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    ZNF7 zinc finger protein 7 [ Homo sapiens (human) ]

    Gene ID: 7553, updated on 3-Apr-2024

    Summary

    Official Symbol
    ZNF7provided by HGNC
    Official Full Name
    zinc finger protein 7provided by HGNC
    Primary source
    HGNC:HGNC:13139
    See related
    Ensembl:ENSG00000147789 MIM:194531; AllianceGenome:HGNC:13139
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    KOX4; zf30; HF.16
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be integral component of membrane. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis (RPKM 4.3), endometrium (RPKM 3.5) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ZNF7 in Genome Data Viewer
    Location:
    8q24.3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (144827560..144847508)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (146001303..146021302)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (146052945..146072893)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19709 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:146018867-146019815 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:146021109-146022007 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:146022008-146022906 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19710 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19711 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19712 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:146024705-146025602 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:146025603-146026501 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:146026502-146027399 Neighboring gene microRNA 6850 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28105 Neighboring gene ribosomal protein L8 Neighboring gene uncharacterized LOC100130027 Neighboring gene zinc finger protein 517 Neighboring gene hESC enhancers GRCh37_chr8:146052597-146053122 and GRCh37_chr8:146053123-146053648 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:146053649-146054174 Neighboring gene OCT4-H3K4me1 hESC enhancer GRCh37_chr8:146064238-146064791 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:146076290-146076441 Neighboring gene COMM domain containing 5 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:146077648-146078496 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19714 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28107 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28108 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28109 Neighboring gene zinc finger protein 250 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:146126184-146126788 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:146126789-146127391 Neighboring gene uncharacterized LOC124902042 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:146127392-146127995 Neighboring gene zinc finger protein 16 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19717

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ38706

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    zinc finger protein 7
    Names
    C2-H2 type zinc finger protein
    Zinc finger protein-7 (KOX4)
    zinc finger protein 7 (KOX 4, clone HF.16)
    zinc finger protein HF.16
    zinc finger protein KOX4
    zinc finger protein zfp30

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001282795.2NP_001269724.1  zinc finger protein 7 isoform 1

      See identical proteins and their annotated locations for NP_001269724.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AF235103, AK300001
      Consensus CDS
      CCDS64996.1
      UniProtKB/TrEMBL
      B2R9D8
      Related
      ENSP00000393260.2, ENST00000446747.7
      Conserved Domains (7) summary
      PHA02693
      Location:54127
      PHA02693; hypothetical protein; Provisional
      smart00349
      Location:1576
      KRAB; krueppel associated box
      COG5048
      Location:229686
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:454474
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:592614
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:1552
      KRAB; KRAB box
      pfam13465
      Location:360384
      zf-H2C2_2; Zinc-finger double domain
    2. NM_001282796.2NP_001269725.1  zinc finger protein 7 isoform 3

      See identical proteins and their annotated locations for NP_001269725.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate 3' terminal exon compared to variant 1. The enocded isoform (3) is shorter and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AF235103, AI862153, AK096025
      Consensus CDS
      CCDS64998.1
      UniProtKB/Swiss-Prot
      P17097
      Related
      ENSP00000435252.1, ENST00000525266.5
      Conserved Domains (3) summary
      smart00349
      Location:465
      KRAB; krueppel associated box
      pfam01352
      Location:441
      KRAB; KRAB box
      pfam10212
      Location:30129
      TTKRSYEDQ; Predicted coiled-coil domain-containing protein
    3. NM_001282797.2NP_001269726.1  zinc finger protein 7 isoform 4

