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    Ep400 E1A binding protein p400 [ Mus musculus (house mouse) ]

    Gene ID: 75560, updated on 5-Aug-2018

    Summary

    Official Symbol
    Ep400provided by MGI
    Official Full Name
    E1A binding protein p400provided by MGI
    Primary source
    MGI:MGI:1276124
    See related
    Ensembl:ENSMUSG00000029505 Vega:OTTMUSG00000017135
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    p400; mDomino; AU023439; mKIAA1498; 1700020J09Rik
    Expression
    Ubiquitous expression in testis adult (RPKM 36.8), thymus adult (RPKM 23.6) and 28 other tissues See more
    Orthologs

    Genomic context

    See Ep400 in Genome Data Viewer
    Location:
    5; 5 F
    Exon count:
    56
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (110664373..110770886, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (111093392..111199736, complement)

    Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene NOC4 like Neighboring gene DEAD (Asp-Glu-Ala-Asp) box polypeptide 51 Neighboring gene microRNA 7026 Neighboring gene predicted gene 15559 Neighboring gene predicted gene, 26515 Neighboring gene pseudouridine synthase 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein antigen binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    chromatin organization IEA
    Inferred from Electronic Annotation
    more info
     
    histone H2A acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    histone H4 acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    NuA4 histone acetyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
     
    Swr1 complex ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear speck IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    E1A-binding protein p400
    Names
    domino homolog
    p400 kDa SWI2/SNF2-related protein

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029337.2NP_083613.2  E1A-binding protein p400 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform.
      Source sequence(s)
      AC161348
      Consensus CDS
      CCDS19529.1
      UniProtKB/Swiss-Prot
      Q8CHI8
      Related
      ENSMUSP00000049038.8, OTTMUSP00000018627, ENSMUST00000041558.14, OTTMUST00000041482
      Conserved Domains (7) summary
      PHA03255
      Location:25112639
      PHA03255; BDLF3; Provisional
      smart00573
      Location:762833
      HSA; domain in helicases and associated with SANT domains
      cd00046
      Location:10731208
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam00176
      Location:10561336
      SNF2_N; SNF2 family N-terminal domain
      pfam00271
      Location:17761892
      Helicase_C; Helicase conserved C-terminal domain
      pfam03153
      Location:28223011
      TFIIA; Transcription factor IIA, alpha/beta subunit
      pfam15790
      Location:1451
      EP400_N; E1A-binding protein p400, N-terminal
    2. NM_173066.1NP_775089.1  E1A-binding protein p400 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2), also called mDomino-S, lacks an in-frame exon, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
      Source sequence(s)
      AC161348
      Consensus CDS
      CCDS51612.1
      UniProtKB/Swiss-Prot
      Q8CHI8
      Related
      ENSMUSP00000108055.2, OTTMUSP00000018626, ENSMUST00000112436.8, OTTMUST00000041481
      Conserved Domains (7) summary
      PHA03255
      Location:24752603
      PHA03255; BDLF3; Provisional
      smart00573
      Location:726797
      HSA; domain in helicases and associated with SANT domains
      cd00046
      Location:10371172
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam00176
      Location:10201300
      SNF2_N; SNF2 family N-terminal domain
      pfam00271
      Location:17401856
      Helicase_C; Helicase conserved C-terminal domain
      pfam03153
      Location:27862975
      TFIIA; Transcription factor IIA, alpha/beta subunit
      pfam15790
      Location:1451
      EP400_N; E1A-binding protein p400, N-terminal

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

      Range
      110664373..110770886 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017321130.1XP_017176619.1  E1A-binding protein p400 isoform X1

      Conserved Domains (7) summary
      PHA03255
      Location:26452773
      PHA03255; BDLF3; Provisional
      smart00573
      Location:799870
      HSA; domain in helicases and associated with SANT domains
      cd00046
      Location:11101245
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam00176
      Location:10931373
      SNF2_N; SNF2 family N-terminal domain
      pfam00271
      Location:18942010
      Helicase_C; Helicase conserved C-terminal domain
      pfam03153
      Location:29563145
      TFIIA; Transcription factor IIA, alpha/beta subunit
      pfam15790
      Location:1506
      EP400_N; E1A-binding protein p400, N-terminal
    2. XM_017321134.1XP_017176623.1  E1A-binding protein p400 isoform X8

    3. XM_006535277.3XP_006535340.1  E1A-binding protein p400 isoform X11

      Conserved Domains (7) summary
      PHA03255
      Location:25922720
      PHA03255; BDLF3; Provisional
      smart00573
      Location:762833
      HSA; domain in helicases and associated with SANT domains
      cd00046
      Location:10731208
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam00176
      Location:10561336
      SNF2_N; SNF2 family N-terminal domain
      pfam00271
      Location:18571973
      Helicase_C; Helicase conserved C-terminal domain
      pfam03153
      Location:29033092
      TFIIA; Transcription factor IIA, alpha/beta subunit
      pfam15790
      Location:1451
      EP400_N; E1A-binding protein p400, N-terminal
    4. XM_017321133.1XP_017176622.1  E1A-binding protein p400 isoform X7

