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    Ippk inositol 1,3,4,5,6-pentakisphosphate 2-kinase [ Mus musculus (house mouse) ]

    Gene ID: 75678, updated on 2-Oct-2018

    Summary

    Official Symbol
    Ippkprovided by MGI
    Official Full Name
    inositol 1,3,4,5,6-pentakisphosphate 2-kinaseprovided by MGI
    Primary source
    MGI:MGI:1922928
    See related
    Ensembl:ENSMUSG00000021385
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    InsP6; 1810043M15Rik
    Expression
    Ubiquitous expression in placenta adult (RPKM 15.4), testis adult (RPKM 4.6) and 28 other tissues See more
    Orthologs

    Genomic context

    See Ippk in Genome Data Viewer
    Location:
    13; 13 A5
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 13 NC_000079.6 (49421190..49463060)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (49516680..49558359)

    Chromosome 13 - NC_000079.6Genomic Context describing neighboring genes Neighboring gene BICD cargo adaptor 2 Neighboring gene predicted gene, 46413 Neighboring gene centromere protein P Neighboring gene testis derived transcript 3, pseudogene Neighboring gene extracellular matrix protein 2, female organ and adipocyte specific

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    inositol pentakisphosphate 2-kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    inositol pentakisphosphate 2-kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein-containing complex scaffold activity ISO
    Inferred from Sequence Orthology
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    inositol phosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    inositol phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    inositol phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of transcription of nucleolar large rRNA by RNA polymerase I ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    inositol-pentakisphosphate 2-kinase
    Names
    ins(1,3,4,5,6)P5 2-kinase
    insP5 2-kinase
    NP_001263328.1
    NP_951011.1
    XP_017171117.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001276399.1NP_001263328.1  inositol-pentakisphosphate 2-kinase isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate 5' exon and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (b) is longer and has a distinct N-terminus, compared to isoform a.
      Source sequence(s)
      AK007761, AK031987, AV306360, CD353694
      UniProtKB/TrEMBL
      A0A217FL54
      Related
      ENSMUSP00000021817.9, ENSMUST00000021817.9
      Conserved Domains (1) summary
      pfam06090
      Location:80504
      Ins_P5_2-kin; Inositol-pentakisphosphate 2-kinase
    2. NM_199056.3NP_951011.1  inositol-pentakisphosphate 2-kinase isoform a

      See identical proteins and their annotated locations for NP_951011.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shortest transcript and encodes the shorter isoform (a).
      Source sequence(s)
      AC123954, AK167467, AV306360
      Consensus CDS
      CCDS26500.1
      UniProtKB/Swiss-Prot
      Q6P1C1
      Related
      ENSMUSP00000152331.1, ENSMUST00000220447.1
      Conserved Domains (1) summary
      pfam06090
      Location:13455
      Ins_P5_2-kin; Inositol-pentakisphosphate 2-kinase

    RNA

    1. NR_075085.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate exon near the 5' end, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC123954, AK160092, AV306360, BB619387, CD353694, DV647168
      Related
      ENSMUST00000220856.1

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000079.6 Reference GRCm38.p4 C57BL/6J

      Range
      49421190..49463060
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017315628.1XP_017171117.1  inositol-pentakisphosphate 2-kinase isoform X1

    RNA

    1. XR_001780827.1 RNA Sequence

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