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    Pik3r4 phosphoinositide-3-kinase regulatory subunit 4 [ Mus musculus (house mouse) ]

    Gene ID: 75669, updated on 5-Sep-2021

    Summary

    Official Symbol
    Pik3r4provided by MGI
    Official Full Name
    phosphoinositide-3-kinase regulatory subunit 4provided by MGI
    Primary source
    MGI:MGI:1922919
    See related
    Ensembl:ENSMUSG00000032571
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Vp; p15; p150; Vps15; C85833; D9Ertd418e; 2210010O15Rik; C730038E05Rik
    Expression
    Ubiquitous expression in ovary adult (RPKM 8.1), spleen adult (RPKM 7.8) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Pik3r4 in Genome Data Viewer
    Location:
    9 F1; 9 56.79 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (105520156..105564854)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (105642995..105687655)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (105545325..105589985)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene ubiquinol-cytochrome c reductase complex assembly factor 2 pseudogene Neighboring gene predicted gene 5621 Neighboring gene predicted gene, 22720 Neighboring gene collagen, type VI, alpha 6 Neighboring gene collagen, type VI, alpha 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in autophagy of peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cellular response to glucose starvation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in late endosome to vacuole transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in macroautophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of phosphatidylinositol 3-kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein targeting to vacuole IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in receptor catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cytokinesis ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in axoneme IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in late endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in late endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus-vacuole junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of phosphatidylinositol 3-kinase complex, class III IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of phosphatidylinositol 3-kinase complex, class III, type I IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of phosphatidylinositol 3-kinase complex, class III, type II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    phosphoinositide 3-kinase regulatory subunit 4
    Names
    PI3-kinase regulatory subunit 4
    phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 4, p150
    NP_001074778.1
    XP_036011263.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081309.1NP_001074778.1  phosphoinositide 3-kinase regulatory subunit 4

      See identical proteins and their annotated locations for NP_001074778.1

      Status: PROVISIONAL

      Source sequence(s)
      AC157514
      Consensus CDS
      CCDS40753.1
      UniProtKB/Swiss-Prot
      Q8VD65
      Related
      ENSMUSP00000067400.7, ENSMUST00000065778.13
      Conserved Domains (8) summary
      smart00320
      Location:13271358
      WD40; WD40 repeats
      COG2319
      Location:9911358
      WD40; WD40 repeat [General function prediction only]
      cd13980
      Location:25320
      STKc_Vps15; Catalytic domain of the Serine/Threonine kinase, Vacuolar protein sorting-associated protein 15
      pfam00069
      Location:26309
      Pkinase; Protein kinase domain
      pfam07539
      Location:352449
      DRIM; Down-regulated in metastasis
      sd00044
      Location:539566
      HEAT; HEAT repeat [structural motif]
      sd00039
      Location:9971040
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:9851269
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      105520156..105564854
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036155370.1XP_036011263.1  phosphoinositide 3-kinase regulatory subunit 4 isoform X1

      Conserved Domains (5) summary
      smart00320
      Location:13351366
      WD40; WD40 repeats
      cd13980
      Location:25320
      STKc_Vps15; Catalytic domain of the Serine/Threonine kinase, Vacuolar protein sorting-associated protein 15
      sd00044
      Location:539566
      HEAT; HEAT repeat [structural motif]
      sd00039
      Location:10051048
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:9931277
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_029380.1: Suppressed sequence

      Description
      NM_029380.1: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.
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