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    Arhgap12 Rho GTPase activating protein 12 [ Mus musculus (house mouse) ]

    Gene ID: 75415, updated on 23-Jun-2021

    Summary

    Official Symbol
    Arhgap12provided by MGI
    Official Full Name
    Rho GTPase activating protein 12provided by MGI
    Primary source
    MGI:MGI:1922665
    See related
    Ensembl:ENSMUSG00000041225
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2810011M08Rik
    Expression
    Broad expression in bladder adult (RPKM 10.7), CNS E14 (RPKM 8.1) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Arhgap12 in Genome Data Viewer
    Location:
    18; 18 A1
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (6024448..6136102, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (6024448..6136098, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 18 NC_000084.5 (6024446..6136096, complement)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 34804 Neighboring gene predicted gene, 41663 Neighboring gene predicted gene, 41662 Neighboring gene phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoribosylaminoimidazole, succinocarboxamide synthetase pseudogene Neighboring gene predicted gene, 18278 Neighboring gene kinesin family member 5B Neighboring gene predicted gene, 41664 Neighboring gene ribosomal protein L27, pseudogene 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    involved_in actin filament organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in morphogenesis of an epithelial sheet ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of small GTPase mediated signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phagocytosis, engulfment ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in phagocytic cup ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    rho GTPase-activating protein 12
    Names
    rho-type GTPase-activating protein 12

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039692.1NP_001034781.1  rho GTPase-activating protein 12 isoform 1

      See identical proteins and their annotated locations for NP_001034781.1

      Status: VALIDATED

      Source sequence(s)
      AC168050, AK031648, AK077063, BC037608
      Consensus CDS
      CCDS37723.1
      UniProtKB/Swiss-Prot
      Q8C0D4
      Related
      ENSMUSP00000138585.2, ENSMUST00000182559.8
      Conserved Domains (6) summary
      cd12070
      Location:1372
      SH3_ARHGAP12; Src Homology 3 domain of Rho GTPase-activating protein 12
      cd00201
      Location:266296
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd04403
      Location:646831
      RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...
      cd13233
      Location:457568
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
      pfam00169
      Location:467566
      PH; PH domain
      pfam16618
      Location:69264
      SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12
    2. NM_029277.2NP_083553.2  rho GTPase-activating protein 12 isoform 2

      See identical proteins and their annotated locations for NP_083553.2

      Status: VALIDATED

      Source sequence(s)
      AC168050, AK077063, BC037608
      Consensus CDS
      CCDS37722.1
      UniProtKB/Swiss-Prot
      Q8C0D4
      UniProtKB/TrEMBL
      B2RUJ8
      Related
      ENSMUSP00000076376.6, ENSMUST00000077128.13
      Conserved Domains (6) summary
      cd12070
      Location:1372
      SH3_ARHGAP12; Src Homology 3 domain of Rho GTPase-activating protein 12
      cd00201
      Location:266296
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd04403
      Location:621806
      RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...
      cd13233
      Location:432543
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
      pfam00169
      Location:442541
      PH; PH domain
      pfam16618
      Location:69264
      SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      6024448..6136102 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030250623.2XP_030106483.1  rho GTPase-activating protein 12 isoform X8

      Conserved Domains (4) summary
      cd12070
      Location:1372
      SH3_ARHGAP12; Src Homology 3 domain of Rho GTPase-activating protein 12
      cd04403
      Location:487672
      RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
      cd13233
      Location:298409
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
      pfam16618
      Location:69226
      SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12
    2. XM_036161302.1XP_036017195.1  rho GTPase-activating protein 12 isoform X7

      Conserved Domains (4) summary
      cd12070
      Location:1372
      SH3_ARHGAP12; Src Homology 3 domain of Rho GTPase-activating protein 12
      cd04403
      Location:512697
      RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
      cd13233
      Location:323434
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
      pfam16618
      Location:69226
      SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12
    3. XM_017318001.2XP_017173490.1  rho GTPase-activating protein 12 isoform X6

      Conserved Domains (4) summary
      cd12070
      Location:1372
      SH3_ARHGAP12; Src Homology 3 domain of Rho GTPase-activating protein 12
      cd04403
      Location:517702
      RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
      cd13233
      Location:328439
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
      pfam16618
      Location:69226
      SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12
    4. XM_006526316.2XP_006526379.1  rho GTPase-activating protein 12 isoform X5

      UniProtKB/TrEMBL
      S4R203
      Related
      ENSMUSP00000138444.2, ENSMUST00000182383.8
      Conserved Domains (6) summary
      cd12070
      Location:1372
      SH3_ARHGAP12; Src Homology 3 domain of Rho GTPase-activating protein 12
      COG5104
      Location:257362
      PRP40; Splicing factor [RNA processing and modification]
      cd00201
      Location:266296
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd04403
      Location:574759
      RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
      cd13233
      Location:385496
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
      pfam16618
      Location:69264
      SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12
    5. XM_036161301.1XP_036017194.1  rho GTPase-activating protein 12 isoform X4

      Related
      ENSMUSP00000138496.2, ENSMUST00000182066.8
      Conserved Domains (6) summary
      cd12070
      Location:1372
      SH3_ARHGAP12; Src Homology 3 domain of Rho GTPase-activating protein 12
      COG5104
      Location:257362
      PRP40; Splicing factor [RNA processing and modification]
      cd00201
      Location:266296
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd04403
      Location:599784
      RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
      cd13233
      Location:410521
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
      pfam16618
      Location:69264
      SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12
    6. XM_006526315.2XP_006526378.1  rho GTPase-activating protein 12 isoform X3

      UniProtKB/TrEMBL
      A0A0A0MQ95
      Related
      ENSMUSP00000054209.8, ENSMUST00000062584.14
      Conserved Domains (6) summary
      cd12070
      Location:1372
      SH3_ARHGAP12; Src Homology 3 domain of Rho GTPase-activating protein 12
      COG5104
      Location:257362
      PRP40; Splicing factor [RNA processing and modification]
      cd00201
      Location:266296
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd04403
      Location:604789
      RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
      cd13233
      Location:415526
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
      pfam16618
      Location:69264
      SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12
    7. XM_011247018.2XP_011245320.1  rho GTPase-activating protein 12 isoform X2

      Conserved Domains (6) summary
      cd12070
      Location:1372
      SH3_ARHGAP12; Src Homology 3 domain of Rho GTPase-activating protein 12
      COG5104
      Location:257409
      PRP40; Splicing factor [RNA processing and modification]
      cd00201
      Location:266296
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd04403
      Location:626811
      RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
      cd13233
      Location:437548
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
      pfam16618
      Location:69264
      SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12
    8. XM_006526314.2XP_006526377.1  rho GTPase-activating protein 12 isoform X1

      UniProtKB/TrEMBL
      S4R221
      Related
      ENSMUSP00000138464.2, ENSMUST00000182213.8
      Conserved Domains (6) summary
      cd12070
      Location:1372
      SH3_ARHGAP12; Src Homology 3 domain of Rho GTPase-activating protein 12
      COG5104
      Location:257409
      PRP40; Splicing factor [RNA processing and modification]
      cd00201
      Location:266296
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd04403
      Location:651836
      RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
      cd13233
      Location:462573
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
      pfam16618
      Location:69264
      SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12
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