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    Med25 mediator complex subunit 25 [ Mus musculus (house mouse) ]

    Gene ID: 75613, updated on 23-Jun-2021

    Summary

    Official Symbol
    Med25provided by MGI
    Official Full Name
    mediator complex subunit 25provided by MGI
    Primary source
    MGI:MGI:1922863
    See related
    Ensembl:ENSMUSG00000002968
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ESTM; ESTM2; 2610034E13Rik; 2610529E18Rik
    Expression
    Ubiquitous expression in adrenal adult (RPKM 84.2), ovary adult (RPKM 55.9) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Med25 in Genome Data Viewer
    Location:
    7 B3; 7 28.95 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (44526189..44544771, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (44876765..44892705, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (52134756..52147736, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene AKT1 substrate 1 (proline-rich) Neighboring gene microRNA 707 Neighboring gene polynucleotide kinase 3'- phosphatase Neighboring gene prostate tumor over expressed gene 1 Neighboring gene fuzzy planar cell polarity protein Neighboring gene adaptor-related protein complex 2, alpha 1 subunit Neighboring gene testis-specific serine kinase substrate

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables retinoic acid receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables retinoic acid receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables retinoid X receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables retinoid X receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription coactivator binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    part_of transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of transcription regulator complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 

    General protein information

    Preferred Names
    mediator of RNA polymerase II transcription subunit 25
    Names
    mediator of RNA polymerase II transcription, subunit 9 homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001331206.1NP_001318135.1  mediator of RNA polymerase II transcription subunit 25 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AK149867, AK158238, AK165760, AW495583, CB524888
      UniProtKB/Swiss-Prot
      Q8VCB2
    2. NM_001331207.1NP_001318136.1  mediator of RNA polymerase II transcription subunit 25 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC158231
      Consensus CDS
      CCDS90228.1
      UniProtKB/TrEMBL
      A0A140LHG7
      Related
      ENSMUSP00000146405.2, ENSMUST00000208253.2
    3. NM_001331208.1NP_001318137.1  mediator of RNA polymerase II transcription subunit 25 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC158231
      Consensus CDS
      CCDS85291.1
      UniProtKB/Swiss-Prot
      Q8VCB2
      Related
      ENSMUSP00000146595.2, ENSMUST00000207278.2
      Conserved Domains (5) summary
      pfam09770
      Location:459586
      PAT1; Topoisomerase II-associated protein PAT1
      pfam11232
      Location:297442
      Med25; Mediator complex subunit 25 PTOV activation and synapsin 2
      pfam11235
      Location:125280
      Med25_SD1; Mediator complex subunit 25 synapsin 1
      pfam11244
      Location:530618
      Med25_NR-box; Mediator complex subunit 25 C-terminal NR box-containing
      cl00057
      Location:1123
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    4. NM_029365.3NP_083641.1  mediator of RNA polymerase II transcription subunit 25 isoform 1

      See identical proteins and their annotated locations for NP_083641.1

      Status: VALIDATED

      Source sequence(s)
      AC158231
      Consensus CDS
      CCDS21220.1
      UniProtKB/Swiss-Prot
      Q8VCB2
      Related
      ENSMUSP00000003049.7, ENSMUST00000003049.8
      Conserved Domains (4) summary
      pfam11232
      Location:400545
      Med25; Mediator complex subunit 25 PTOV activation and synapsin 2
      pfam11235
      Location:228383
      Med25_SD1; Mediator complex subunit 25 synapsin 1
      pfam11244
      Location:663745
      Med25_NR-box; Mediator complex subunit 25 C-terminal NR box-containing
      pfam11265
      Location:13225
      Med25_VWA; Mediator complex subunit 25 von Willebrand factor type A

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      44526189..44544771 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017312366.3XP_017167855.1  mediator of RNA polymerase II transcription subunit 25 isoform X1

      Conserved Domains (5) summary
      pfam09770
      Location:620779
      PAT1; Topoisomerase II-associated protein PAT1
      pfam11232
      Location:460605
      Med25; Mediator complex subunit 25 PTOV activation and synapsin 2
      pfam11235
      Location:287443
      Med25_SD1; Mediator complex subunit 25 synapsin 1
      pfam11244
      Location:717773
      Med25_NR-box; Mediator complex subunit 25 C-terminal NR box-containing
      pfam11265
      Location:74285
      Med25_VWA; Mediator complex subunit 25 von Willebrand factor type A
    2. XM_030243066.2XP_030098926.1  mediator of RNA polymerase II transcription subunit 25 isoform X2