    5. XM_017321132.1XP_017176621.1  E1A-binding protein p400 isoform X6

    6. XM_017321135.1XP_017176624.1  E1A-binding protein p400 isoform X9

    7. XM_017321131.1XP_017176620.1  E1A-binding protein p400 isoform X2

    8. XM_006535270.3XP_006535333.1  E1A-binding protein p400 isoform X4

      Conserved Domains (7) summary
      PHA03255
      Location:26292757
      PHA03255; BDLF3; Provisional
      smart00573
      Location:799870
      HSA; domain in helicases and associated with SANT domains
      cd00046
      Location:11101245
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam00176
      Location:10931373
      SNF2_N; SNF2 family N-terminal domain
      pfam00271
      Location:18942010
      Helicase_C; Helicase conserved C-terminal domain
      pfam03153
      Location:29403129
      TFIIA; Transcription factor IIA, alpha/beta subunit
      pfam15790
      Location:1506
      EP400_N; E1A-binding protein p400, N-terminal
    9. XM_006535269.3XP_006535332.1  E1A-binding protein p400 isoform X3

      Conserved Domains (7) summary
      PHA03255
      Location:26452773
      PHA03255; BDLF3; Provisional
      smart00573
      Location:799870
      HSA; domain in helicases and associated with SANT domains
      cd00046
      Location:11101245
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam00176
      Location:10931373
      SNF2_N; SNF2 family N-terminal domain
      pfam00271
      Location:18942010
      Helicase_C; Helicase conserved C-terminal domain
      pfam03153
      Location:29493138
      TFIIA; Transcription factor IIA, alpha/beta subunit
      pfam15790
      Location:1506
      EP400_N; E1A-binding protein p400, N-terminal
    10. XM_006535265.3XP_006535328.1  E1A-binding protein p400 isoform X1

      Conserved Domains (7) summary
      PHA03255
      Location:26452773
      PHA03255; BDLF3; Provisional
      smart00573
      Location:799870
      HSA; domain in helicases and associated with SANT domains
      cd00046
      Location:11101245
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam00176
      Location:10931373
      SNF2_N; SNF2 family N-terminal domain
      pfam00271
      Location:18942010
      Helicase_C; Helicase conserved C-terminal domain
      pfam03153
      Location:29563145
      TFIIA; Transcription factor IIA, alpha/beta subunit
      pfam15790
      Location:1506
      EP400_N; E1A-binding protein p400, N-terminal
    11. XM_017321129.1XP_017176618.1  E1A-binding protein p400 isoform X1

      Conserved Domains (7) summary
      PHA03255
      Location:26452773
      PHA03255; BDLF3; Provisional
      smart00573
      Location:799870
      HSA; domain in helicases and associated with SANT domains
      cd00046
      Location:11101245
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam00176
      Location:10931373
      SNF2_N; SNF2 family N-terminal domain
      pfam00271
      Location:18942010
      Helicase_C; Helicase conserved C-terminal domain
      pfam03153
      Location:29563145
      TFIIA; Transcription factor IIA, alpha/beta subunit
      pfam15790
      Location:1506
      EP400_N; E1A-binding protein p400, N-terminal
    12. XM_006535276.3XP_006535339.1  E1A-binding protein p400 isoform X10

      UniProtKB/Swiss-Prot
      Q8CHI8
      Related
      ENSMUSP00000108054.2, ENSMUST00000112435.8
      Conserved Domains (7) summary
      PHA03255
      Location:25482676
      PHA03255; BDLF3; Provisional
      smart00573
      Location:799870
      HSA; domain in helicases and associated with SANT domains
      cd00046
      Location:11101245
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam00176
      Location:10931373
      SNF2_N; SNF2 family N-terminal domain
      pfam00271
      Location:18131929
      Helicase_C; Helicase conserved C-terminal domain
      pfam03153
      Location:28523041
      TFIIA; Transcription factor IIA, alpha/beta subunit
      pfam15790
      Location:1506
      EP400_N; E1A-binding protein p400, N-terminal
    13. XM_006535271.3XP_006535334.1  E1A-binding protein p400 isoform X5

      Conserved Domains (7) summary
      PHA03255
      Location:26292757
      PHA03255; BDLF3; Provisional
      smart00573
      Location:799870
      HSA; domain in helicases and associated with SANT domains
      cd00046
      Location:11101245
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam00176
      Location:10931373
      SNF2_N; SNF2 family N-terminal domain
      pfam00271
      Location:18942010
      Helicase_C; Helicase conserved C-terminal domain
      pfam03153
      Location:29333122
      TFIIA; Transcription factor IIA, alpha/beta subunit
      pfam15790
      Location:1506
      EP400_N; E1A-binding protein p400, N-terminal
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