      See identical proteins and their annotated locations for NP_001269726.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an exon in the 5' UTR which results in the use of a downstream start codon, compared to variant 1. The encoded isoform (4) has a shorter N-terminus, compared to isoform 1. Variants 4 and 6 encode the same protein (isoform 4).
      Source sequence(s)
      AF235103, AK301561, M29580
      Consensus CDS
      CCDS64999.1
      UniProtKB/TrEMBL
      F5H290, Q59F42
      Related
      ENSP00000439424.1, ENST00000544249.2
      Conserved Domains (2) summary
      COG5048
      Location:122543
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:347367
      ZF_C2H2; C2H2 Zn finger [structural motif]
    4. NM_001330623.1NP_001317552.1  zinc finger protein 7 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AF235103, AK300001, DA538365
      Consensus CDS
      CCDS83336.1
      UniProtKB/TrEMBL
      E9PIH3
      Related
      ENSP00000318848.5, ENST00000325217.10
    5. NM_001349805.2NP_001336734.1  zinc finger protein 7 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AF235103, BC058923, DB554904, DC345768, M29580
      Consensus CDS
      CCDS64999.1
      UniProtKB/TrEMBL
      F5H290, Q59F42
      Conserved Domains (2) summary
      COG5048
      Location:122543
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:347367
      ZF_C2H2; C2H2 Zn finger [structural motif]
    6. NM_001349806.2NP_001336735.1  zinc finger protein 7 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AF235103, BC058923, BJ989518, DB554904, DC345768, DC357767, M29580
      UniProtKB/TrEMBL
      B2R9D8
      Conserved Domains (4) summary
      smart00349
      Location:2182
      KRAB; krueppel associated box
      COG5048
      Location:235692
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:460480
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl28640
      Location:60133
      PHA02693; hypothetical protein; Provisional
    7. NM_001349807.2NP_001336736.1  zinc finger protein 7 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AF235103, BC058923, BJ989518, DA926250, DB554904, DC345768, M29580
      Consensus CDS
      CCDS94368.1
      UniProtKB/TrEMBL
      B2R9D8, E9PJX9
      Related
      ENSP00000433656.2, ENST00000527218.6
      Conserved Domains (4) summary
      smart00349
      Location:464
      KRAB; krueppel associated box
      COG5048
      Location:217674
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:442462
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl28640
      Location:46115
      PHA02693; hypothetical protein; Provisional
    8. NM_001349808.2NP_001336737.1  zinc finger protein 7 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AF235103, BC058923, BJ989518, CD617091, DB554904, DC345768, DC357767, M29580
      UniProtKB/TrEMBL
      B2R9D8
      Conserved Domains (4) summary
      smart00349
      Location:2181
      KRAB; krueppel associated box
      COG5048
      Location:234691
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:459479
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl28640
      Location:63132
      PHA02693; hypothetical protein; Provisional
    9. NM_001349809.2NP_001336738.1  zinc finger protein 7 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AF235103, BC058923, CT004931, DB554904, DC345768, DC357767, M29580
      UniProtKB/TrEMBL
      B2R9D8
      Conserved Domains (4) summary
      smart00349
      Location:2586
      KRAB; krueppel associated box
      COG5048
      Location:239696
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:464484
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl28640
      Location:64137
      PHA02693; hypothetical protein; Provisional
    10. NM_003416.4NP_003407.1  zinc finger protein 7 isoform 2

      See identical proteins and their annotated locations for NP_003407.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AF235103, BC058923
      Consensus CDS
      CCDS6435.1
      UniProtKB/Swiss-Prot
      B4DT08, D3DWN6, P17015, P17097, Q8N8Y4
      UniProtKB/TrEMBL
      B2R9D8
      Related
      ENSP00000432641.2, ENST00000532777.6
      Conserved Domains (7) summary
      PHA02693
      Location:43116
      PHA02693; hypothetical protein; Provisional
      smart00349
      Location:465
      KRAB; krueppel associated box
      COG5048
      Location:218675
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:443463
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:581603
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:441
      KRAB; KRAB box
      pfam13465
      Location:349373
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      144827560..144847508
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047422206.1XP_047278162.1  zinc finger protein 7 isoform X7