      Conserved Domains (5) summary
      pfam09770
      Location:618750
      PAT1; Topoisomerase II-associated protein PAT1
      pfam11232
      Location:459604
      Med25; Mediator complex subunit 25 PTOV activation and synapsin 2
      pfam11235
      Location:287442
      Med25_SD1; Mediator complex subunit 25 synapsin 1
      pfam11244
      Location:692748
      Med25_NR-box; Mediator complex subunit 25 C-terminal NR box-containing
      pfam11265
      Location:74285
      Med25_VWA; Mediator complex subunit 25 von Willebrand factor type A
    3. XM_036153534.1XP_036009427.1  mediator of RNA polymerase II transcription subunit 25 isoform X7

      Conserved Domains (6) summary
      pfam09770
      Location:483614
      PAT1; Topoisomerase II-associated protein PAT1
      pfam11232
      Location:297442
      Med25; Mediator complex subunit 25 PTOV activation and synapsin 2
      pfam11235
      Location:125280
      Med25_SD1; Mediator complex subunit 25 synapsin 1
      pfam11244
      Location:554610
      Med25_NR-box; Mediator complex subunit 25 C-terminal NR box-containing
      pfam18658
      Location:625683
      zf-C2H2_12; Zinc-finger C2H2-type
      cl00057
      Location:1123
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    4. XM_030243068.2XP_030098928.1  mediator of RNA polymerase II transcription subunit 25 isoform X8

      Conserved Domains (5) summary
      pfam09770
      Location:460589
      PAT1; Topoisomerase II-associated protein PAT1
      pfam11232
      Location:298443
      Med25; Mediator complex subunit 25 PTOV activation and synapsin 2
      pfam11235
      Location:125281
      Med25_SD1; Mediator complex subunit 25 synapsin 1
      pfam11244
      Location:531587
      Med25_NR-box; Mediator complex subunit 25 C-terminal NR box-containing
      cl00057
      Location:1123
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    5. XM_006541265.4XP_006541328.1  mediator of RNA polymerase II transcription subunit 25 isoform X6

      Conserved Domains (5) summary
      pfam09770
      Location:458617
      PAT1; Topoisomerase II-associated protein PAT1
      pfam11232
      Location:298443
      Med25; Mediator complex subunit 25 PTOV activation and synapsin 2
      pfam11235
      Location:125281
      Med25_SD1; Mediator complex subunit 25 synapsin 1
      pfam11244
      Location:555611
      Med25_NR-box; Mediator complex subunit 25 C-terminal NR box-containing
      cl00057
      Location:1123
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    6. XM_030243067.2XP_030098927.1  mediator of RNA polymerase II transcription subunit 25 isoform X7

      Conserved Domains (6) summary
      pfam09770
      Location:483614
      PAT1; Topoisomerase II-associated protein PAT1
      pfam11232
      Location:297442
      Med25; Mediator complex subunit 25 PTOV activation and synapsin 2
      pfam11235
      Location:125280
      Med25_SD1; Mediator complex subunit 25 synapsin 1
      pfam11244
      Location:554610
      Med25_NR-box; Mediator complex subunit 25 C-terminal NR box-containing
      pfam18658
      Location:625683
      zf-C2H2_12; Zinc-finger C2H2-type
      cl00057
      Location:1123
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    7. XM_017312368.2XP_017167857.1  mediator of RNA polymerase II transcription subunit 25 isoform X6

      Conserved Domains (5) summary
      pfam09770
      Location:458617
      PAT1; Topoisomerase II-associated protein PAT1
      pfam11232
      Location:298443
      Med25; Mediator complex subunit 25 PTOV activation and synapsin 2
      pfam11235
      Location:125281
      Med25_SD1; Mediator complex subunit 25 synapsin 1
      pfam11244
      Location:555611
      Med25_NR-box; Mediator complex subunit 25 C-terminal NR box-containing
      cl00057
      Location:1123
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    8. XM_006541264.3XP_006541327.1  mediator of RNA polymerase II transcription subunit 25 isoform X5

      Conserved Domains (5) summary
      pfam09770
      Location:621748
      PAT1; Topoisomerase II-associated protein PAT1
      pfam11232
      Location:459604
      Med25; Mediator complex subunit 25 PTOV activation and synapsin 2
      pfam11235
      Location:287442
      Med25_SD1; Mediator complex subunit 25 synapsin 1
      pfam11244
      Location:692780
      Med25_NR-box; Mediator complex subunit 25 C-terminal NR box-containing
      pfam11265
      Location:74285
      Med25_VWA; Mediator complex subunit 25 von Willebrand factor type A
    9. XM_017312367.3XP_017167856.1  mediator of RNA polymerase II transcription subunit 25 isoform X4

