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    Ippk inositol 1,3,4,5,6-pentakisphosphate 2-kinase [ Mus musculus (house mouse) ]

    Gene ID: 75678, updated on 23-Jun-2021

    Summary

    Official Symbol
    Ippkprovided by MGI
    Official Full Name
    inositol 1,3,4,5,6-pentakisphosphate 2-kinaseprovided by MGI
    Primary source
    MGI:MGI:1922928
    See related
    Ensembl:ENSMUSG00000021385
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    InsP6; 1810043M15Rik
    Expression
    Ubiquitous expression in placenta adult (RPKM 15.4), testis adult (RPKM 4.6) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Ippk in Genome Data Viewer
    Location:
    13; 13 A5
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (49574673..49618050)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (49421198..49464574)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (49516680..49558359)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA E030007A22 gene Neighboring gene FYVE, RhoGEF and PH domain containing 3 Neighboring gene BICD cargo adaptor 2 Neighboring gene centromere protein P Neighboring gene testis derived transcript 3, pseudogene Neighboring gene extracellular matrix protein 2, female organ and adipocyte specific

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables inositol pentakisphosphate 2-kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables inositol pentakisphosphate 2-kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables molecular adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in inositol phosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in inositol phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in inositol phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of transcription of nucleolar large rRNA by RNA polymerase I ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    inositol-pentakisphosphate 2-kinase
    Names
    ins(1,3,4,5,6)P5 2-kinase
    insP5 2-kinase
    NP_001263328.1
    NP_951011.1
    XP_017171117.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001276399.2NP_001263328.1  inositol-pentakisphosphate 2-kinase isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate 5' exon and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (b) is longer and has a distinct N-terminus, compared to isoform a.
      Source sequence(s)
      AC123954
      Consensus CDS
      CCDS88452.1
      UniProtKB/TrEMBL
      A0A217FL54
      Related
      ENSMUSP00000021817.10, ENSMUST00000021817.10
      Conserved Domains (1) summary
      pfam06090
      Location:80504
      Ins_P5_2-kin; Inositol-pentakisphosphate 2-kinase
    2. NM_199056.4NP_951011.1  inositol-pentakisphosphate 2-kinase isoform a

      See identical proteins and their annotated locations for NP_951011.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shortest transcript and encodes the shorter isoform (a).
      Source sequence(s)
      AC123954
      Consensus CDS
      CCDS26500.1
      UniProtKB/Swiss-Prot
      Q6P1C1
      Related
      ENSMUSP00000152331.2, ENSMUST00000220447.2
      Conserved Domains (1) summary
      pfam06090
      Location:13455
      Ins_P5_2-kin; Inositol-pentakisphosphate 2-kinase

    RNA

    1. NR_075085.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate exon near the 5' end, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC123954, AK160092, AV306360, BB619387, CD353694, DV647168
      Related
      ENSMUST00000220856.2
    2. NR_165080.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC123954

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      49574673..49618050
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017315628.3XP_017171117.1  inositol-pentakisphosphate 2-kinase isoform X1

      Conserved Domains (1) summary
      pfam06090
      Location:13201
      Ins_P5_2-kin; Inositol-pentakisphosphate 2-kinase
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