    2. XM_017013816.3XP_016869305.1  zinc finger protein 7 isoform X8

    3. XM_011517294.3XP_011515596.1  zinc finger protein 7 isoform X1

      See identical proteins and their annotated locations for XP_011515596.1

      UniProtKB/Swiss-Prot
      B4DT08, D3DWN6, P17015, P17097, Q8N8Y4
      UniProtKB/TrEMBL
      B2R9D8
      Conserved Domains (7) summary
      PHA02693
      Location:43116
      PHA02693; hypothetical protein; Provisional
      smart00349
      Location:465
      KRAB; krueppel associated box
      COG5048
      Location:218675
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:443463
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:581603
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:441
      KRAB; KRAB box
      pfam13465
      Location:349373
      zf-H2C2_2; Zinc-finger double domain
    4. XM_011517292.4XP_011515594.1  zinc finger protein 7 isoform X5

      See identical proteins and their annotated locations for XP_011515594.1

      UniProtKB/TrEMBL
      B2R9D8
      Conserved Domains (7) summary
      PHA02693
      Location:54127
      PHA02693; hypothetical protein; Provisional
      smart00349
      Location:1576
      KRAB; krueppel associated box
      COG5048
      Location:229686
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:454474
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:592614
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:1552
      KRAB; KRAB box
      pfam13465
      Location:360384
      zf-H2C2_2; Zinc-finger double domain
    5. XM_011517293.3XP_011515595.1  zinc finger protein 7 isoform X1

      See identical proteins and their annotated locations for XP_011515595.1

      UniProtKB/Swiss-Prot
      B4DT08, D3DWN6, P17015, P17097, Q8N8Y4
      UniProtKB/TrEMBL
      B2R9D8
      Related
      ENSP00000432724.1, ENST00000528372.5
      Conserved Domains (7) summary
      PHA02693
      Location:43116
      PHA02693; hypothetical protein; Provisional
      smart00349
      Location:465
      KRAB; krueppel associated box
      COG5048
      Location:218675
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:443463
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:581603
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:441
      KRAB; KRAB box
      pfam13465
      Location:349373
      zf-H2C2_2; Zinc-finger double domain
    6. XM_011517296.4XP_011515598.1  zinc finger protein 7 isoform X2

      See identical proteins and their annotated locations for XP_011515598.1

      UniProtKB/TrEMBL
      B2R9D8, E9PJX9
      Conserved Domains (4) summary
      smart00349
      Location:464
      KRAB; krueppel associated box
      COG5048
      Location:217674
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:442462
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl28640
      Location:46115
      PHA02693; hypothetical protein; Provisional
    7. XM_047422204.1XP_047278160.1  zinc finger protein 7 isoform X3

    8. XM_006716654.4XP_006716717.1  zinc finger protein 7 isoform X6

      See identical proteins and their annotated locations for XP_006716717.1

      UniProtKB/TrEMBL
      F5H290, Q59F42
      Conserved Domains (2) summary
      COG5048
      Location:122543
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:347367
      ZF_C2H2; C2H2 Zn finger [structural motif]
    9. XM_047422205.1XP_047278161.1  zinc finger protein 7 isoform X4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      146001303..146021302
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054361194.1XP_054217169.1  zinc finger protein 7 isoform X8

    2. XM_054361189.1XP_054217164.1  zinc finger protein 7 isoform X3

    3. XM_054361192.1XP_054217167.1  zinc finger protein 7 isoform X6

      UniProtKB/TrEMBL
      B4DWJ4
    4. XM_054361186.1XP_054217161.1  zinc finger protein 7 isoform X1

    5. XM_054361193.1XP_054217168.1  zinc finger protein 7 isoform X7

    6. XM_054361187.1XP_054217162.1  zinc finger protein 7 isoform X1

    7. XM_054361188.1XP_054217163.1  zinc finger protein 7 isoform X2

    8. XM_054361191.1XP_054217166.1  zinc finger protein 7 isoform X5

    9. XM_054361190.1XP_054217165.1  zinc finger protein 7 isoform X4