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    Ipo4 importin 4 [ Mus musculus (house mouse) ]

    Gene ID: 75751, updated on 23-Jun-2021

    Summary

    Official Symbol
    Ipo4provided by MGI
    Official Full Name
    importin 4provided by MGI
    Primary source
    MGI:MGI:1923001
    See related
    Ensembl:ENSMUSG00000002319
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Imp4a; RanBP4; AA409693; 8430408O15Rik
    Expression
    Ubiquitous expression in testis adult (RPKM 123.0), ovary adult (RPKM 46.1) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Ipo4 in Genome Data Viewer
    Location:
    14 C3; 14 28.19 cM
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (55862857..55873321, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (55625400..55635868, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (56244466..56254515, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene interferon regulatory factor 9 Neighboring gene REC8 meiotic recombination protein Neighboring gene transmembrane 9 superfamily member 1 Neighboring gene testis-specific serine kinase 4 Neighboring gene magnesium-dependent phosphatase 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC113723

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables nuclear import signal receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables nuclear localization sequence binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in DNA replication-dependent nucleosome assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in DNA replication-independent nucleosome assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within ribosome biogenesis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    importin-4
    Names
    imp4
    importin 4a
    ran-binding protein 4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360078.1NP_001347007.1  importin-4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AK030490, AK147086, BM950244
      Conserved Domains (3) summary
      smart00913
      Location:2490
      IBN_N; Importin-beta N-terminal domain
      COG5215
      Location:353620
      KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
      sd00044
      Location:353381
      HEAT; HEAT repeat [structural motif]
    2. NM_024267.7NP_077229.4  importin-4 isoform 1

      See identical proteins and their annotated locations for NP_077229.4

      Status: VALIDATED

      Source sequence(s)
      AK030490, AK147086
      Consensus CDS
      CCDS27121.1
      UniProtKB/Swiss-Prot
      Q8VI75
      Related
      ENSMUSP00000036555.10, ENSMUST00000047131.16
      Conserved Domains (2) summary
      smart00913
      Location:2490
      IBN_N; Importin-beta N-terminal domain
      sd00044
      Location:353381
      HEAT; HEAT repeat [structural motif]

    RNA

    1. NR_153401.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AK030490, AK147086, BC085150
      Related
      ENSMUST00000135221.8
    2. NR_153402.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AK018399, AK030490, AK147086
      Related
      ENSMUST00000148351.8

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      55862857..55873321 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017316220.3XP_017171709.1  importin-4 isoform X1

      Conserved Domains (2) summary
      COG5215
      Location:153420
      KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
      sd00044
      Location:153181
      HEAT; HEAT repeat [structural motif]
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