Format

Send to:

Choose Destination
    • Showing Current items.

    Sesn3 sestrin 3 [ Mus musculus (house mouse) ]

    Gene ID: 75747, updated on 6-Jul-2021

    Summary

    Official Symbol
    Sesn3provided by MGI
    Official Full Name
    sestrin 3provided by MGI
    Primary source
    MGI:MGI:1922997
    See related
    Ensembl:ENSMUSG00000032009
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SES; SEST3; BC003348; 5630400E15Rik
    Expression
    Ubiquitous expression in ovary adult (RPKM 13.1), thymus adult (RPKM 11.0) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Sesn3 in Genome Data Viewer
    Location:
    9; 9 A1
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (14187597..14237430)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (14276301..14326134)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (14080745..14130578)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene microRNA 12204 Neighboring gene predicted gene, 34069 Neighboring gene endonuclease domain containing 1 Neighboring gene predicted gene, 34156 Neighboring gene lysine (K)-specific demethylase 4D-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    General gene information

    Markers

    Homology

    Clone Names

    • MGC7182

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables leucine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables oxidoreductase activity, acting on peroxide as acceptor IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in TORC2 signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to amino acid starvation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to amino acid stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to glucose starvation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to leucine IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cellular response to leucine starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within glucose homeostasis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in glucose homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of TORC1 signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in negative regulation of TORC1 signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of TORC1 signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of macroautophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of insulin receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of protein kinase B signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of response to reactive oxygen species IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within response to insulin IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in response to insulin IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of GATOR2 complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of TORC2 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_030261.4NP_084537.2  sestrin-3

      See identical proteins and their annotated locations for NP_084537.2

      Status: PROVISIONAL

      Source sequence(s)
      AK155398
      Consensus CDS
      CCDS22820.1
      UniProtKB/Swiss-Prot
      Q9CYP7
      UniProtKB/TrEMBL
      A2RSF4
      Related
      ENSMUSP00000146362.2, ENSMUST00000208222.2
      Conserved Domains (1) summary
      pfam04636
      Location:39490
      PA26; PA26 p53-induced protein (sestrin)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      14187597..14237430
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center