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    Secisbp2 SECIS binding protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 75420, updated on 12-Aug-2018

    Summary

    Official Symbol
    Secisbp2provided by MGI
    Official Full Name
    SECIS binding protein 2provided by MGI
    Primary source
    MGI:MGI:1922670
    See related
    Ensembl:ENSMUSG00000035139 Vega:OTTMUSG00000020967
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SBP2; 2210413N07Rik; 2810012K13Rik
    Summary
    The incorporation of selenocysteine into a protein requires the concerted action of an mRNA element called a sec insertion sequence (SECIS), a selenocysteine-specific translation elongation factor and a SECIS binding protein. With these elements in place, a UGA codon can be decoded as selenocysteine. The gene described in this record encodes a nuclear protein that functions as a SECIS binding protein. Mutations in a similar gene in human have been associated with a reduction in activity of a specific thyroxine deiodinase, a selenocysteine-containing enzyme, and abnormal thyroid hormone metabolism. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2015]
    Expression
    Ubiquitous expression in thymus adult (RPKM 8.0), spleen adult (RPKM 6.2) and 28 other tissues See more
    Orthologs

    Genomic context

    See Secisbp2 in Genome Data Viewer
    Location:
    13; 13 A5
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 13 NC_000079.6 (51650828..51684044)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (51747083..51779015)

    Chromosome 13 - NC_000079.6Genomic Context describing neighboring genes Neighboring gene src homology 2 domain-containing transforming protein C3 Neighboring gene CDC28 protein kinase regulatory subunit 2 Neighboring gene sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D Neighboring gene growth arrest and DNA-damage-inducible 45 gamma

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    General gene information

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    mRNA 3'-UTR binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mRNA 3'-UTR binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ribonucleoprotein complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ribonucleoprotein complex binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    selenocysteine insertion sequence binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    selenocysteine insertion sequence binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    selenocysteine insertion sequence binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neuron development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of selenocysteine incorporation ISO
    Inferred from Sequence Orthology
    more info
     
    selenocysteine incorporation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    selenocysteine incorporation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    striatum development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    mitochondrion HDA PubMed 
    ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ribonucleoprotein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    selenocysteine insertion sequence-binding protein 2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001308448.1NP_001295377.1  selenocysteine insertion sequence-binding protein 2 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 5' coding region compared to variant 1. This variant represents translation initiation at a downstream AUG compared to variant 1; the 5'-most initiation codon, as used in variant 1, is associated with a truncated ORF that would render the transcript a candidate for nonsense-mediated decay (NMD). Leaky scanning may allow translation initiation at the downstream AUG to encode an isoform (2) that has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC126547, AK012732, AK168634, BP760396, CA329104
      UniProtKB/TrEMBL
      Q3TGQ4
      Conserved Domains (1) summary
      pfam01248
      Location:598698
      Ribosomal_L7Ae; Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
    2. NM_029279.2NP_083555.1  selenocysteine insertion sequence-binding protein 2 isoform 1

      See identical proteins and their annotated locations for NP_083555.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC126547, AK168634, BP760396, CA329104
      Consensus CDS
      CCDS36665.1
      UniProtKB/TrEMBL
      Q3TGQ4, Q3U1C4
      Related
      ENSMUSP00000045740.8, OTTMUSP00000022992, ENSMUST00000040117.14, OTTMUST00000049571
      Conserved Domains (1) summary
      pfam01248
      Location:662762
      Ribosomal_L7Ae; Ribosomal protein L7Ae/L30e/S12e/Gadd45 family

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000079.6 Reference GRCm38.p4 C57BL/6J

      Range
      51650828..51684044
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006516964.3XP_006517027.1  selenocysteine insertion sequence-binding protein 2 isoform X1

    2. XM_006516965.3XP_006517028.1  selenocysteine insertion sequence-binding protein 2 isoform X2

    3. XM_006516966.1XP_006517029.1  selenocysteine insertion sequence-binding protein 2 isoform X3

      Conserved Domains (1) summary
      pfam01248
      Location:365465
      Ribosomal_L7Ae; Ribosomal protein L7Ae/L30e/S12e/Gadd45 family

    RNA

    1. XR_382238.3 RNA Sequence

    2. XR_382237.3 RNA Sequence

    3. XR_001780824.1 RNA Sequence

    4. XR_382236.3 RNA Sequence

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