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    ZNF2 zinc finger protein 2 [ Homo sapiens (human) ]

    Gene ID: 7549, updated on 5-Mar-2024

    Summary

    Official Symbol
    ZNF2provided by HGNC
    Official Full Name
    zinc finger protein 2provided by HGNC
    Primary source
    HGNC:HGNC:12991
    See related
    Ensembl:ENSG00000275111 MIM:194500; AllianceGenome:HGNC:12991
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    A1-5; ZNF661; Zfp661
    Summary
    The protein encoded by this gene belongs to the C2H2-type zinc-finger protein family. The exact function of this gene is not known, however, zinc-finger proteins are known to interact with DNA and function as transcription regulators. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2014]
    Expression
    Ubiquitous expression in testis (RPKM 1.8), thyroid (RPKM 1.6) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See ZNF2 in Genome Data Viewer
    Location:
    2q11.1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (95165809..95184317)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (95672291..95690797)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (95831554..95850065)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene NANOG hESC enhancer GRCh37_chr2:95753198-95753763 Neighboring gene mitochondrial ribosomal protein S5 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11739 Neighboring gene zinc finger protein 514 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11740 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:95830542-95831178 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:95831179-95831813 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:95843643-95844143 Neighboring gene zinc finger protein 2-like Neighboring gene solute carrier family 2 pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables zinc ion binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    zinc finger protein 2
    Names
    zinc finger protein 2.2
    zinc finger protein 661

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_033798.1 RefSeqGene

      Range
      5393..23901
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001017396.3NP_001017396.1  zinc finger protein 2 isoform b

      See identical proteins and their annotated locations for NP_001017396.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the 5' region and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus than isoform a.
      Source sequence(s)
      AC092835, AI631860, AK295739, AV726545, X60152
      Consensus CDS
      CCDS42713.1
      UniProtKB/Swiss-Prot
      Q9BSG1
      UniProtKB/TrEMBL
      B0AZN8
      Related
      ENSP00000480057.1, ENST00000617923.4
      Conserved Domains (5) summary
      smart00349
      Location:132
      KRAB; krueppel associated box
      COG5048
      Location:144370
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:189209
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:299321
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:145170
      zf-H2C2_2; Zinc-finger double domain
    2. NM_001282398.2NP_001269327.1  zinc finger protein 2 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (c) is shorter than isoform a.
      Source sequence(s)
      AC092835, AI631860, AK295739, AV726545, X60152
      Consensus CDS
      CCDS62957.1
      UniProtKB/Swiss-Prot
      Q9BSG1
      UniProtKB/TrEMBL
      A0A087X063
      Related
      ENSP00000483131.1, ENST00000622059.4
      Conserved Domains (6) summary
      smart00349
      Location:1460
      KRAB; krueppel associated box
      COG5048
      Location:148374
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:193213
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:136157
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:1453
      KRAB; KRAB box
      pfam13465
      Location:149174
      zf-H2C2_2; Zinc-finger double domain
    3. NM_001291604.2NP_001278533.1  zinc finger protein 2 isoform d

      See identical proteins and their annotated locations for NP_001278533.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks two alternate exons in the 5' region and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (d) is shorter than isoform a.
      Source sequence(s)
      AC092835, AI631860, CR749650
      Consensus CDS
      CCDS77435.1
      UniProtKB/TrEMBL
      Q68CY6
      Related
      ENSP00000477960.1, ENST00000611463.1
      Conserved Domains (3) summary
      COG5048
      Location:106332
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:151171
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:107132
      zf-H2C2_2; Zinc-finger double domain
    4. NM_001291605.2NP_001278534.1  zinc finger protein 2 isoform e

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (e) is longer than isoform a.
      Source sequence(s)
      AC092835, AI631860, AK299058, DA497792, KF459620
      Consensus CDS
      CCDS77434.1
      UniProtKB/TrEMBL
      A0A087WYR5
      Related
      ENSP00000482030.1, ENST00000611147.1
      Conserved Domains (6) summary
      smart00349
      Location:1474
      KRAB; krueppel associated box
      COG5048
      Location:199425
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:244264
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:187208
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:1453
      KRAB; KRAB box
      pfam13465
      Location:200225
      zf-H2C2_2; Zinc-finger double domain
    5. NM_021088.4NP_066574.2  zinc finger protein 2 isoform a

      See identical proteins and their annotated locations for NP_066574.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform a.
      Source sequence(s)
      AC092835, AI631860, AK295739, AV726545, BC005068
      Consensus CDS
      CCDS42712.1
      UniProtKB/Swiss-Prot
      A8MWV7, B0AZN8, B4DIR4, Q4ZFY6, Q96G44, Q9BSG1, Q9UMC5
      Related
      ENSP00000480297.1, ENST00000614034.5
      Conserved Domains (4) summary
      smart00349
      Location:1474
      KRAB; krueppel associated box
      COG5048
      Location:186412
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:231251
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:174195
      zf-C2H2; Zinc finger, C2H2 type

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      95165809..95184317
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      95672291..95690797
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)