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    Ep400 E1A binding protein p400 [ Mus musculus (house mouse) ]

    Gene ID: 75560, updated on 22-Aug-2021

    Summary

    Official Symbol
    Ep400provided by MGI
    Official Full Name
    E1A binding protein p400provided by MGI
    Primary source
    MGI:MGI:1276124
    See related
    Ensembl:ENSMUSG00000029505
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mDo; p40; p400; mDomino; AU023439; mKIAA1498; 1700020J09Rik
    Expression
    Ubiquitous expression in testis adult (RPKM 36.8), thymus adult (RPKM 23.6) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Ep400 in Genome Data Viewer
    Location:
    5; 5 F
    Exon count:
    56
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (110812239..110918780, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (110664373..110770927, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (111093392..111199736, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene NOC4 like Neighboring gene DEAD box helicase 51 Neighboring gene microRNA 7026 Neighboring gene predicted gene, 22716 Neighboring gene predicted gene, 26079 Neighboring gene predicted gene, 22583 Neighboring gene predicted gene 15559 Neighboring gene pseudouridine synthase 1 Neighboring gene unc-51 like kinase 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP-dependent chromatin remodeler activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein antigen binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within chromatin organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in histone H2A acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in histone H4 acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of NuA4 histone acetyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of Swr1 complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    E1A-binding protein p400
    Names
    domino homolog
    p400 kDa SWI2/SNF2-related protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029337.2NP_083613.2  E1A-binding protein p400 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform.
      Source sequence(s)
      AC161348
      Consensus CDS
      CCDS19529.1
      UniProtKB/Swiss-Prot
      Q8CHI8
      Related
      ENSMUSP00000049038.9, ENSMUST00000041558.15
      Conserved Domains (7) summary
      PHA03255
      Location:25112639
      PHA03255; BDLF3; Provisional
      smart00573
      Location:762833
      HSA; domain in helicases and associated with SANT domains
      cd00046
      Location:10731208
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam00176
      Location:10561336
      SNF2_N; SNF2 family N-terminal domain
      pfam00271
      Location:17761892
      Helicase_C; Helicase conserved C-terminal domain
      pfam03153
      Location:28223011
      TFIIA; Transcription factor IIA, alpha/beta subunit
      pfam15790
      Location:1451
      EP400_N; E1A-binding protein p400, N-terminal
    2. NM_173066.1NP_775089.1  E1A-binding protein p400 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2), also called mDomino-S, lacks an in-frame exon, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
      Source sequence(s)
      AC161348
      Consensus CDS
      CCDS51612.1
      UniProtKB/Swiss-Prot
      Q8CHI8
      Related
      ENSMUSP00000108055.3, ENSMUST00000112436.9
      Conserved Domains (7) summary
      PHA03255
      Location:24752603
      PHA03255; BDLF3; Provisional
      smart00573
      Location:726797
      HSA; domain in helicases and associated with SANT domains
      cd00046
      Location:10371172
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam00176
      Location:10201300
      SNF2_N; SNF2 family N-terminal domain
      pfam00271
      Location:17401856
      Helicase_C; Helicase conserved C-terminal domain
      pfam03153
      Location:27862975
      TFIIA; Transcription factor IIA, alpha/beta subunit
      pfam15790
      Location:1451
      EP400_N; E1A-binding protein p400, N-terminal

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      110812239..110918780 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017321133.2XP_017176622.1  E1A-binding protein p400 isoform X8

      Conserved Domains (7) summary
      smart00573
      Location:762833
      HSA; domain in helicases and associated with SANT domains
      PHA03247
      Location:14061707
      PHA03247; large tegument protein UL36; Provisional
      cd18793
      Location:18571982
      SF2_C_SNF; C-terminal helicase domain of the SNF family helicases
      pfam03154
      Location:448715
      Atrophin-1; Atrophin-1 family
      pfam07890
      Location:796884
      Rrp15p
      pfam15790
      Location:1451
      EP400_N; E1A-binding protein p400, N-terminal
      cl28899
      Location:10531269
      DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily
    2. XM_030254870.1XP_030110730.1  E1A-binding protein p400 isoform X8

