewer
    Location:
    2; 2 E1
    Exon count:
    47
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (91357092..91451024)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (91526747..91620679)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (91386479..91460822)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene low density lipoprotein receptor-related protein 4 Neighboring gene predicted gene 13770 Neighboring gene small nucleolar RNA, C/D box 67 Neighboring gene coagulation factor II Neighboring gene cytochrome c oxidase subunit 7B, mitochondrial pseudogene Neighboring gene zinc finger protein 408

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables microtubule plus end polymerase IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ribonucleoprotein complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within central nervous system myelin formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within centrosome cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in centrosome duplication IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of cytoplasmic translation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within cytoplasmic translation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within dendritic spine maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in establishment or maintenance of microtubule cytoskeleton polarity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in establishment or maintenance of microtubule cytoskeleton polarity ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within excitatory postsynaptic potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within habituation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within long-term synaptic potentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within mRNA localization resulting in posttranscriptional regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in microtubule polymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in mitotic spindle organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of microtubule nucleation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within ribonucleoprotein complex assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within ribonucleoprotein complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in spindle organization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within visual learning IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in kinetochore ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with microtubule plus-end IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    colocalizes_with microtubule plus-end ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal ribonucleoprotein granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perikaryon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    is_active_in spindle pole IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in spindle pole ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    cytoskeleton-associated protein 5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001165989.2NP_001159461.1  cytoskeleton-associated protein 5 isoform 1

      See identical proteins and their annotated locations for NP_001159461.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AL691489
      Consensus CDS
      CCDS50640.1
      UniProtKB/TrEMBL
      K3W4R5
      Related
      ENSMUSP00000106970.4, ENSMUST00000111338.10
      Conserved Domains (1) summary
      pfam12348
      Location:8561048
      CLASP_N; CLASP N terminal
    2. NM_029437.2NP_083713.2  cytoskeleton-associated protein 5 isoform 2

      See identical proteins and their annotated locations for NP_083713.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      BC089032, BC096422
      Consensus CDS
      CCDS16433.1
      UniProtKB/Swiss-Prot
      A2AGT5
      UniProtKB/TrEMBL
      A0A0R4J0K2
      Related
      ENSMUSP00000046263.10, ENSMUST00000046769.16
      Conserved Domains (1) summary
      pfam12348
      Location:8561048
      CLASP_N; CLASP N terminal

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      91357092..91451024
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006500342.1XP_006500405.1  cytoskeleton-associated protein 5 isoform X1

      See identical proteins and their annotated locations for XP_006500405.1

      Conserved Domains (1) summary
      pfam12348
      Location:8561048
      CLASP_N; CLASP N terminal
    2. XM_030252170.1XP_030108030.1  cytoskeleton-associated protein 5 isoform X1

    3. XM_036162654.1XP_036018547.1  cytoskeleton-associated protein 5 isoform X2

    4. XM_006500343.4XP_006500406.1  cytoskeleton-associated protein 5 isoform X1

      See identical proteins and their annotated locations for XP_006500406.1

      Conserved Domains (1) summary
      pfam12348
      Location:8561048
      CLASP_N; CLASP N terminal
    5. XM_036162653.1XP_036018546.1  cytoskeleton-associated protein 5 isoform X2

    6. XM_030252169.2XP_030108029.1  cytoskeleton-associated protein 5 isoform X1

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