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    Mff mitochondrial fission factor [ Mus musculus (house mouse) ]

    Gene ID: 75734, updated on 3-Jul-2021

    Summary

    Official Symbol
    Mffprovided by MGI
    Official Full Name
    mitochondrial fission factorprovided by MGI
    Primary source
    MGI:MGI:1922984
    See related
    Ensembl:ENSMUSG00000026150
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AI314724; 5230400G24Rik
    Expression
    Ubiquitous expression in CNS E18 (RPKM 63.2), cerebellum adult (RPKM 48.6) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Mff in Genome Data Viewer
    Location:
    1; 1 C5
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (82702599..82730111)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (82724890..82752390)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (82721493..82748965)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene collagen, type IV, alpha 4 Neighboring gene collagen, type IV, alpha 3 Neighboring gene RIKEN cDNA C430014B12 gene Neighboring gene transmembrane 4 L six family member 20 Neighboring gene predicted gene, 19257

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in mitochondrial fission IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in mitochondrial fission IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mitochondrial fragmentation involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitochondrial fusion ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within mitochondrion morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peroxisome fission ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of mitochondrial fission IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of mitochondrial fission ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein targeting to membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of release of cytochrome c from mitochondria ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein targeting to mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein targeting to mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein targeting to mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of mitochondrion organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of peroxisome organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in release of cytochrome c from mitochondria ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in integral component of mitochondrial membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in integral component of mitochondrial outer membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrial outer membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in peroxisome ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    mitochondrial fission factor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001310695.1NP_001297624.1  mitochondrial fission factor isoform 2

      See identical proteins and their annotated locations for NP_001297624.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice junction and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AK017226, AU080386, BC059229
      Consensus CDS
      CCDS78630.1
      UniProtKB/Swiss-Prot
      Q6PCP5
      Related
      ENSMUSP00000072784.6, ENSMUST00000073025.12
      Conserved Domains (1) summary
      pfam05644
      Location:1239
      Miff; Mitochondrial and peroxisomal fission factor Mff
    2. NM_001310697.1NP_001297626.1  mitochondrial fission factor isoform 3

      See identical proteins and their annotated locations for NP_001297626.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AK139649, AU080386, BC059229
      Consensus CDS
      CCDS78631.1
      UniProtKB/Swiss-Prot
      Q6PCP5
      Related
      ENSMUSP00000125230.2, ENSMUST00000160786.8
      Conserved Domains (1) summary
      pfam05644
      Location:1238
      Miff; Mitochondrial and peroxisomal fission factor Mff
    3. NM_001310699.1NP_001297628.1  mitochondrial fission factor isoform 4

      See identical proteins and their annotated locations for NP_001297628.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (4) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC138214, AU080386, BC059229, CX231761
      Consensus CDS
      CCDS78632.1
      UniProtKB/Swiss-Prot
      Q6PCP5
      Related
      ENSMUSP00000124200.2, ENSMUST00000160972.8
      Conserved Domains (1) summary
      pfam05644
      Location:1218
      Miff; Mitochondrial and peroxisomal fission factor Mff
    4. NM_001372405.1NP_001359334.1  mitochondrial fission factor isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) represents the longest transcript and encodes the longest isoform (5).
      Source sequence(s)
      AC138214
      Conserved Domains (1) summary
      pfam05644
      Location:27317
      Miff; Mitochondrial and peroxisomal fission factor Mff
    5. NM_001372406.1NP_001359335.1  mitochondrial fission factor isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC138214
      Conserved Domains (1) summary
      pfam05644
      Location:1303
      Miff; Mitochondrial and peroxisomal fission factor Mff
    6. NM_001372407.1NP_001359336.1  mitochondrial fission factor isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC138214
      Conserved Domains (1) summary
      pfam05644
      Location:1302
      Miff; Mitochondrial and peroxisomal fission factor Mff
    7. NM_001372408.1NP_001359337.1  mitochondrial fission factor isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC138214
      Conserved Domains (1) summary
      pfam05644
      Location:1292
      Miff; Mitochondrial and peroxisomal fission factor Mff
    8. NM_001372409.1NP_001359338.1  mitochondrial fission factor isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC138214
      Conserved Domains (1) summary
      pfam05644
      Location:1272
      Miff; Mitochondrial and peroxisomal fission factor Mff
    9. NM_001372411.1NP_001359340.1  mitochondrial fission factor isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC138214
      Conserved Domains (1) summary
      pfam05644
      Location:1271
      Miff; Mitochondrial and peroxisomal fission factor Mff
    10. NM_001372412.1NP_001359341.1  mitochondrial fission factor isoform 11

      Status: VALIDATED

      Source sequence(s)
      AC138214
      Conserved Domains (1) summary
      pfam05644
      Location:1250
      Miff; Mitochondrial and peroxisomal fission factor Mff
    11. NM_001372413.1NP_001359342.1  mitochondrial fission factor isoform 12

      Status: VALIDATED

      Source sequence(s)
      AC138214
      Related
      ENSMUSP00000125223.2, ENSMUST00000160750.8
      Conserved Domains (1) summary
      pfam05644
      Location:1249
      Miff; Mitochondrial and peroxisomal fission factor Mff
    12. NM_001372414.1NP_001359343.1  mitochondrial fission factor isoform 13

      Status: VALIDATED

      Source sequence(s)
      AC138214
      Conserved Domains (1) summary
      pfam05644
      Location:1219
      Miff; Mitochondrial and peroxisomal fission factor Mff
    13. NM_029409.3NP_083685.2  mitochondrial fission factor isoform 1