      Conserved Domains (7) summary
      smart00573
      Location:762833
      HSA; domain in helicases and associated with SANT domains
      PHA03247
      Location:14061707
      PHA03247; large tegument protein UL36; Provisional
      cd18793
      Location:18571982
      SF2_C_SNF; C-terminal helicase domain of the SNF family helicases
      pfam03154
      Location:448715
      Atrophin-1; Atrophin-1 family
      pfam07890
      Location:796884
      Rrp15p
      pfam15790
      Location:1451
      EP400_N; E1A-binding protein p400, N-terminal
      cl28899
      Location:10531269
      DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily
    3. XM_036165578.1XP_036021471.1  E1A-binding protein p400 isoform X9

      Conserved Domains (6) summary
      smart00573
      Location:726797
      HSA; domain in helicases and associated with SANT domains
      PHA03247
      Location:13701671
      PHA03247; large tegument protein UL36; Provisional
      cd18793
      Location:18211946
      SF2_C_SNF; C-terminal helicase domain of the SNF family helicases
      pfam15790
      Location:1451
      EP400_N; E1A-binding protein p400, N-terminal
      cl28899
      Location:10171233
      DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily
      cl41773
      Location:28763088
      SP1-4_N; N-terminal domain of transcription factor Specificity Proteins (SP) 1-4
    4. XM_017321134.3XP_017176623.1  E1A-binding protein p400 isoform X9

      Conserved Domains (6) summary
      smart00573
      Location:726797
      HSA; domain in helicases and associated with SANT domains
      PHA03247
      Location:13701671
      PHA03247; large tegument protein UL36; Provisional
      cd18793
      Location:18211946
      SF2_C_SNF; C-terminal helicase domain of the SNF family helicases
      pfam15790
      Location:1451
      EP400_N; E1A-binding protein p400, N-terminal
      cl28899
      Location:10171233
      DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily
      cl41773
      Location:28763088
      SP1-4_N; N-terminal domain of transcription factor Specificity Proteins (SP) 1-4
    5. XM_017321132.3XP_017176621.1  E1A-binding protein p400 isoform X7

      Conserved Domains (5) summary
      smart00573
      Location:763834
      HSA; domain in helicases and associated with SANT domains
      PHA03247
      Location:14071708
      PHA03247; large tegument protein UL36; Provisional
      cd18793
      Location:18581983
      SF2_C_SNF; C-terminal helicase domain of the SNF family helicases
      pfam15790
      Location:1506
      EP400_N; E1A-binding protein p400, N-terminal
      cl28899
      Location:10541270
      DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily
    6. XM_030254872.2XP_030110732.1  E1A-binding protein p400 isoform X12

      Conserved Domains (7) summary
      smart00573
      Location:799870
      HSA; domain in helicases and associated with SANT domains
      PHA03247
      Location:14441663
      PHA03247; large tegument protein UL36; Provisional
      cd18793
      Location:18131938
      SF2_C_SNF; C-terminal helicase domain of the SNF family helicases
      pfam03154
      Location:455752
      Atrophin-1; Atrophin-1 family
      pfam07890
      Location:833921
      Rrp15p
      pfam15790
      Location:1506
      EP400_N; E1A-binding protein p400, N-terminal
      cl28899
      Location:10901306
      DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily
    7. XM_006535276.5XP_006535339.1  E1A-binding protein p400 isoform X13

      UniProtKB/Swiss-Prot
      Q8CHI8
      Related
      ENSMUSP00000108054.3, ENSMUST00000112435.9
      Conserved Domains (7) summary
      smart00573
      Location:799870
      HSA; domain in helicases and associated with SANT domains
      PHA03247
      Location:14441663
      PHA03247; large tegument protein UL36; Provisional
      cd18793
      Location:18131938
      SF2_C_SNF; C-terminal helicase domain of the SNF family helicases
      pfam03154
      Location:455752
      Atrophin-1; Atrophin-1 family
      pfam07890
      Location:833921
      Rrp15p
      pfam15790
      Location:1506
      EP400_N; E1A-binding protein p400, N-terminal
      cl28899
      Location:10901306
      DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily
    8. XM_017321135.3XP_017176624.1  E1A-binding protein p400 isoform X10

      Conserved Domains (7) summary
      smart00573
      Location:799870
      HSA; domain in helicases and associated with SANT domains
      PHA03247
      Location:14441663
      PHA03247; large tegument protein UL36; Provisional
      cd18793
      Location:18131938
      SF2_C_SNF; C-terminal helicase domain of the SNF family helicases
      pfam03154
      Location:455752
      Atrophin-1; Atrophin-1 family
      pfam07890
      Location:833921
      Rrp15p
      pfam15790
      Location:1506
      EP400_N; E1A-binding protein p400, N-terminal
      cl28899
      Location:10901306
      DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily
    9. XM_036165577.1XP_036021470.1  E1A-binding protein p400 isoform X5