      Conserved Domains (5) summary
      pfam09770
      Location:622749
      PAT1; Topoisomerase II-associated protein PAT1
      pfam11232
      Location:460605
      Med25; Mediator complex subunit 25 PTOV activation and synapsin 2
      pfam11235
      Location:287443
      Med25_SD1; Mediator complex subunit 25 synapsin 1
      pfam11244
      Location:693781
      Med25_NR-box; Mediator complex subunit 25 C-terminal NR box-containing
      pfam11265
      Location:74285
      Med25_VWA; Mediator complex subunit 25 von Willebrand factor type A
    10. XM_006541263.3XP_006541326.1  mediator of RNA polymerase II transcription subunit 25 isoform X3

      Conserved Domains (5) summary
      pfam09770
      Location:620758
      PAT1; Topoisomerase II-associated protein PAT1
      pfam11232
      Location:460605
      Med25; Mediator complex subunit 25 PTOV activation and synapsin 2
      pfam11235
      Location:287443
      Med25_SD1; Mediator complex subunit 25 synapsin 1
      pfam11244
      Location:717805
      Med25_NR-box; Mediator complex subunit 25 C-terminal NR box-containing
      pfam11265
      Location:74285
      Med25_VWA; Mediator complex subunit 25 von Willebrand factor type A
    11. XM_030243073.2XP_030098933.1  mediator of RNA polymerase II transcription subunit 25 isoform X12

      Conserved Domains (5) summary
      pfam09770
      Location:459586
      PAT1; Topoisomerase II-associated protein PAT1
      pfam11232
      Location:297442
      Med25; Mediator complex subunit 25 PTOV activation and synapsin 2
      pfam11235
      Location:125280
      Med25_SD1; Mediator complex subunit 25 synapsin 1
      pfam11244
      Location:530618
      Med25_NR-box; Mediator complex subunit 25 C-terminal NR box-containing
      cl00057
      Location:1123
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    12. XM_030243070.2XP_030098930.1  mediator of RNA polymerase II transcription subunit 25 isoform X10

      Conserved Domains (5) summary
      pfam09770
      Location:457595
      PAT1; Topoisomerase II-associated protein PAT1
      pfam11232
      Location:297442
      Med25; Mediator complex subunit 25 PTOV activation and synapsin 2
      pfam11235
      Location:125280
      Med25_SD1; Mediator complex subunit 25 synapsin 1
      pfam11244
      Location:554642
      Med25_NR-box; Mediator complex subunit 25 C-terminal NR box-containing
      cl00057
      Location:1123
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    13. XM_030243071.2XP_030098931.1  mediator of RNA polymerase II transcription subunit 25 isoform X10

      Conserved Domains (5) summary
      pfam09770
      Location:457595
      PAT1; Topoisomerase II-associated protein PAT1
      pfam11232
      Location:297442
      Med25; Mediator complex subunit 25 PTOV activation and synapsin 2
      pfam11235
      Location:125280
      Med25_SD1; Mediator complex subunit 25 synapsin 1
      pfam11244
      Location:554642
      Med25_NR-box; Mediator complex subunit 25 C-terminal NR box-containing
      cl00057
      Location:1123
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    14. XM_030243072.2XP_030098932.1  mediator of RNA polymerase II transcription subunit 25 isoform X11

      Conserved Domains (5) summary
      pfam09770
      Location:460587
      PAT1; Topoisomerase II-associated protein PAT1
      pfam11232
      Location:298443
      Med25; Mediator complex subunit 25 PTOV activation and synapsin 2
      pfam11235
      Location:125281
      Med25_SD1; Mediator complex subunit 25 synapsin 1
      pfam11244
      Location:531619
      Med25_NR-box; Mediator complex subunit 25 C-terminal NR box-containing
      cl00057
      Location:1123
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    15. XM_030243069.2XP_030098929.1  mediator of RNA polymerase II transcription subunit 25 isoform X9

      Conserved Domains (5) summary
      pfam09770
      Location:458596
      PAT1; Topoisomerase II-associated protein PAT1
      pfam11232
      Location:298443
      Med25; Mediator complex subunit 25 PTOV activation and synapsin 2
      pfam11235
      Location:125281
      Med25_SD1; Mediator complex subunit 25 synapsin 1
      pfam11244
      Location:555643
      Med25_NR-box; Mediator complex subunit 25 C-terminal NR box-containing
      cl00057
      Location:1123
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
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