      See identical proteins and their annotated locations for NP_083685.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AU080386, BC059229
      Consensus CDS
      CCDS15098.1
      UniProtKB/Swiss-Prot
      Q6PCP5
      Related
      ENSMUSP00000077446.7, ENSMUST00000078332.13
      Conserved Domains (1) summary
      pfam05644
      Location:1291
      Miff; Mitochondrial and peroxisomal fission factor Mff

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      82702599..82730111
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036154165.1XP_036010058.1  mitochondrial fission factor isoform X1

      Conserved Domains (1) summary
      pfam05644
      Location:27354
      Miff; Mitochondrial and peroxisomal fission factor Mff
    2. XM_036154176.1XP_036010069.1  mitochondrial fission factor isoform X3

      Conserved Domains (1) summary
      pfam05644
      Location:27343
      Miff; Mitochondrial and peroxisomal fission factor Mff
    3. XM_036154189.1XP_036010082.1  mitochondrial fission factor isoform X9

      Conserved Domains (1) summary
      pfam05644
      Location:27323
      Miff; Mitochondrial and peroxisomal fission factor Mff
    4. XM_006496556.4XP_006496619.1  mitochondrial fission factor isoform X5

      Conserved Domains (1) summary
      pfam05644
      Location:27329
      Miff; Mitochondrial and peroxisomal fission factor Mff
    5. XM_006496558.3XP_006496621.1  mitochondrial fission factor isoform X11

      Conserved Domains (1) summary
      pfam05644
      Location:27318
      Miff; Mitochondrial and peroxisomal fission factor Mff
    6. XM_006496562.4XP_006496625.1  mitochondrial fission factor isoform X14

      Conserved Domains (1) summary
      pfam05644
      Location:27298
      Miff; Mitochondrial and peroxisomal fission factor Mff
    7. XM_006496564.4XP_006496627.1  mitochondrial fission factor isoform X17

      Conserved Domains (1) summary
      pfam05644
      Location:27276
      Miff; Mitochondrial and peroxisomal fission factor Mff
    8. XM_006496566.5XP_006496629.1  mitochondrial fission factor isoform X19

      Conserved Domains (1) summary
      pfam05644
      Location:27265
      Miff; Mitochondrial and peroxisomal fission factor Mff
    9. XM_006496568.5XP_006496631.1  mitochondrial fission factor isoform X21

      Conserved Domains (1) summary
      pfam05644
      Location:27245
      Miff; Mitochondrial and peroxisomal fission factor Mff
    10. XM_036154172.1XP_036010065.1  mitochondrial fission factor isoform X2

      Conserved Domains (1) summary
      pfam05644
      Location:27353
      Miff; Mitochondrial and peroxisomal fission factor Mff
    11. XM_036154179.1XP_036010072.1  mitochondrial fission factor isoform X4

      Conserved Domains (1) summary
      pfam05644
      Location:27342
      Miff; Mitochondrial and peroxisomal fission factor Mff
    12. XM_036154191.1XP_036010084.1  mitochondrial fission factor isoform X10

      Conserved Domains (1) summary
      pfam05644
      Location:27322
      Miff; Mitochondrial and peroxisomal fission factor Mff
    13. XM_006496557.5XP_006496620.1  mitochondrial fission factor isoform X6

      Conserved Domains (1) summary
      pfam05644
      Location:27328
      Miff; Mitochondrial and peroxisomal fission factor Mff
    14. XM_006496563.5XP_006496626.1  mitochondrial fission factor isoform X15

      Conserved Domains (1) summary
      pfam05644
      Location:27297
      Miff; Mitochondrial and peroxisomal fission factor Mff
    15. XM_006496565.5XP_006496628.1  mitochondrial fission factor isoform X18

      Conserved Domains (1) summary
      pfam05644
      Location:27275
      Miff; Mitochondrial and peroxisomal fission factor Mff
    16. XM_006496567.5XP_006496630.1  mitochondrial fission factor isoform X20

      See identical proteins and their annotated locations for XP_006496630.1

      Conserved Domains (1) summary
      pfam05644
      Location:27264
      Miff; Mitochondrial and peroxisomal fission factor Mff
    17. XM_006496569.4XP_006496632.1  mitochondrial fission factor isoform X22

      Conserved Domains (1) summary
      pfam05644
      Location:27244
      Miff; Mitochondrial and peroxisomal fission factor Mff
    18. XM_036154185.1XP_036010078.1  mitochondrial fission factor isoform X7

      Conserved Domains (1) summary
      pfam05644
      Location:1328
      Miff; Mitochondrial and peroxisomal fission factor Mff
    19. XM_036154192.1XP_036010085.1  mitochondrial fission factor isoform X12

      Conserved Domains (1) summary
      pfam05644
      Location:1317
      Miff; Mitochondrial and peroxisomal fission factor Mff
    20. XM_036154187.1XP_036010080.1  mitochondrial fission factor isoform X8

      Conserved Domains (1) summary
      pfam05644
      Location:1327
      Miff; Mitochondrial and peroxisomal fission factor Mff
    21. XM_036154194.1XP_036010087.1  mitochondrial fission factor isoform X13

      Related
      ENSMUSP00000124334.2, ENSMUST00000162003.8
      Conserved Domains (1) summary
      pfam05644
      Location:1316
      Miff; Mitochondrial and peroxisomal fission factor Mff
    22. XM_036154199.1XP_036010092.1  mitochondrial fission factor isoform X16

      Conserved Domains (1) summary
      pfam05644
      Location:1296
      Miff; Mitochondrial and peroxisomal fission factor Mff
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