      Conserved Domains (7) summary
      smart00573
      Location:799870
      HSA; domain in helicases and associated with SANT domains
      PHA03247
      Location:14431744
      PHA03247; large tegument protein UL36; Provisional
      PRK10927
      Location:499603
      PRK10927; cell division protein FtsN
      cd18793
      Location:18942019
      SF2_C_SNF; C-terminal helicase domain of the SNF family helicases
      pfam15790
      Location:1506
      EP400_N; E1A-binding protein p400, N-terminal
      cl28899
      Location:10901306
      DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily
      cl41773
      Location:29313143
      SP1-4_N; N-terminal domain of transcription factor Specificity Proteins (SP) 1-4
    10. XM_017321131.3XP_017176620.1  E1A-binding protein p400 isoform X2

      Conserved Domains (7) summary
      smart00573
      Location:799870
      HSA; domain in helicases and associated with SANT domains
      PHA03247
      Location:14431744
      PHA03247; large tegument protein UL36; Provisional
      cd18793
      Location:18942019
      SF2_C_SNF; C-terminal helicase domain of the SNF family helicases
      pfam03154
      Location:455752
      Atrophin-1; Atrophin-1 family
      pfam07890
      Location:833921
      Rrp15p
      pfam15790
      Location:1506
      EP400_N; E1A-binding protein p400, N-terminal
      cl28899
      Location:10901306
      DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily
    11. XM_006535271.5XP_006535334.1  E1A-binding protein p400 isoform X6

      Conserved Domains (7) summary
      smart00573
      Location:799870
      HSA; domain in helicases and associated with SANT domains
      PHA03247
      Location:14431744
      PHA03247; large tegument protein UL36; Provisional
      cd18793
      Location:18942019
      SF2_C_SNF; C-terminal helicase domain of the SNF family helicases
      pfam03154
      Location:455752
      Atrophin-1; Atrophin-1 family
      pfam07890
      Location:833921
      Rrp15p
      pfam15790
      Location:1506
      EP400_N; E1A-binding protein p400, N-terminal
      cl28899
      Location:10901306
      DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily
    12. XM_006535269.5XP_006535332.1  E1A-binding protein p400 isoform X3

      Conserved Domains (7) summary
      smart00573
      Location:799870
      HSA; domain in helicases and associated with SANT domains
      PHA03247
      Location:14431744
      PHA03247; large tegument protein UL36; Provisional
      cd18793
      Location:18942019
      SF2_C_SNF; C-terminal helicase domain of the SNF family helicases
      pfam03154
      Location:455752
      Atrophin-1; Atrophin-1 family
      pfam07890
      Location:833921
      Rrp15p
      pfam15790
      Location:1506
      EP400_N; E1A-binding protein p400, N-terminal
      cl28899
      Location:10901306
      DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily
    13. XM_006535265.5XP_006535328.1  E1A-binding protein p400 isoform X1

      Conserved Domains (7) summary
      smart00573
      Location:799870
      HSA; domain in helicases and associated with SANT domains
      PHA03247
      Location:14431744
      PHA03247; large tegument protein UL36; Provisional
      cd18793
      Location:18942019
      SF2_C_SNF; C-terminal helicase domain of the SNF family helicases
      pfam03154
      Location:455752
      Atrophin-1; Atrophin-1 family
      pfam07890
      Location:833921
      Rrp15p
      pfam15790
      Location:1506
      EP400_N; E1A-binding protein p400, N-terminal
      cl28899
      Location:10901306
      DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily
    14. XM_017321130.3XP_017176619.1  E1A-binding protein p400 isoform X1

      Conserved Domains (7) summary
      smart00573
      Location:799870
      HSA; domain in helicases and associated with SANT domains
      PHA03247
      Location:14431744
      PHA03247; large tegument protein UL36; Provisional
      cd18793
      Location:18942019
      SF2_C_SNF; C-terminal helicase domain of the SNF family helicases
      pfam03154
      Location:455752
      Atrophin-1; Atrophin-1 family
      pfam07890
      Location:833921
      Rrp15p
      pfam15790
      Location:1506
      EP400_N; E1A-binding protein p400, N-terminal
      cl28899
      Location:10901306
      DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily
    15. XM_030254869.1XP_030110729.1  E1A-binding protein p400 isoform X8

      Conserved Domains (7) summary
      smart00573
      Location:762833
      HSA; domain in helicases and associated with SANT domains
      PHA03247
      Location:14061707
      PHA03247; large tegument protein UL36; Provisional
      cd18793
      Location:18571982
      SF2_C_SNF; C-terminal helicase domain of the SNF family helicases
      pfam03154
      Location:448715
      Atrophin-1; Atrophin-1 family
      pfam07890
      Location:796884
      Rrp15p
      pfam15790
      Location:1451
      EP400_N; E1A-binding protein p400, N-terminal
      cl28899
      Location:10531269
      DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily
    16. XM_030254871.1XP_030110731.1  E1A-binding protein p400 isoform X9

      Conserved Domains (6) summary
      smart00573
      Location:726797
      HSA; domain in helicases and associated with SANT domains
      PHA03247
      Location:13701671
      PHA03247; large tegument protein UL36; Provisional
      cd18793
      Location:18211946
      SF2_C_SNF; C-terminal helicase domain of the SNF family helicases
      pfam15790
      Location:1451
      EP400_N; E1A-binding protein p400, N-terminal
      cl28899
      Location:10171233
      DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily
      cl41773
      Location:28763088
      SP1-4_N; N-terminal domain of transcription factor Specificity Proteins (SP) 1-4
    17. XM_017321129.2XP_017176618.1  E1A-binding protein p400 isoform X1

      Conserved Domains (7) summary
      smart00573
      Location:799870
      HSA; domain in helicases and associated with SANT domains
      PHA03247
      Location:14431744
      PHA03247; large tegument protein UL36; Provisional
      cd18793
      Location:18942019
      SF2_C_SNF; C-terminal helicase domain of the SNF family helicases
      pfam03154
      Location:455752
      Atrophin-1; Atrophin-1 family
      pfam07890
      Location:833921
      Rrp15p
      pfam15790
      Location:1506
      EP400_N; E1A-binding protein p400, N-terminal
      cl28899
      Location:10901306
      DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily
    18. XM_006535277.5XP_006535340.1  E1A-binding protein p400 isoform X14

      Conserved Domains (7) summary
      smart00573
      Location:762833
      HSA; domain in helicases and associated with SANT domains
      PHA03247
      Location:14061707
      PHA03247; large tegument protein UL36; Provisional
      cd18793
      Location:18571982
      SF2_C_SNF; C-terminal helicase domain of the SNF family helicases
      pfam03154
      Location:448715
      Atrophin-1; Atrophin-1 family
      pfam07890
      Location:796884
      Rrp15p
      pfam15790
      Location:1451
      EP400_N; E1A-binding protein p400, N-terminal
      cl28899
      Location:10531269
      DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily
    19. XM_036165579.1XP_036021472.1  E1A-binding protein p400 isoform X11

      Conserved Domains (7) summary
      smart00573
      Location:799870
      HSA; domain in helicases and associated with SANT domains
      PHA03247
      Location:572762
      PHA03247; large tegument protein UL36; Provisional
      PRK10927
      Location:499603
      PRK10927; cell division protein FtsN
      cd18793
      Location:18131938
      SF2_C_SNF; C-terminal helicase domain of the SNF family helicases
      pfam15790
      Location:1506
      EP400_N; E1A-binding protein p400, N-terminal
      cl28899
      Location:10901306
      DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily
      cl41773
      Location:28523064
      SP1-4_N; N-terminal domain of transcription factor Specificity Proteins (SP) 1-4
    20. XM_006535270.5XP_006535333.1  E1A-binding protein p400 isoform X4

      Conserved Domains (7) summary
      smart00573
      Location:799870
      HSA; domain in helicases and associated with SANT domains
      PHA03247
      Location:14431744
      PHA03247; large tegument protein UL36; Provisional
      cd18793
      Location:18942019
      SF2_C_SNF; C-terminal helicase domain of the SNF family helicases
      pfam03154
      Location:455752
      Atrophin-1; Atrophin-1 family
      pfam07890
      Location:833921
      Rrp15p
      pfam15790
      Location:1506
      EP400_N; E1A-binding protein p400, N-terminal
      cl28899
      Location:10901306
      DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily
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